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The map label for this gene is sugE [H]

Identifier: 78067078

GI number: 78067078

Start: 2707740

End: 2708144

Strand: Reverse

Name: sugE [H]

Synonym: Bcep18194_A5609

Alternate gene names: 78067078

Gene position: 2708144-2707740 (Counterclockwise)

Preceding gene: 78067079

Following gene: 78067077

Centisome position: 73.31

GC content: 66.91

Gene sequence:

>405_bases
TTGTTATACTCGGCGCCGCCCGGGGACGACCCCGGGTCATTCGCTTCAACGGGGACGGCCCCATCCGATACGGAGTACGT
CGAGATGGCGTGGGTATTGTTGTTCATTGCCGGTTTGCTGGAAGTGGCCTGGGCGGCCGGCATGAAATCGTCGGACGGCT
TTACGAAGCTCGGTCCGTCGGTGTTTACGATCGTGACGGCGCTGGCCAGCTTCGGGCTGCTCGCGGTCGCGATGCGCCAG
TTGCCGCTCGGCACCGCGTACGCGGTGTGGACGGGCATCGGCGCGGTCGGTGCGTTCGTGTTCGGCATCGTGATGATGGG
CGAGGCGCTCACCGTCGCGCGGGTCGCGAGCGCCGCGCTGATCGTCGCGGGGCTGATCGGCCTCAAGCTGTCGTCGGCAG
CCTGA

Upstream 100 bases:

>100_bases
GCTGCGTCGGCGGCGCCACGCCGAAGCGCGTATCGAACTGACCGGCCCGGCCGGTCGCCCCCCGATCGGCCGCCGGCCAC
GCGCCGCGTCCGTAAGCATC

Downstream 100 bases:

>100_bases
CGAAGGCAGCCGTGCGCGCCTGCACCCGGCTGCCGCACTGCGGAATTGCGCCGGCCGCCCGCCCAGCCTGTCTATAATGG
AACGCATTCGGGCCTGAATA

Product: small multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MLYSAPPGDDPGSFASTGTAPSDTEYVEMAWVLLFIAGLLEVAWAAGMKSSDGFTKLGPSVFTIVTALASFGLLAVAMRQ
LPLGTAYAVWTGIGAVGAFVFGIVMMGEALTVARVASAALIVAGLIGLKLSSAA

Sequences:

>Translated_134_residues
MLYSAPPGDDPGSFASTGTAPSDTEYVEMAWVLLFIAGLLEVAWAAGMKSSDGFTKLGPSVFTIVTALASFGLLAVAMRQ
LPLGTAYAVWTGIGAVGAFVFGIVMMGEALTVARVASAALIVAGLIGLKLSSAA
>Mature_134_residues
MLYSAPPGDDPGSFASTGTAPSDTEYVEMAWVLLFIAGLLEVAWAAGMKSSDGFTKLGPSVFTIVTALASFGLLAVAMRQ
LPLGTAYAVWTGIGAVGAFVFGIVMMGEALTVARVASAALIVAGLIGLKLSSAA

Specific function: Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082378, Length=104, Percent_Identity=60.5769230769231, Blast_Score=123, Evalue=5e-30,
Organism=Escherichia coli, GI1786755, Length=87, Percent_Identity=40.2298850574713, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 13533; Mature: 13533

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSAPPGDDPGSFASTGTAPSDTEYVEMAWVLLFIAGLLEVAWAAGMKSSDGFTKLGPS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHH
VFTIVTALASFGLLAVAMRQLPLGTAYAVWTGIGAVGAFVFGIVMMGEALTVARVASAAL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAGLIGLKLSSAA
HHHHHHHHHHCCCC
>Mature Secondary Structure
MLYSAPPGDDPGSFASTGTAPSDTEYVEMAWVLLFIAGLLEVAWAAGMKSSDGFTKLGPS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCHH
VFTIVTALASFGLLAVAMRQLPLGTAYAVWTGIGAVGAFVFGIVMMGEALTVARVASAAL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVAGLIGLKLSSAA
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]