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The map label for this gene is mmgC [H]

Identifier: 78067028

GI number: 78067028

Start: 2655973

End: 2657106

Strand: Reverse

Name: mmgC [H]

Synonym: Bcep18194_A5559

Alternate gene names: 78067028

Gene position: 2657106-2655973 (Counterclockwise)

Preceding gene: 78067029

Following gene: 78067027

Centisome position: 71.93

GC content: 67.28

Gene sequence:

>1134_bases
ATGGATTTCAGCTTTACCGATGAGCAGCAGCAGTTTGCCGATGCGCTGCGCCGTTATCTCGGCGAGCAATACGGCTTCGA
AGCGCGCCAGGCAATCGTGCACAGCGATGCGGGCGTGTCGGACACGCAATGGAGCGCGTTCGCCGAACTGGGGTTGACCG
CGCTGCCCGTGCCGGACGCGCAGGGTGGCTTCGGCGGCGGCCCGGTCGACATGCTGGTCGTGATGCAGGAACTCGGCCGC
GCGCTCGTGATCGAGCCGCACTGGGCAACGGCAGTGGGCGTCGAAGCCTTGCGTATCGCCGGCTCGAGCGCCGGCGAGGA
TGCGGTGCTGCTGGAGGCGATCGCGCAGGGGCAGAAGCGCGTGGCGGTTGCGTTCCACGAACCGCATGCGCGCTACGACC
TGTTCGAACTCGACACGCATGCGCGTGAGCAGGGCGGCACGTACCGGCTGACCGGCACGAAGTCGGTCGTTCAGCATGGT
GCACAGGCGGATGTGTGGATCGTGCCCGCACGTGTCGACGGCGGCGGTATCGGCCTCTTCGTCGTCGACCGGAATGCCGC
AAACGCGAAGGTGGCCGACTACCGGACGATCGACGGTCAGCGTGCCGCGACGATCGGGTTCGACGAAACGCCGGCGCGAC
TGCTGACGGGCGGTGCGCGCGACGCTGCGGCCCTCGAGCAGGTTGCCGATTACGCGACGTTCCTGCTGTGCGCGGAAGCG
GTCGGCGTACTCGACGAACTGAACCGTGCCACGGTCGAATACACGAAGACACGCGAACAGTTCGGCGTGCCGATCGCACG
TTTCCAGGCGCTGCAGCACCGGATGGTCGACATGCTGATCCATGCCGAGCAGGCGCGTTCGCTGACCTACCTGGCTGCCG
TACGCTACGCGAGCGGCGATGCTGATGCGCGGCGCAAGGCCGTGTCGGCCGCGAAAGCACGTGTCGGCGCCGCCGCGCGC
TTCGTCGGCCAGCAGGCCGTTCAACTGCACGGCGGCATGGGCGTGACCAACGAGGTCGCCGCCGCGCATCTGTTCAAGCG
GCTGACGATCATCGAGACGACGCTCGGCGACACCGATCATCATCTCGCCCGTATCGCGGCGCTGCCCGATTTCGCGCAGA
CCGACGAGGCATGA

Upstream 100 bases:

>100_bases
AATTACCGGAAGACGTCGATCTACGGCGGCTCGAACGAGATCCAGAAGAACATCATCGCGCAGATGATTCTGGGGCTGTG
ATCAGGGAACGGAGACAACC

Downstream 100 bases:

>100_bases
CGGTGACGCGCGAGCGCGCCAGACAAGGAGACACCTAGTGGGCATCAGTTACGAAGACCTGGTGGTCGGCAGCACCACCG
AAGTGGGCCGTTACACGTTC

Product: Acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVHSDAGVSDTQWSAFAELGLTALPVPDAQGGFGGGPVDMLVVMQELGR
ALVIEPHWATAVGVEALRIAGSSAGEDAVLLEAIAQGQKRVAVAFHEPHARYDLFELDTHAREQGGTYRLTGTKSVVQHG
AQADVWIVPARVDGGGIGLFVVDRNAANAKVADYRTIDGQRAATIGFDETPARLLTGGARDAAALEQVADYATFLLCAEA
VGVLDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYASGDADARRKAVSAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLTIIETTLGDTDHHLARIAALPDFAQTDEA

Sequences:

>Translated_377_residues
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVHSDAGVSDTQWSAFAELGLTALPVPDAQGGFGGGPVDMLVVMQELGR
ALVIEPHWATAVGVEALRIAGSSAGEDAVLLEAIAQGQKRVAVAFHEPHARYDLFELDTHAREQGGTYRLTGTKSVVQHG
AQADVWIVPARVDGGGIGLFVVDRNAANAKVADYRTIDGQRAATIGFDETPARLLTGGARDAAALEQVADYATFLLCAEA
VGVLDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYASGDADARRKAVSAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLTIIETTLGDTDHHLARIAALPDFAQTDEA
>Mature_377_residues
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVHSDAGVSDTQWSAFAELGLTALPVPDAQGGFGGGPVDMLVVMQELGR
ALVIEPHWATAVGVEALRIAGSSAGEDAVLLEAIAQGQKRVAVAFHEPHARYDLFELDTHAREQGGTYRLTGTKSVVQHG
AQADVWIVPARVDGGGIGLFVVDRNAANAKVADYRTIDGQRAATIGFDETPARLLTGGARDAAALEQVADYATFLLCAEA
VGVLDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYASGDADARRKAVSAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLTIIETTLGDTDHHLARIAALPDFAQTDEA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=372, Percent_Identity=23.9247311827957, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=25.0728862973761, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4557233, Length=326, Percent_Identity=26.0736196319018, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI21361497, Length=377, Percent_Identity=24.4031830238727, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501859, Length=380, Percent_Identity=23.9473684210526, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI187960098, Length=394, Percent_Identity=23.8578680203046, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4557231, Length=394, Percent_Identity=23.8578680203046, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4501857, Length=359, Percent_Identity=23.1197771587744, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=23.6979166666667, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=23.6559139784946, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17506239, Length=382, Percent_Identity=26.4397905759162, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=345, Percent_Identity=24.6376811594203, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=336, Percent_Identity=25.8928571428571, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=337, Percent_Identity=25.5192878338279, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355753, Length=334, Percent_Identity=25.748502994012, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646207, Length=327, Percent_Identity=25.6880733944954, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356377, Length=337, Percent_Identity=24.9258160237389, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666513, Length=336, Percent_Identity=27.9761904761905, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24660351, Length=388, Percent_Identity=24.2268041237113, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40409; Mature: 40409

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVHSDAGVSDTQWSAFAELGLTALPVPDA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCCCEEECCCCC
QGGFGGGPVDMLVVMQELGRALVIEPHWATAVGVEALRIAGSSAGEDAVLLEAIAQGQKR
CCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCE
VAVAFHEPHARYDLFELDTHAREQGGTYRLTGTKSVVQHGAQADVWIVPARVDGGGIGLF
EEEEEECCCCCCEEEECCHHHHHCCCEEEEECCHHHHHCCCCCCEEEEEEEECCCEEEEE
VVDRNAANAKVADYRTIDGQRAATIGFDETPARLLTGGARDAAALEQVADYATFLLCAEA
EEECCCCCCEECCEEECCCCCEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VGVLDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYASGD
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ADARRKAVSAAKARVGAAARFVGQQAVQLHGGMGVTNEVAAAHLFKRLTIIETTLGDTDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
HLARIAALPDFAQTDEA
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDFSFTDEQQQFADALRRYLGEQYGFEARQAIVHSDAGVSDTQWSAFAELGLTALPVPDA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCCCEEECCCCC
QGGFGGGPVDMLVVMQELGRALVIEPHWATAVGVEALRIAGSSAGEDAVLLEAIAQGQKR
CCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCE
VAVAFHEPHARYDLFELDTHAREQGGTYRLTGTKSVVQHGAQADVWIVPARVDGGGIGLF
EEEEEECCCCCCEEEECCHHHHHCCCEEEEECCHHHHHCCCCCCEEEEEEEECCCEEEEE
VVDRNAANAKVADYRTIDGQRAATIGFDETPARLLTGGARDAAALEQVADYATFLLCAEA
EEECCCCCCEECCEEECCCCCEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VGVLDELNRATVEYTKTREQFGVPIARFQALQHRMVDMLIHAEQARSLTYLAAVRYASGD
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ADARRKAVSAAKARVGAAARFVGQQAVQLHGGMGVTNEVAAAHLFKRLTIIETTLGDTDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
HLARIAALPDFAQTDEA
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]