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The map label for this gene is uvrB [H]

Identifier: 78067007

GI number: 78067007

Start: 2630802

End: 2632925

Strand: Reverse

Name: uvrB [H]

Synonym: Bcep18194_A5538

Alternate gene names: 78067007

Gene position: 2632925-2630802 (Counterclockwise)

Preceding gene: 78067009

Following gene: 78067006

Centisome position: 71.27

GC content: 63.84

Gene sequence:

>2124_bases
ATGCTTTCTTTGCCCTCGCTCCGGCCGCATTCCATGTACGAACATAAAGCCGAAACCGGCGACGCGCTCGACGAATCGAA
ATTCGTGACCTTCGAAGGGTCGCCGTTCCAGCTGTATCAACCGTATCCGCCCGCAGGCGACCAGCCGACCGCGATCGAGA
CGCTCGTCGAAGGGGTCGAGGACGGTCTCTCGTTCCAGACGCTGCTCGGCGTGACGGGCTCGGGCAAGACCTTCACGATG
GCGAACACGATCGCGCGACTCGGCCGCCCGGCGATCGTGTTCGCGCCGAACAAGACGCTCGCCGCTCAGCTCTACTCGGA
ATTTCGCGAGTTCTTCCCGCGCAACGCGGTCGAGTACTTCGTCTCGTACTACGACTATTACCAGCCTGAAGCGTATGTGC
CGCAGCGCGACCTGTTCATCGAGAAGGACTCGTCGATCAACGAGCACATCGAGCAGATGCGGCTGTCGGCGACGAAGAGC
CTGATGGAGCGTCGCGATGTCGTGATCGTCGCGACGGTGTCGGCGATCTACGGTATCGGCAACCCGTCCGAATACCACCA
GATGATCCTGACGCTGCGCGCCGGCGACAAGCTCGGCCAGCGCGACGTGATCGCGCGGCTGATCGCGATGCAGTACACAC
GCAACGAGCAGGATTTCCAGCGCGGCACGTTCCGCGTGCGCGGCGACACGATCGACATCTTCCCGGCCGAACATGCGGAG
CTGGCCGTGCGCGTCGAATTGTTCGACGACGAGGTGGAGACGCTGCAGCTGTTCGACCCGCTGACCGGGCGCGTACGGCA
GAAGATCCCGCGCTTCACCGTGTATCCGTCGTCGCACTACGTGACGCCGCGCGACACCGTGATGCGCGCGGTCGAGACGA
TCAAGGACGAACTGCGCGAGCGGCTCGAGTTCTTTCACAGCGACGGCAAGCTCGTCGAGGCGCAGCGCCTCGAGCAGCGC
ACGCGCTTCGATCTCGAGATGCTGCAGGAGCTCGGCTTCTGCAAGGGCATCGAGAACTACTCGCGGCATTTCTCGGGCGC
GTCGCCCGGCGATCCGCCGCCGACCCTCGTCGACTACCTGCCGCCCGATGCGCTGATGCTGCTCGACGAATCGCACGTGC
TGATCGGCCAGTTGAACGGCATGTACAACGGCGATCGCGCGCGCAAGGAAAACCTCGTCAACTACGGGTTCCGGTTGCCG
TCGGCGCTGGACAACCGGCCGCTCAAGTTCCCGGAGTTCGAACGCAAGATGCGCCAGGTCGTGTTCGTGTCGGCTACGCC
GGCCGACTACGAGAAGCGCGTGACCGGGCAGATCGCCGAACAGGTCGTGCGGCCGACGGGCCTTGTCGATCCGGAAATCG
AAGTGCGGCCGGCGAGCTCGCAAGTCGACGACGTGCTGGCCGAGATCAATGCGCGCGTGAAGGCCGAGGAGCGTGTGCTG
ATCACCGTGTTGACGAAGCGCATGGCCGAGCAGCTCACCGAGTTTCTCGCCGATCACGGGGTCAAGGTGCGTTACCTGCA
CAGCGACATCGACACGGTCGAGCGCGTCGAGATCATCCGCGACCTGCGGCTCGGCACGTTCGACGTGCTGGTCGGGATCA
ACCTGCTGCGGGAAGGGCTCGATATTCCCGAAGTGTCGCTCGTCGCGATCCTCGACGCGGACAAGGAAGGCTTCCTACGC
GCCGAGCGCTCGCTGATCCAGACGATCGGCCGTGCGGCCCGGAACGTGAACGGCAAGGCGATCCTCTACGCGGACAACAT
GACCGAGTCGATGAAGCGCGCGATCGGCGAGACCGAGCGGCGCCGTGCGAAGCAGATCGCGCACAACGAAAAGATGGGCA
TCACGCCGCGCGGTGTCGTGAAGCGCATCAAGGACATCATCGACGGCGTCTACAACGCGGACGAGGCACGCGCCGAGCTG
AAGGAAGCGCAGCAGCGCGCCAAATTCGAGGACATGTCGGAAAAGCAGCTCGCCAAGGAAATCAAGCGCCTCGAGAAGCA
GATGGCCGACTACGCGAAGAATCTCGAGTTCGAGAAGGCAGCCTCGACTCGCGACCAGCTTGCGCTGCTTCGTGAGCGCG
TGTTCGGTGCGAACGTCGGCGATCACATCAACGGCGGCCGGTAA

Upstream 100 bases:

>100_bases
GGCGGCGAATCGGTGGCGAAATTCGGCGGCAAATCGAGATGCCGGGCGGCCGCCGCGCGTCAGGAGCCGACAGCAGTTCG
CGACGCCGCGAAGCGCTAGA

Downstream 100 bases:

>100_bases
TTCTTTCCAAGCGTCACCGAAACCCGGAGGTAACGAGCCTGTAAGCCTTGTCGGATCAGGGGTTTACACGGCTCCCCGTT
TGTTCCGAAACAGGTTCGGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 707; Mature: 707

Protein sequence:

>707_residues
MLSLPSLRPHSMYEHKAETGDALDESKFVTFEGSPFQLYQPYPPAGDQPTAIETLVEGVEDGLSFQTLLGVTGSGKTFTM
ANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKS
LMERRDVVIVATVSAIYGIGNPSEYHQMILTLRAGDKLGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
LAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIKDELRERLEFFHSDGKLVEAQRLEQR
TRFDLEMLQELGFCKGIENYSRHFSGASPGDPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLP
SALDNRPLKFPEFERKMRQVVFVSATPADYEKRVTGQIAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINARVKAEERVL
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLR
AERSLIQTIGRAARNVNGKAILYADNMTESMKRAIGETERRRAKQIAHNEKMGITPRGVVKRIKDIIDGVYNADEARAEL
KEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAASTRDQLALLRERVFGANVGDHINGGR

Sequences:

>Translated_707_residues
MLSLPSLRPHSMYEHKAETGDALDESKFVTFEGSPFQLYQPYPPAGDQPTAIETLVEGVEDGLSFQTLLGVTGSGKTFTM
ANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKS
LMERRDVVIVATVSAIYGIGNPSEYHQMILTLRAGDKLGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
LAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIKDELRERLEFFHSDGKLVEAQRLEQR
TRFDLEMLQELGFCKGIENYSRHFSGASPGDPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLP
SALDNRPLKFPEFERKMRQVVFVSATPADYEKRVTGQIAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINARVKAEERVL
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLR
AERSLIQTIGRAARNVNGKAILYADNMTESMKRAIGETERRRAKQIAHNEKMGITPRGVVKRIKDIIDGVYNADEARAEL
KEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAASTRDQLALLRERVFGANVGDHINGGR
>Mature_707_residues
MLSLPSLRPHSMYEHKAETGDALDESKFVTFEGSPFQLYQPYPPAGDQPTAIETLVEGVEDGLSFQTLLGVTGSGKTFTM
ANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKS
LMERRDVVIVATVSAIYGIGNPSEYHQMILTLRAGDKLGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
LAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIKDELRERLEFFHSDGKLVEAQRLEQR
TRFDLEMLQELGFCKGIENYSRHFSGASPGDPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLP
SALDNRPLKFPEFERKMRQVVFVSATPADYEKRVTGQIAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINARVKAEERVL
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLR
AERSLIQTIGRAARNVNGKAILYADNMTESMKRAIGETERRRAKQIAHNEKMGITPRGVVKRIKDIIDGVYNADEARAEL
KEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAASTRDQLALLRERVFGANVGDHINGGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=65.424739195231, Blast_Score=868, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.1270358306189, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80346; Mature: 80346

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLPSLRPHSMYEHKAETGDALDESKFVTFEGSPFQLYQPYPPAGDQPTAIETLVEGVE
CCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHH
DGLSFQTLLGVTGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYF
CCCCHHHHHCCCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHH
VSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIG
HHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCC
NPSEYHQMILTLRAGDKLGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
CHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEECCEEEECCCCCCC
LAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIKDELRE
EEEEEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
RLEFFHSDGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGASPGDPPPTLVDYL
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCC
PPDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFPEFERKMRQV
CCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHE
VFVSATPADYEKRVTGQIAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINARVKAEERVL
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCHHHH
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKAILYADNMTESMKRAIGETER
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCHHHH
RRAKQIAHNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDMSEKQLAKE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IKRLEKQMADYAKNLEFEKAASTRDQLALLRERVFGANVGDHINGGR
HHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLSLPSLRPHSMYEHKAETGDALDESKFVTFEGSPFQLYQPYPPAGDQPTAIETLVEGVE
CCCCCCCCCCHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHH
DGLSFQTLLGVTGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYSEFREFFPRNAVEYF
CCCCHHHHHCCCCCCCEEHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHH
VSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIG
HHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCC
NPSEYHQMILTLRAGDKLGQRDVIARLIAMQYTRNEQDFQRGTFRVRGDTIDIFPAEHAE
CHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEEECCEEEECCCCCCC
LAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIKDELRE
EEEEEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
RLEFFHSDGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGASPGDPPPTLVDYL
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHCC
PPDALMLLDESHVLIGQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFPEFERKMRQV
CCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHE
VFVSATPADYEKRVTGQIAEQVVRPTGLVDPEIEVRPASSQVDDVLAEINARVKAEERVL
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCHHHH
ITVLTKRMAEQLTEFLADHGVKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKAILYADNMTESMKRAIGETER
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHCHHHH
RRAKQIAHNEKMGITPRGVVKRIKDIIDGVYNADEARAELKEAQQRAKFEDMSEKQLAKE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IKRLEKQMADYAKNLEFEKAASTRDQLALLRERVFGANVGDHINGGR
HHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA