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The map label for this gene is aceE

Identifier: 78066912

GI number: 78066912

Start: 2513298

End: 2515994

Strand: Reverse

Name: aceE

Synonym: Bcep18194_A5443

Alternate gene names: 78066912

Gene position: 2515994-2513298 (Counterclockwise)

Preceding gene: 161702956

Following gene: 78066911

Centisome position: 68.11

GC content: 64.48

Gene sequence:

>2697_bases
ATGTCCGCTGTACCGAACGAAGTGATGAAATATGTCGCCGCCGAACGTGACGACGACCCGCAAGAAACCGTCGAGTGGCT
GGAGTCGCTCGATGGCGTGATCTCCTCCGTGGGCACCGGCCGTGCGCATTACCTGATCGAAAAGCAGATCGAGTTCGCCC
GCATGCACGGCGAACACCTGCCGTTCTCCGCCAACACCCCGTACATCAACACGATCCCGGTCGCCGCGCAGGCGAAGATC
CCGGGCGACCAGGACCTCGAGCACCGCATCCGTTCGTACACGCGCTGGAACGCGCTGGCGATGGTGCTGCGCGCAGGCAA
GGACACGAACGTCGGCGGCCACATCGCCTCGTTCGCATCGGCCGCGACGCTCTATGACGTCGGCTACAACCACTTCTGGC
ACGCAGCGTCCGAGCAGCACGGCGGCGATCTCGTGTTCGTGCAGGGCCACTCGTCGCCGGGCGTGTACTCGCGCGCGTTC
CTGCTCGGCCGCCTGAAGGAAGAGCAGCTCGACAACTTCCGCCAGGAAGTCGACGGCCAGGGCATTTCGTCGTACCCGCA
CCCGTGGCTGATGCCGGACTTCTGGCAGTTCCCGACCGTGTCGATGGGTCTCGGCCCGATCATGGCGATCTACCAGGCGC
GCTTCATGAAGTACCTGCAGGCGCGCGGCATCACGAAGACCGAAGGCCGCAAGGTGTGGGCATTCCTCGGCGACGGCGAG
ACGGACGAGCCGGAATCGCTCGGCGCGATCGGGATGGCGAGCCGCGAGAAGCTCGACAACCTCGTGTTCGTGATCAACTG
CAACCTGCAGCGTCTCGACGGCCCGGTGCGCGGCAACGGCAAGATCATCCAGGAACTCGAATCGGAGTTCCGCGGCGCCG
GCTGGAACGTGATCAAGGTCATCTGGGGCAGCCGCTGGGATGCGCTGTTCGCACGCGACAAGTCGGGCGCGCTGATGCGC
CGCATGATGGAAGCCGTCGACGGCGAATACCAGACGTACAAGTCGGAGTCGGGCGCATTCGTGCGCGAGCACTTCTTCAA
CACGCCTGAGCTGAAGGCACTCGTCGCCGACTGGTCGGACGACGACATCTGGGCGCTGAACCGCGGCGGCCACGATCCGC
ACAAGATCTACGCGGCGTTCCACGAAGCCACGAACACGAAGGGCGCGCCGACCGTCATCCTCGCGAAGACCATCAAGGGC
TACGGGATGGGCGAGTCGGGCCAGGCGATGAACATCACGCACCAGCAGAAGAAGCTGCCGGTCGAGCAACTGAAGAAGTT
CCGTGACCAGTTCCGCCTGCCGATCACCGACGAGCAGATCGCCGACGTGCCGTACCTGAAGTTCGAGGAAGGCTCGAAGG
AACTCGAATACATGCGCCAGAAGCGCATGGACCTCGGCGGCTACCTGCCGCATCGCCGCGAGAAGGCGACGTCGCTGCCG
GTGCCGGCGCTCGACGTGTTCGAGCCGCTGCTGAAGGGCACGGGCGAAGGCCGTGAGATCTCGACGACGATGTCGTTCGT
GCGGATCCTGAACATCCTGCTGAAGGACAAGGCGCTGGGCAAGCGCATCGTGCCGATCGTCCCGGACGAATCGCGTACGT
TCGGCATGGAAGGCCTGTTCCGCCAGATCGGTATCTGGAACCAGGAAGGCCAGAAGTACGTGCCGGAAGATTCCGACCAG
CTGATGTTCTACAAGGAATCGGAAACCGGCCAGATCCTGCAGGAAGGCATCAACGAAGCGGGCGGCATGTGCGACTGGAT
CGCTGCGGCGACGTCGTACTCGACGCACGGCGAGATCATGGTGCCGTTCTACATCTTCTATTCGATGTTCGGCTTCCAGC
GGATCGGCGACCTGGCATGGGCCGCGGGCGACATGCGTTCGCGCGGCTTCCTGCTCGGCGGTACCGCGGGCCGCACGACG
CTGAACGGCGAAGGCCTGCAGCACGAAGACGGCCACTCGCTCCTGTGGGCGGCATCGGTGCCGAACTGCGTGAGCTACGA
CCCGACCTTCGGCTACGAACTCGCCGTGATCGTCCAGGACGGCCTGCGCCGCATGGTGGCGGACCAGGAAGACGTGTACT
ACTACATCACGGTGATGAACGAGAACTACGAGCACCCGGCGATTCCGCAGGGCGAGCACGTGGCGGCCGACATCATCAAG
GGCATGTACGCGTTCAAGAAGGCCGACGCCGACAAGAAGGCGCCGCGCGTCCAGCTGCTCGGCGCGGGCACGATCTTCAA
CGAAGTGATCGCTGCCGCCGACCTGCTGAAGAACGACTGGGGCGTCGCTGCCGACCTGTGGAGCGTGCCGAGCTTCACCG
AGCTCGCGCGTGAAGGCCACCAGGTCGAACGCTGGAACCTGCTCCATCCGACCGAAGAGCGTCGTCTGTCGCACGTGCAG
AAGTGCCTGAAGGACACGCAGGGCCCGGTCATCGCATCGACCGACTACGTCCGCGCGCTGGTCGACCAGATCCGCGGCCA
GATCGATCGCCGCTTCGTCGTGCTGGGCACGGACGGCTTCGGCCGCTCGGATACCCGCGAGAAGCTGCGTCACTTCTTCG
AAGTCGACCGTCACTGGGTCACCGTCGCCGCGCTCAATGCGCTGGCCGACGAGGGCACGATCGAGCGCAAGGTGGTCGCG
GAAGCGATCGCCAAGTACAACCTCGATCCGTCGAAGCCCAACCCGATGACCGTTTAA

Upstream 100 bases:

>100_bases
GTGCACGCTCATTACAATCCGTCGGAGCTTGCCCGCAGCCGGTCGCGTCGCGTCGTCTGCACGAGAGCGATCCTCACATT
CCAGGACCCAGGAGACGAGA

Downstream 100 bases:

>100_bases
CGCACACGCCGTGTGATGCCGCGCGCCGCTCCCGCGAGGGGCGCGCGCGGTCATGGAGACAGAAACAGATGAGTCAAGCG
ATCGAAGTGAAGGTGCCGGA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 898; Mature: 897

Protein sequence:

>898_residues
MSAVPNEVMKYVAAERDDDPQETVEWLESLDGVISSVGTGRAHYLIEKQIEFARMHGEHLPFSANTPYINTIPVAAQAKI
PGDQDLEHRIRSYTRWNALAMVLRAGKDTNVGGHIASFASAATLYDVGYNHFWHAASEQHGGDLVFVQGHSSPGVYSRAF
LLGRLKEEQLDNFRQEVDGQGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLQARGITKTEGRKVWAFLGDGE
TDEPESLGAIGMASREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDALFARDKSGALMR
RMMEAVDGEYQTYKSESGAFVREHFFNTPELKALVADWSDDDIWALNRGGHDPHKIYAAFHEATNTKGAPTVILAKTIKG
YGMGESGQAMNITHQQKKLPVEQLKKFRDQFRLPITDEQIADVPYLKFEEGSKELEYMRQKRMDLGGYLPHRREKATSLP
VPALDVFEPLLKGTGEGREISTTMSFVRILNILLKDKALGKRIVPIVPDESRTFGMEGLFRQIGIWNQEGQKYVPEDSDQ
LMFYKESETGQILQEGINEAGGMCDWIAAATSYSTHGEIMVPFYIFYSMFGFQRIGDLAWAAGDMRSRGFLLGGTAGRTT
LNGEGLQHEDGHSLLWAASVPNCVSYDPTFGYELAVIVQDGLRRMVADQEDVYYYITVMNENYEHPAIPQGEHVAADIIK
GMYAFKKADADKKAPRVQLLGAGTIFNEVIAAADLLKNDWGVAADLWSVPSFTELAREGHQVERWNLLHPTEERRLSHVQ
KCLKDTQGPVIASTDYVRALVDQIRGQIDRRFVVLGTDGFGRSDTREKLRHFFEVDRHWVTVAALNALADEGTIERKVVA
EAIAKYNLDPSKPNPMTV

Sequences:

>Translated_898_residues
MSAVPNEVMKYVAAERDDDPQETVEWLESLDGVISSVGTGRAHYLIEKQIEFARMHGEHLPFSANTPYINTIPVAAQAKI
PGDQDLEHRIRSYTRWNALAMVLRAGKDTNVGGHIASFASAATLYDVGYNHFWHAASEQHGGDLVFVQGHSSPGVYSRAF
LLGRLKEEQLDNFRQEVDGQGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLQARGITKTEGRKVWAFLGDGE
TDEPESLGAIGMASREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDALFARDKSGALMR
RMMEAVDGEYQTYKSESGAFVREHFFNTPELKALVADWSDDDIWALNRGGHDPHKIYAAFHEATNTKGAPTVILAKTIKG
YGMGESGQAMNITHQQKKLPVEQLKKFRDQFRLPITDEQIADVPYLKFEEGSKELEYMRQKRMDLGGYLPHRREKATSLP
VPALDVFEPLLKGTGEGREISTTMSFVRILNILLKDKALGKRIVPIVPDESRTFGMEGLFRQIGIWNQEGQKYVPEDSDQ
LMFYKESETGQILQEGINEAGGMCDWIAAATSYSTHGEIMVPFYIFYSMFGFQRIGDLAWAAGDMRSRGFLLGGTAGRTT
LNGEGLQHEDGHSLLWAASVPNCVSYDPTFGYELAVIVQDGLRRMVADQEDVYYYITVMNENYEHPAIPQGEHVAADIIK
GMYAFKKADADKKAPRVQLLGAGTIFNEVIAAADLLKNDWGVAADLWSVPSFTELAREGHQVERWNLLHPTEERRLSHVQ
KCLKDTQGPVIASTDYVRALVDQIRGQIDRRFVVLGTDGFGRSDTREKLRHFFEVDRHWVTVAALNALADEGTIERKVVA
EAIAKYNLDPSKPNPMTV
>Mature_897_residues
SAVPNEVMKYVAAERDDDPQETVEWLESLDGVISSVGTGRAHYLIEKQIEFARMHGEHLPFSANTPYINTIPVAAQAKIP
GDQDLEHRIRSYTRWNALAMVLRAGKDTNVGGHIASFASAATLYDVGYNHFWHAASEQHGGDLVFVQGHSSPGVYSRAFL
LGRLKEEQLDNFRQEVDGQGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLQARGITKTEGRKVWAFLGDGET
DEPESLGAIGMASREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDALFARDKSGALMRR
MMEAVDGEYQTYKSESGAFVREHFFNTPELKALVADWSDDDIWALNRGGHDPHKIYAAFHEATNTKGAPTVILAKTIKGY
GMGESGQAMNITHQQKKLPVEQLKKFRDQFRLPITDEQIADVPYLKFEEGSKELEYMRQKRMDLGGYLPHRREKATSLPV
PALDVFEPLLKGTGEGREISTTMSFVRILNILLKDKALGKRIVPIVPDESRTFGMEGLFRQIGIWNQEGQKYVPEDSDQL
MFYKESETGQILQEGINEAGGMCDWIAAATSYSTHGEIMVPFYIFYSMFGFQRIGDLAWAAGDMRSRGFLLGGTAGRTTL
NGEGLQHEDGHSLLWAASVPNCVSYDPTFGYELAVIVQDGLRRMVADQEDVYYYITVMNENYEHPAIPQGEHVAADIIKG
MYAFKKADADKKAPRVQLLGAGTIFNEVIAAADLLKNDWGVAADLWSVPSFTELAREGHQVERWNLLHPTEERRLSHVQK
CLKDTQGPVIASTDYVRALVDQIRGQIDRRFVVLGTDGFGRSDTREKLRHFFEVDRHWVTVAALNALADEGTIERKVVAE
AIAKYNLDPSKPNPMTV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=885, Percent_Identity=59.4350282485876, Blast_Score=1080, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100792; Mature: 100661

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVPNEVMKYVAAERDDDPQETVEWLESLDGVISSVGTGRAHYLIEKQIEFARMHGEHL
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
PFSANTPYINTIPVAAQAKIPGDQDLEHRIRSYTRWNALAMVLRAGKDTNVGGHIASFAS
CCCCCCCEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AATLYDVGYNHFWHAASEQHGGDLVFVQGHSSPGVYSRAFLLGRLKEEQLDNFRQEVDGQ
HHHHHHCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLQARGITKTEGRKVWAFLGDGE
CCCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
TDEPESLGAIGMASREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKV
CCCCHHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
IWGSRWDALFARDKSGALMRRMMEAVDGEYQTYKSESGAFVREHFFNTPELKALVADWSD
ECCCCCHHHEECCCCCHHHHHHHHHHCCCHHHHCCCCCCHHHHHCCCCCHHHEEEECCCC
DDIWALNRGGHDPHKIYAAFHEATNTKGAPTVILAKTIKGYGMGESGQAMNITHQQKKLP
CCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCCCEECCCHHHHCCC
VEQLKKFRDQFRLPITDEQIADVPYLKFEEGSKELEYMRQKRMDLGGYLPHRREKATSLP
HHHHHHHHHHCCCCCCCHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCC
VPALDVFEPLLKGTGEGREISTTMSFVRILNILLKDKALGKRIVPIVPDESRTFGMEGLF
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHH
RQIGIWNQEGQKYVPEDSDQLMFYKESETGQILQEGINEAGGMCDWIAAATSYSTHGEIM
HHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEE
VPFYIFYSMFGFQRIGDLAWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSLLWAASV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCCCCCCCCCCEEEEECCC
PNCVSYDPTFGYELAVIVQDGLRRMVADQEDVYYYITVMNENYEHPAIPQGEHVAADIIK
CCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHH
GMYAFKKADADKKAPRVQLLGAGTIFNEVIAAADLLKNDWGVAADLWSVPSFTELAREGH
HHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHCCC
QVERWNLLHPTEERRLSHVQKCLKDTQGPVIASTDYVRALVDQIRGQIDRRFVVLGTDGF
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCEEEEEECCCC
GRSDTREKLRHFFEVDRHWVTVAALNALADEGTIERKVVAEAIAKYNLDPSKPNPMTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVPNEVMKYVAAERDDDPQETVEWLESLDGVISSVGTGRAHYLIEKQIEFARMHGEHL
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
PFSANTPYINTIPVAAQAKIPGDQDLEHRIRSYTRWNALAMVLRAGKDTNVGGHIASFAS
CCCCCCCEEEEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AATLYDVGYNHFWHAASEQHGGDLVFVQGHSSPGVYSRAFLLGRLKEEQLDNFRQEVDGQ
HHHHHHCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFMKYLQARGITKTEGRKVWAFLGDGE
CCCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
TDEPESLGAIGMASREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKV
CCCCHHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
IWGSRWDALFARDKSGALMRRMMEAVDGEYQTYKSESGAFVREHFFNTPELKALVADWSD
ECCCCCHHHEECCCCCHHHHHHHHHHCCCHHHHCCCCCCHHHHHCCCCCHHHEEEECCCC
DDIWALNRGGHDPHKIYAAFHEATNTKGAPTVILAKTIKGYGMGESGQAMNITHQQKKLP
CCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEHHCCCCCCCCCCEECCCHHHHCCC
VEQLKKFRDQFRLPITDEQIADVPYLKFEEGSKELEYMRQKRMDLGGYLPHRREKATSLP
HHHHHHHHHHCCCCCCCHHHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCC
VPALDVFEPLLKGTGEGREISTTMSFVRILNILLKDKALGKRIVPIVPDESRTFGMEGLF
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHH
RQIGIWNQEGQKYVPEDSDQLMFYKESETGQILQEGINEAGGMCDWIAAATSYSTHGEIM
HHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEE
VPFYIFYSMFGFQRIGDLAWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSLLWAASV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCCCCCCCCCCEEEEECCC
PNCVSYDPTFGYELAVIVQDGLRRMVADQEDVYYYITVMNENYEHPAIPQGEHVAADIIK
CCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHH
GMYAFKKADADKKAPRVQLLGAGTIFNEVIAAADLLKNDWGVAADLWSVPSFTELAREGH
HHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHCCC
QVERWNLLHPTEERRLSHVQKCLKDTQGPVIASTDYVRALVDQIRGQIDRRFVVLGTDGF
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCEEEEEECCCC
GRSDTREKLRHFFEVDRHWVTVAALNALADEGTIERKVVAEAIAKYNLDPSKPNPMTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]