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The map label for this gene is envZ [H]

Identifier: 78067196

GI number: 78067196

Start: 2832733

End: 2834049

Strand: Reverse

Name: envZ [H]

Synonym: Bcep18194_A5727

Alternate gene names: 78067196

Gene position: 2834049-2832733 (Counterclockwise)

Preceding gene: 78067197

Following gene: 78067194

Centisome position: 76.72

GC content: 71.6

Gene sequence:

>1317_bases
ATGCGCAAACCCATTGATTCGCTGTTCGGGCGGCTGGCGCTACTCGTCGTCGGTGTCCTGCTCCTGTCGCACTTCGCGTG
GTTTTTCGCGATGCGGCTCGAGCGCAGCCAGATGCAGACGCGTTACGCGGTCGAAGAGGCCGCGTTCCTGGTCGACGCGG
TGCGCCAGCACGTCGAGCGCACGCCCGACCAGCCGTTGCCGTCGCGCGTGCGGCTCGTGACGCCCGACAGCACCGACGTA
CCGAATGGCGATCCGTCGAACCTGCCGGCGCCGCTCAAGCGGTTCCGCGACGACGTGAGCGAGCGGATGCCGCCCGGCAC
GCGCGTCGAGATCGGCGCGCCCGGCCATCCGCCGGTGCTGTGGGTGAAGGAGCCGACCGACCGCAACTGGATCGTGGTGC
CGGTGCAGCCGCTGCGGCCGCCGCGCTCGCTCGACCGGATGCTGCTGTGGCTCGGCACGATCTTCTCGGCCGGCGTGATC
GCCGCGCTGTTCGCGGCCTGGCAACTGCAGCAGCCGCTGCGCTCGCTGGCACGTGCGGTCGCGCGCTTCGGCCGCGGCCA
GCCGGTGCCGCCGCTGCGCGAGCGCGGCCCGCGCGAGCTGCGCCAGCTCACGCATGGCTTCAACCAGATGGTGGAACAGG
TGTCGCAGGCCGAGAGCGACCGCGCGGTGATGCTCGCGGGCGTGGCGCACGATTTGCGCACGCCGCTTGCGCGGATGCGG
CTGCGGGCGGAGATGATGGACGACGTCCGGTTGCGCGACGGCGTCGTGCGCGATGTCGATTCGATGTCGCACATCGTCGA
TCAATTCCTGGTGTTTGCGCACGGCGGGTCCGATCGCAGCGAGCCGGTGCCGGTCGATCAGGCGTGCGAGCGGATCGCGC
GCAGCTATCGCGCGGTCGCGCCGAACGCGCCGACGGTCCAGACCCGGCTCGACGCCGATCCGGGTTTCCGGCTGCCGACG
GCGACGCTCGACCGGATCCTGTCGAACCTGCTCGACAATGCGCATGCATACGGTGCGCCGCCCGTGCTCGTCGAGACGGC
GCGCACGCCGACCGGCTACGTGCTGTCGGTCAGCGACAGCGGCGGCGGGATCGCGCCGCGCGATCTCGCGGCGGCCACGC
GGCCGTTCGTACGGCTCGACCCCGCGCGCGGCGGGAACGGCCACAGCGGGCTCGGGCTCGCGATCGTCGAGCGGCTGGTG
CTCAGGCTGGGCGGGGCGTGCGACATCGGCAACCGCCCCGAAGGTGGCCTGCGCGTGTCGATGACGTTCCCGTTCGAGGT
CGTGCCGAAGGACGAACCCCACGCACAGGCCGCATAA

Upstream 100 bases:

>100_bases
TGGCGCCTGCGCCGCATCCTCGAAACGGATCCGTCGACGCCACGCTTCATCCAGACGGTCCGTGGGCGCGGCTATGTGTT
CGTGCCCGACGGCGAGGCCC

Downstream 100 bases:

>100_bases
GCGGCTGCGGCGCCGGCCCGGCCGGGCTGGCGCCGCGTGGCATCATTCGAACAGCGTGCCGAGCGTCTCGGCCGCGTTGC
TGTCGATGGTGTTGTAGGTC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERSQMQTRYAVEEAAFLVDAVRQHVERTPDQPLPSRVRLVTPDSTDV
PNGDPSNLPAPLKRFRDDVSERMPPGTRVEIGAPGHPPVLWVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
LRAEMMDDVRLRDGVVRDVDSMSHIVDQFLVFAHGGSDRSEPVPVDQACERIARSYRAVAPNAPTVQTRLDADPGFRLPT
ATLDRILSNLLDNAHAYGAPPVLVETARTPTGYVLSVSDSGGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGACDIGNRPEGGLRVSMTFPFEVVPKDEPHAQAA

Sequences:

>Translated_438_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERSQMQTRYAVEEAAFLVDAVRQHVERTPDQPLPSRVRLVTPDSTDV
PNGDPSNLPAPLKRFRDDVSERMPPGTRVEIGAPGHPPVLWVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
LRAEMMDDVRLRDGVVRDVDSMSHIVDQFLVFAHGGSDRSEPVPVDQACERIARSYRAVAPNAPTVQTRLDADPGFRLPT
ATLDRILSNLLDNAHAYGAPPVLVETARTPTGYVLSVSDSGGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGACDIGNRPEGGLRVSMTFPFEVVPKDEPHAQAA
>Mature_438_residues
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERSQMQTRYAVEEAAFLVDAVRQHVERTPDQPLPSRVRLVTPDSTDV
PNGDPSNLPAPLKRFRDDVSERMPPGTRVEIGAPGHPPVLWVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVI
AALFAAWQLQQPLRSLARAVARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
LRAEMMDDVRLRDGVVRDVDSMSHIVDQFLVFAHGGSDRSEPVPVDQACERIARSYRAVAPNAPTVQTRLDADPGFRLPT
ATLDRILSNLLDNAHAYGAPPVLVETARTPTGYVLSVSDSGGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLV
LRLGGACDIGNRPEGGLRVSMTFPFEVVPKDEPHAQAA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=334, Percent_Identity=32.6347305389222, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1787894, Length=263, Percent_Identity=30.4182509505703, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=27.6978417266187, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=30.5785123966942, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=326, Percent_Identity=25.7668711656442, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=295, Percent_Identity=26.7796610169492, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082128, Length=270, Percent_Identity=25.1851851851852, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48138; Mature: 48138

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERSQMQTRYAVEEAAFLVDAVRQHVER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVRLVTPDSTDVPNGDPSNLPAPLKRFRDDVSERMPPGTRVEIGAPGHPPVL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
WVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVIAALFAAWQLQQPLRSLARAV
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
HHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
LRAEMMDDVRLRDGVVRDVDSMSHIVDQFLVFAHGGSDRSEPVPVDQACERIARSYRAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PNAPTVQTRLDADPGFRLPTATLDRILSNLLDNAHAYGAPPVLVETARTPTGYVLSVSDS
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECC
GGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLVLRLGGACDIGNRPEGGLRVS
CCCCCCHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
MTFPFEVVPKDEPHAQAA
EECCEEECCCCCCCCCCC
>Mature Secondary Structure
MRKPIDSLFGRLALLVVGVLLLSHFAWFFAMRLERSQMQTRYAVEEAAFLVDAVRQHVER
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPDQPLPSRVRLVTPDSTDVPNGDPSNLPAPLKRFRDDVSERMPPGTRVEIGAPGHPPVL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
WVKEPTDRNWIVVPVQPLRPPRSLDRMLLWLGTIFSAGVIAALFAAWQLQQPLRSLARAV
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARFGRGQPVPPLRERGPRELRQLTHGFNQMVEQVSQAESDRAVMLAGVAHDLRTPLARMR
HHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
LRAEMMDDVRLRDGVVRDVDSMSHIVDQFLVFAHGGSDRSEPVPVDQACERIARSYRAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
PNAPTVQTRLDADPGFRLPTATLDRILSNLLDNAHAYGAPPVLVETARTPTGYVLSVSDS
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECC
GGGIAPRDLAAATRPFVRLDPARGGNGHSGLGLAIVERLVLRLGGACDIGNRPEGGLRVS
CCCCCCHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
MTFPFEVVPKDEPHAQAA
EECCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]