Click here to switch to the map view.

The map label for this gene is nadB1 [H]

Identifier: 78067305

GI number: 78067305

Start: 2948596

End: 2950182

Strand: Direct

Name: nadB1 [H]

Synonym: Bcep18194_A5836

Alternate gene names: 78067305

Gene position: 2948596-2950182 (Clockwise)

Preceding gene: 78067304

Following gene: 78067312

Centisome position: 79.82

GC content: 67.74

Gene sequence:

>1587_bases
ATGAAATTCGACGTGGCGATCGTCGGCAGCGGCCTGGCAGGGCTGTCGGTCGCACTCAACCTGGCCAGCACGCGACGTGT
CGCGCTGATCGCGAAACGGTCGATGATGGAGGGCGCGAGCGATAACGCGCAAGGCGGCATCGCGGCTGTCCTCGATTCGG
CGGACAGCATCGAGAACCACGTCGACGACACGCTGGTCGCCGGTGGCGGCTTGTGCGACGAAGGCGCGACGCGCTATATC
GTCGAGCACGGCCGCGAAGCGATCGAATGGCTGATCTCGCAGGGCGTGCCGTTCACGAAGGACGACGCGGCCGAACTCGG
CTTCCACCTCACGCGCGAAGGCGGCCACAGCCACCGCCGGATCATCCATGCGGCCGATGCGACCGGCCATGCGGTGCTCG
CCACGCTGTCGGCGCGTGCGCGCCAGCATCCGAACATCACGTTCTTCGAAAACCACCACGCGATCGACCTGATCACGTCG
GACCGGCTCGGCCTGCCCGGCCGCCGCTGTCACGGCCTGTACGCGCTCGACGTCGACAACGATCGCACGATCACGATCGA
GGCGCCGCATACGGTGCTCGCAACGGGCGGCGCCGGCAAGGTGTACCTGTACACGACGAACCCCGACACCGCGACCGGCG
ACGGCATCGCGATGGCGTGGCGTGCGGGCTGCCGCGTGTCGAACATGGAGTTCATCCAGTTCCACCCGACCTGCCTGTTC
CATCCGTATGCGAAGTCGTTCCTGATTTCCGAAGCCGTACGCGGCGAAGGCGGCCTGTTGAAGCTGCCCGACGGCACGCG
CTTCATGCCCGCGCACGATCCGCGAGCCGAACTCGCGCCGCGCGACATCGTCGCGCGCGCGATCGACTTCGAGATCAAGA
AGCGCGGGATCGACTGCGTGTATCTCGACATCAGCCACCAGCCGGAAGCGTTCCTGCGCGAACACTTCCCGACGATCCAC
GCGCGCTGCCTCGAATTCGGCATCGACATCGCGAAAGAGCCGATTCCCGTCGTGCCGGCCGCGCACTACACGTGCGGCGG
CGTCGTCACCGACCTCGCCGGGCGCACCGATCTCGCGGGCCTGTATGCGGTCGGCGAAACGTCGTACACGGGGCTCCACG
GCGCGAACCGGCTCGCGAGCAACTCGCTGCTCGAATGTCTGGTGATCGGCCGCGCGGCGGCCGAGGCGATCGAGGCATCC
GGCTTCGATGCCGAAACGCCGGCCACGCTGCCCGCGTGGGACGAAAGCCGCGTGTCGGATGCGGACGAGGAAGTCGTCGT
CGCGCACAACTGGGACGAGCTGCGCCGCCTGATGTGGAACTACGTCGGCATCGTGCGCACCGACAAGCGCCTCGAACGCG
CGAAGCACCGGCTGTCGCTGCTGCGCGACGAGATCCACGAGTACTACGCGAACTTCCGCGTGACGCGCGACCTGCTCGAG
CTGCGCAACCTCGTCGACGTGGCAACGCTGATCGTGAAGAGCGCACACTCGCGCCGCGAAAGCCGCGGGCTGCACTACAG
CCGCGACTGGCCGAACTCGCTGCCGAAAGCGCTGCCGAGCGTGCTCACGCCGCGCGCGCGCCGCTGA

Upstream 100 bases:

>100_bases
TTTGCGCGCACGCTCCGGCGCGACGCGGTATGCTCTCCCCTTTCCGCGGCCACGGCCGCCGGAACGCACAAGATCAAAAG
CGTAACGATGGAGATGCAGC

Downstream 100 bases:

>100_bases
CCGGCACGCCCTTCCTGGCTGCGGCCGCACAAGAAAAAAGCCGTTGGCGTTTGCGCGCCAACGGCTTTTTTGTCTGATCG
ACGGCGTTCGGTCAGTCGAC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MKFDVAIVGSGLAGLSVALNLASTRRVALIAKRSMMEGASDNAQGGIAAVLDSADSIENHVDDTLVAGGGLCDEGATRYI
VEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIHAADATGHAVLATLSARARQHPNITFFENHHAIDLITS
DRLGLPGRRCHGLYALDVDNDRTITIEAPHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVSNMEFIQFHPTCLF
HPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAPRDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIH
ARCLEFGIDIAKEPIPVVPAAHYTCGGVVTDLAGRTDLAGLYAVGETSYTGLHGANRLASNSLLECLVIGRAAAEAIEAS
GFDAETPATLPAWDESRVSDADEEVVVAHNWDELRRLMWNYVGIVRTDKRLERAKHRLSLLRDEIHEYYANFRVTRDLLE
LRNLVDVATLIVKSAHSRRESRGLHYSRDWPNSLPKALPSVLTPRARR

Sequences:

>Translated_528_residues
MKFDVAIVGSGLAGLSVALNLASTRRVALIAKRSMMEGASDNAQGGIAAVLDSADSIENHVDDTLVAGGGLCDEGATRYI
VEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIHAADATGHAVLATLSARARQHPNITFFENHHAIDLITS
DRLGLPGRRCHGLYALDVDNDRTITIEAPHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVSNMEFIQFHPTCLF
HPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAPRDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIH
ARCLEFGIDIAKEPIPVVPAAHYTCGGVVTDLAGRTDLAGLYAVGETSYTGLHGANRLASNSLLECLVIGRAAAEAIEAS
GFDAETPATLPAWDESRVSDADEEVVVAHNWDELRRLMWNYVGIVRTDKRLERAKHRLSLLRDEIHEYYANFRVTRDLLE
LRNLVDVATLIVKSAHSRRESRGLHYSRDWPNSLPKALPSVLTPRARR
>Mature_528_residues
MKFDVAIVGSGLAGLSVALNLASTRRVALIAKRSMMEGASDNAQGGIAAVLDSADSIENHVDDTLVAGGGLCDEGATRYI
VEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRRIIHAADATGHAVLATLSARARQHPNITFFENHHAIDLITS
DRLGLPGRRCHGLYALDVDNDRTITIEAPHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVSNMEFIQFHPTCLF
HPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAPRDIVARAIDFEIKKRGIDCVYLDISHQPEAFLREHFPTIH
ARCLEFGIDIAKEPIPVVPAAHYTCGGVVTDLAGRTDLAGLYAVGETSYTGLHGANRLASNSLLECLVIGRAAAEAIEAS
GFDAETPATLPAWDESRVSDADEEVVVAHNWDELRRLMWNYVGIVRTDKRLERAKHRLSLLRDEIHEYYANFRVTRDLLE
LRNLVDVATLIVKSAHSRRESRGLHYSRDWPNSLPKALPSVLTPRARR

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=506, Percent_Identity=34.7826086956522, Blast_Score=243, Evalue=3e-64,
Organism=Escherichia coli, GI1788928, Length=524, Percent_Identity=59.9236641221374, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=524, Percent_Identity=36.6412213740458, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI1786942, Length=552, Percent_Identity=33.695652173913, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=528, Percent_Identity=33.9015151515151, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17505833, Length=529, Percent_Identity=32.8922495274102, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71986328, Length=477, Percent_Identity=27.8825995807128, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322701, Length=531, Percent_Identity=32.9566854990584, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322416, Length=514, Percent_Identity=33.6575875486381, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322511, Length=480, Percent_Identity=27.9166666666667, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320788, Length=476, Percent_Identity=28.1512605042017, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137288, Length=533, Percent_Identity=33.3958724202627, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24655642, Length=533, Percent_Identity=33.3958724202627, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24655647, Length=533, Percent_Identity=33.3958724202627, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24663005, Length=550, Percent_Identity=32.7272727272727, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 57836; Mature: 57836

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDVAIVGSGLAGLSVALNLASTRRVALIAKRSMMEGASDNAQGGIAAVLDSADSIENH
CEEEEEEECCCCCHHHHHEEHHCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHH
VDDTLVAGGGLCDEGATRYIVEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRR
HCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCEEEECCCCCCCEE
IIHAADATGHAVLATLSARARQHPNITFFENHHAIDLITSDRLGLPGRRCHGLYALDVDN
EEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCHHCEEEEEECCC
DRTITIEAPHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVSNMEFIQFHPTCLF
CCEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEE
HPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAPRDIVARAIDFEIKKRGIDCV
CHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEE
YLDISHQPEAFLREHFPTIHARCLEFGIDIAKEPIPVVPAAHYTCGGVVTDLAGRTDLAG
EEECCCCCHHHHHHHCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCE
LYAVGETSYTGLHGANRLASNSLLECLVIGRAAAEAIEASGFDAETPATLPAWDESRVSD
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
ADEEVVVAHNWDELRRLMWNYVGIVRTDKRLERAKHRLSLLRDEIHEYYANFRVTRDLLE
CCCCEEEEECHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRNLVDVATLIVKSAHSRRESRGLHYSRDWPNSLPKALPSVLTPRARR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKFDVAIVGSGLAGLSVALNLASTRRVALIAKRSMMEGASDNAQGGIAAVLDSADSIENH
CEEEEEEECCCCCHHHHHEEHHCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHH
VDDTLVAGGGLCDEGATRYIVEHGREAIEWLISQGVPFTKDDAAELGFHLTREGGHSHRR
HCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCEEEECCCCCCCEE
IIHAADATGHAVLATLSARARQHPNITFFENHHAIDLITSDRLGLPGRRCHGLYALDVDN
EEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCHHCEEEEEECCC
DRTITIEAPHTVLATGGAGKVYLYTTNPDTATGDGIAMAWRAGCRVSNMEFIQFHPTCLF
CCEEEEECCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEE
HPYAKSFLISEAVRGEGGLLKLPDGTRFMPAHDPRAELAPRDIVARAIDFEIKKRGIDCV
CHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEE
YLDISHQPEAFLREHFPTIHARCLEFGIDIAKEPIPVVPAAHYTCGGVVTDLAGRTDLAG
EEECCCCCHHHHHHHCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCE
LYAVGETSYTGLHGANRLASNSLLECLVIGRAAAEAIEASGFDAETPATLPAWDESRVSD
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
ADEEVVVAHNWDELRRLMWNYVGIVRTDKRLERAKHRLSLLRDEIHEYYANFRVTRDLLE
CCCCEEEEECHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRNLVDVATLIVKSAHSRRESRGLHYSRDWPNSLPKALPSVLTPRARR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]