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The map label for this gene is nuoF2 [H]

Identifier: 78067041

GI number: 78067041

Start: 2670289

End: 2671599

Strand: Reverse

Name: nuoF2 [H]

Synonym: Bcep18194_A5572

Alternate gene names: 78067041

Gene position: 2671599-2670289 (Counterclockwise)

Preceding gene: 78067042

Following gene: 78067040

Centisome position: 72.32

GC content: 63.92

Gene sequence:

>1311_bases
ATGACGTCCCTCCACGACCGTCACATCAAACCGCTGATCCTCGCTGGTCTGAACGGCGAGAACTGGCATCTCGAAGATTA
CGTTGCGCGCGGCGGCTACAAGCAGCTGCGCCGCATTCTCGAAGAAAAGATTCCGCCCGAGCAGGTGATCGCCGACGTCA
AGGCGTCGGGCCTGCGTGGCCGTGGCGGTGCGGGCTTCCCGACCGGCCTGAAGTGGAGCTTCATGCCGCGTCAGTTCCCG
GGGCAGAAGTACCTCGTCTGCAACTCGGACGAAGGCGAGCCGGGCACGTTCAAGGATCGCGACATCCTGCGCTGGAACCC
GCACGCGCTGATCGAAGGCATGGCCATCGGCGCGTACGCGATGGGCATCACCGTCGGCTACAACTACATCCACGGCGAAA
TCTTCGAAGTGTATCGACGCTTCGAAGCCGCGCTCGATGAAGCGCGCGCTGCCGGGTTCCTCGGCGACAACATCATGGGC
TCGGAATTCTCGTTCCAGCTGCACGCGCACCACGGTTACGGCGCGTACATCTGCGGCGAAGAAACGGCACTGCTCGAGTC
GCTCGAAGGCAAGAAGGGCCAGCCGCGCTTCAAGCCGCCGTTCCCGGCGAGCTTCGGCGTGTACGGCAAGCCCACCACGA
TCAACAACACCGAGACGTTCGCCGCGGTGCCGTTCTTGCTGTCCATCGGGCCGCAGAATTACCTCGAGATCGGCAAGCCG
AACAACGGCGGCACGAAGATTTTCTCGGTGTCGGGCGACGTCGAGCGTCCGGGCAACTATGAAGTGCCGCTCGGCACGCC
GTTCGCGACGCTGATGGAGCTCGCAGGCGGGATGCGCGGCGGCAAGAAGATCAAGGCCGTGATTCCGGGCGGTTCGTCGG
CGCCGGTGATCCCGGGCGACATCATGATGCAGACGGATCTCGACTACGATTCGATCGCGAAGGCGGGCTCGATGCTCGGT
TCCGGCGCGGTGATCGTGATGGACGAGACGCGCTGCATGGTGCGCTCGCTGCTGCGCCTGTCGTACTTCTACTACGAAGA
ATCGTGCGGTCAGTGCACGCCGTGCCGTGAAGGCACCGGCTGGCTGTATCGCGTCGTGAATCGTATCGAGCACGGCGAAG
GCCGCCAGGAAGATCTGGACCTGCTGAACTCGGTTGCCGAGAACATCATGGGCCGCACGATCTGTGCACTCGGCGATGCG
GCGGCGATGCCGGTACGCGGGATGCTCAAGCACTACTGGGACGAATTCGCGTACCACGTCGAGCACAAGCACTGCATGGT
CGGCGGCCACGCGCACGCGGCGGCAGCCTGA

Upstream 100 bases:

>100_bases
GCTCGTGCGGCGATGCGCCGGTGCTGCTGGTGAACAATCACAGAATGTGCAGCTTCATGAGCCGCGAGAAGATCGACCAG
CTGCTTGAGGAGCTCTCGAA

Downstream 100 bases:

>100_bases
AGCGAACCCGGTTGCGGAATTTGAGCGCACGGTCGGGCGAAGGCGCGAACGGGCGGAAATAGGTTAAGGACCATTCACCA
TCATGGTTGAACTTGAAATA

Product: NADH-quinone oxidoreductase, F subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTSLHDRHIKPLILAGLNGENWHLEDYVARGGYKQLRRILEEKIPPEQVIADVKASGLRGRGGAGFPTGLKWSFMPRQFP
GQKYLVCNSDEGEPGTFKDRDILRWNPHALIEGMAIGAYAMGITVGYNYIHGEIFEVYRRFEAALDEARAAGFLGDNIMG
SEFSFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGVYGKPTTINNTETFAAVPFLLSIGPQNYLEIGKP
NNGGTKIFSVSGDVERPGNYEVPLGTPFATLMELAGGMRGGKKIKAVIPGGSSAPVIPGDIMMQTDLDYDSIAKAGSMLG
SGAVIVMDETRCMVRSLLRLSYFYYEESCGQCTPCREGTGWLYRVVNRIEHGEGRQEDLDLLNSVAENIMGRTICALGDA
AAMPVRGMLKHYWDEFAYHVEHKHCMVGGHAHAAAA

Sequences:

>Translated_436_residues
MTSLHDRHIKPLILAGLNGENWHLEDYVARGGYKQLRRILEEKIPPEQVIADVKASGLRGRGGAGFPTGLKWSFMPRQFP
GQKYLVCNSDEGEPGTFKDRDILRWNPHALIEGMAIGAYAMGITVGYNYIHGEIFEVYRRFEAALDEARAAGFLGDNIMG
SEFSFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGVYGKPTTINNTETFAAVPFLLSIGPQNYLEIGKP
NNGGTKIFSVSGDVERPGNYEVPLGTPFATLMELAGGMRGGKKIKAVIPGGSSAPVIPGDIMMQTDLDYDSIAKAGSMLG
SGAVIVMDETRCMVRSLLRLSYFYYEESCGQCTPCREGTGWLYRVVNRIEHGEGRQEDLDLLNSVAENIMGRTICALGDA
AAMPVRGMLKHYWDEFAYHVEHKHCMVGGHAHAAAA
>Mature_435_residues
TSLHDRHIKPLILAGLNGENWHLEDYVARGGYKQLRRILEEKIPPEQVIADVKASGLRGRGGAGFPTGLKWSFMPRQFPG
QKYLVCNSDEGEPGTFKDRDILRWNPHALIEGMAIGAYAMGITVGYNYIHGEIFEVYRRFEAALDEARAAGFLGDNIMGS
EFSFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGVYGKPTTINNTETFAAVPFLLSIGPQNYLEIGKPN
NGGTKIFSVSGDVERPGNYEVPLGTPFATLMELAGGMRGGKKIKAVIPGGSSAPVIPGDIMMQTDLDYDSIAKAGSMLGS
GAVIVMDETRCMVRSLLRLSYFYYEESCGQCTPCREGTGWLYRVVNRIEHGEGRQEDLDLLNSVAENIMGRTICALGDAA
AMPVRGMLKHYWDEFAYHVEHKHCMVGGHAHAAAA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=425, Percent_Identity=45.6470588235294, Blast_Score=377, Evalue=1e-105,
Organism=Homo sapiens, GI20149568, Length=425, Percent_Identity=45.6470588235294, Blast_Score=377, Evalue=1e-105,
Organism=Escherichia coli, GI1788620, Length=402, Percent_Identity=42.5373134328358, Blast_Score=332, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI17531727, Length=430, Percent_Identity=44.1860465116279, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19920794, Length=424, Percent_Identity=43.8679245283019, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI45550452, Length=415, Percent_Identity=43.855421686747, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24653819, Length=398, Percent_Identity=36.6834170854271, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24653817, Length=398, Percent_Identity=32.9145728643216, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47774; Mature: 47643

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLHDRHIKPLILAGLNGENWHLEDYVARGGYKQLRRILEEKIPPEQVIADVKASGLRG
CCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RGGAGFPTGLKWSFMPRQFPGQKYLVCNSDEGEPGTFKDRDILRWNPHALIEGMAIGAYA
CCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHEE
MGITVGYNYIHGEIFEVYRRFEAALDEARAAGFLGDNIMGSEFSFQLHAHHGYGAYICGE
EEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEEECC
ETALLESLEGKKGQPRFKPPFPASFGVYGKPTTINNTETFAAVPFLLSIGPQNYLEIGKP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHEECCCC
NNGGTKIFSVSGDVERPGNYEVPLGTPFATLMELAGGMRGGKKIKAVIPGGSSAPVIPGD
CCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
IMMQTDLDYDSIAKAGSMLGSGAVIVMDETRCMVRSLLRLSYFYYEESCGQCTPCREGTG
EEEEECCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
WLYRVVNRIEHGEGRQEDLDLLNSVAENIMGRTICALGDAAAMPVRGMLKHYWDEFAYHV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHH
EHKHCMVGGHAHAAAA
CCCEEEECCCHHCCCC
>Mature Secondary Structure 
TSLHDRHIKPLILAGLNGENWHLEDYVARGGYKQLRRILEEKIPPEQVIADVKASGLRG
CCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RGGAGFPTGLKWSFMPRQFPGQKYLVCNSDEGEPGTFKDRDILRWNPHALIEGMAIGAYA
CCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHHHEE
MGITVGYNYIHGEIFEVYRRFEAALDEARAAGFLGDNIMGSEFSFQLHAHHGYGAYICGE
EEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEEECC
ETALLESLEGKKGQPRFKPPFPASFGVYGKPTTINNTETFAAVPFLLSIGPQNYLEIGKP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHEECCCC
NNGGTKIFSVSGDVERPGNYEVPLGTPFATLMELAGGMRGGKKIKAVIPGGSSAPVIPGD
CCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
IMMQTDLDYDSIAKAGSMLGSGAVIVMDETRCMVRSLLRLSYFYYEESCGQCTPCREGTG
EEEEECCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
WLYRVVNRIEHGEGRQEDLDLLNSVAENIMGRTICALGDAAAMPVRGMLKHYWDEFAYHV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHH
EHKHCMVGGHAHAAAA
CCCEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]