Click here to switch to the map view.

The map label for this gene is ilvR [H]

Identifier: 78067261

GI number: 78067261

Start: 2905914

End: 2906828

Strand: Reverse

Name: ilvR [H]

Synonym: Bcep18194_A5792

Alternate gene names: 78067261

Gene position: 2906828-2905914 (Counterclockwise)

Preceding gene: 78067264

Following gene: 78067260

Centisome position: 78.69

GC content: 71.48

Gene sequence:

>915_bases
ATGGCCGATCCGACTCCCGACCTGCGCCAGTGGCGCTATTTCGTGACCGTCGCCGACGAGCGACATTTCGGCCGCGCGGC
CGAACGCCTGTCGATGACACAGCCGCCGCTGTCACAGGCGATCCGTGCGCTGGAGGATGCGCTTGGCGTCGCGCTGTTCG
CGCGCACCAAGCGCTCGGTCGCGCTGACTGCGGTCGGCGCGGCGCTGCTGCCCGACGTGCGCCGGCTGCTTGCATCGGCC
GATGCGCTGCCGCCGCTCGCGCGACGGCTTGCGCGCGGCGAGGCCGGCTCGCTGTCGCTCGCGTTCGTGTCGACCGCCGA
TTACGGGCTGCTGCCTGCGCTGCTGCGTGCGTTCGGCACGCGCTATCCGCAGGTGCGGCTGCAACTCGCGGAGGCGACGA
GCGACGTGCAGATCGACGAACTCGTCGCGGGCCGCATCGACGCGGGGCTCGTCATTCCGCCCGTGCCGCCGCGCCACGCG
GCCGGGCTGTCGTACCTGCCCGTCGTGCGCGAGCCGCTGGTGGTCGCGATGCCGGCGGCGGCGAGCGACGCGCCTGAAGA
CGAGCCCGTGCATCTCGCCGAGGTTGCCGCGTTACCGCTCGTGATCTTTCCGCGTCGTTTGGCGCCCGGCTTTTATGACA
TCATTACGGGCTGCTACGGCGCGGCGGGGGAAACTCCGCACATCGGCCAGGAGGCGATCCAGATGCAGACGATCGTCAGC
CTCGTGTCGGCCGGCATGGGCGTCGCACTGGTGCCGCAATCGCTGCGTAACCTGCGGCGCACCGGCGTGGTCTACCGGCC
GCTTGCCGATCACGCGCCGGTCGTCGAGACAGGCCTCGTGTGGCGCACCGGCGACGTGAGCCCCGTGCTGGCCGGCTTCA
TCGACGTCGTGCGCGCGCAGGGCCTCGCCACGTGA

Upstream 100 bases:

>100_bases
ACGGCGTGCAGGTTCGGATCAATCAAGAATGGAGTTTCCGGATTGGGATGTCCAATATATTATTTGTCGCGTATTAAGTC
GTTTACTGAATGAAAAAGGC

Downstream 100 bases:

>100_bases
CGTGAACGATGACGCACCGGTGCCGTCCAACGCGCGGTGCTGCGCGTTTGCGACGGCCGTACCGCATTCGAAAACTTCTT
CGCTAACCCATGATCATTCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVALTAVGAALLPDVRRLLASA
DALPPLARRLARGEAGSLSLAFVSTADYGLLPALLRAFGTRYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHA
AGLSYLPVVREPLVVAMPAAASDAPEDEPVHLAEVAALPLVIFPRRLAPGFYDIITGCYGAAGETPHIGQEAIQMQTIVS
LVSAGMGVALVPQSLRNLRRTGVVYRPLADHAPVVETGLVWRTGDVSPVLAGFIDVVRAQGLAT

Sequences:

>Translated_304_residues
MADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVALTAVGAALLPDVRRLLASA
DALPPLARRLARGEAGSLSLAFVSTADYGLLPALLRAFGTRYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHA
AGLSYLPVVREPLVVAMPAAASDAPEDEPVHLAEVAALPLVIFPRRLAPGFYDIITGCYGAAGETPHIGQEAIQMQTIVS
LVSAGMGVALVPQSLRNLRRTGVVYRPLADHAPVVETGLVWRTGDVSPVLAGFIDVVRAQGLAT
>Mature_303_residues
ADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSVALTAVGAALLPDVRRLLASAD
ALPPLARRLARGEAGSLSLAFVSTADYGLLPALLRAFGTRYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHAA
GLSYLPVVREPLVVAMPAAASDAPEDEPVHLAEVAALPLVIFPRRLAPGFYDIITGCYGAAGETPHIGQEAIQMQTIVSL
VSAGMGVALVPQSLRNLRRTGVVYRPLADHAPVVETGLVWRTGDVSPVLAGFIDVVRAQGLAT

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=291, Percent_Identity=40.5498281786942, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=34.4594594594595, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI2367136, Length=299, Percent_Identity=33.4448160535117, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1790399, Length=288, Percent_Identity=30.5555555555556, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI145693105, Length=248, Percent_Identity=27.0161290322581, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=27.1186440677966, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788748, Length=302, Percent_Identity=29.1390728476821, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI157672245, Length=244, Percent_Identity=30.327868852459, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=37.2262773722628, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=28.9156626506024, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=26.0869565217391, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87081904, Length=206, Percent_Identity=32.0388349514563, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790208, Length=262, Percent_Identity=29.0076335877863, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=141, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082132, Length=303, Percent_Identity=26.4026402640264, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI48994962, Length=71, Percent_Identity=46.4788732394366, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789173, Length=145, Percent_Identity=34.4827586206897, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786713, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788296, Length=228, Percent_Identity=28.5087719298246, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32302; Mature: 32171

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSV
CCCCCCCHHHEEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
ALTAVGAALLPDVRRLLASADALPPLARRLARGEAGSLSLAFVSTADYGLLPALLRAFGT
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCC
RYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHAAGLSYLPVVREPLVVAMPAA
CCCHHEEEHHHCCCCCCHHHHHHHHCCCCEEECCCCCCHHCCCCCHHHHHCCEEEEECCC
ASDAPEDEPVHLAEVAALPLVIFPRRLAPGFYDIITGCYGAAGETPHIGQEAIQMQTIVS
CCCCCCCCCCHHHHHHHHHHHEEHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LVSAGMGVALVPQSLRNLRRTGVVYRPLADHAPVVETGLVWRTGDVSPVLAGFIDVVRAQ
HHHCCCCCEEHHHHHHHHHHCCEEEECCCCCCCCHHCCCEEECCCCHHHHHHHHHHHHHH
GLAT
CCCC
>Mature Secondary Structure 
ADPTPDLRQWRYFVTVADERHFGRAAERLSMTQPPLSQAIRALEDALGVALFARTKRSV
CCCCCCHHHEEEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
ALTAVGAALLPDVRRLLASADALPPLARRLARGEAGSLSLAFVSTADYGLLPALLRAFGT
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCC
RYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHAAGLSYLPVVREPLVVAMPAA
CCCHHEEEHHHCCCCCCHHHHHHHHCCCCEEECCCCCCHHCCCCCHHHHHCCEEEEECCC
ASDAPEDEPVHLAEVAALPLVIFPRRLAPGFYDIITGCYGAAGETPHIGQEAIQMQTIVS
CCCCCCCCCCHHHHHHHHHHHEEHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LVSAGMGVALVPQSLRNLRRTGVVYRPLADHAPVVETGLVWRTGDVSPVLAGFIDVVRAQ
HHHCCCCCEEHHHHHHHHHHCCEEEECCCCCCCCHHCCCEEECCCCHHHHHHHHHHHHHH
GLAT
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]