Click here to switch to the map view.

The map label for this gene is dapA

Identifier: 78066870

GI number: 78066870

Start: 2469395

End: 2470300

Strand: Reverse

Name: dapA

Synonym: Bcep18194_A5401

Alternate gene names: 78066870

Gene position: 2470300-2469395 (Counterclockwise)

Preceding gene: 78066871

Following gene: 78066869

Centisome position: 66.87

GC content: 66.23

Gene sequence:

>906_bases
ATGGCTAACGGCACCCAAGACGGCATTCAAATCCGCGGCAGCATCCCCGCGATCGTCACCCCGATGCTCGAAGACGGCAG
TCTCGACCTGCCGGCGTTTCGCAAACTGATCGACTGGCATATCGCGGAAGGCACCGATGCGCTCGTCGTGGTCGGTACGA
GCGGCGAGTCGGCAACGCTCAACGTCGAAGAGCACATCCTGATGATCCGCACGGCGGTCGAGCATGCGGCGAAACGCATC
CCGATCATCGCGGGCGCGGGCGGCAACTCGACCGCCGAGGCGATCGAGCTGACGAAGCACGCGAAGGCTGTCGGCGCGGA
CGCGACGCTGCAGGTCGTGCCGTACTACAACAAGCCGACGCAGGAAGGCATGTACCGTCACTTCAAGACGATCGCCGAAG
CGGTCGATCTTCCGGTGATCCTGTACAACGTGCCGGGCCGCACGGTCGCCGACATGGCGAACGAGACGACGCTGCGCCTC
GCGGAAGTCCCGGGCATCATCGGCGTGAAGGAAGCGACCGGCAACATCGATCGCGCCGCGCACCTGATCAAGGCCGCGCC
GAAGCATTTCGCGATCTACAGCGGCGACGATCCGACCGCGATCGCGCTGATGCTGCTTGGCGGCCACGGCAACATCTCGG
TGACGGCGAACGTCGCACCGCGTGCGATGAGCGATCTGTGCCGCGCGGCGCTGGCCGGCGACGTACAGACGGCTCGCGCG
CTGCACATGAAGCTGCTGTCGCTGCACAAGAACCTGTTCATCGAGGCGAACCCGATTCCGGTGAAGTGGGCGCTGCAGGC
GATGGGCAAGATGCAGGGCGGCATCCGGCTGCCGCTCACGGCGCTCGACGAGCGCTGCCACGAAGCCGTGCGTTCGGCCC
TCGTCGAGGCCGGCGTCCTCGCCTGA

Upstream 100 bases:

>100_bases
CGCGACCCCGAAGGCGGGGGCGGGAATTCCACGTTACGAACTGCCCGGCTAATCCGCTACAATCTCAACGTTTACCGGTA
CATACTCTCAATCGCGTTTC

Downstream 100 bases:

>100_bases
TGCCGAGGCGGCCGCGTCCTGCGGCCGCCGGCTCGAACCCTGATCAACCCGCACCGGCCGGCTCCGTCCGGCGCCGCTCC
TGACGAGCGTTCTAGCAAGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLIDWHIAEGTDALVVVGTSGESATLNVEEHILMIRTAVEHAAKRI
PIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPTQEGMYRHFKTIAEAVDLPVILYNVPGRTVADMANETTLRL
AEVPGIIGVKEATGNIDRAAHLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSDLCRAALAGDVQTARA
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHEAVRSALVEAGVLA

Sequences:

>Translated_301_residues
MANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLIDWHIAEGTDALVVVGTSGESATLNVEEHILMIRTAVEHAAKRI
PIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPTQEGMYRHFKTIAEAVDLPVILYNVPGRTVADMANETTLRL
AEVPGIIGVKEATGNIDRAAHLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSDLCRAALAGDVQTARA
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHEAVRSALVEAGVLA
>Mature_300_residues
ANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLIDWHIAEGTDALVVVGTSGESATLNVEEHILMIRTAVEHAAKRIP
IIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPTQEGMYRHFKTIAEAVDLPVILYNVPGRTVADMANETTLRLA
EVPGIIGVKEATGNIDRAAHLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSDLCRAALAGDVQTARAL
HMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHEAVRSALVEAGVLA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=305, Percent_Identity=26.2295081967213, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13540533, Length=236, Percent_Identity=25.8474576271186, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1788823, Length=289, Percent_Identity=51.5570934256055, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI87082415, Length=300, Percent_Identity=33.6666666666667, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1786463, Length=243, Percent_Identity=37.8600823045267, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789620, Length=233, Percent_Identity=29.1845493562232, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31869; Mature: 31738

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLIDWHIAEGTDALVVVGTSGESATL
CCCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
NVEEHILMIRTAVEHAAKRIPIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPT
EHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QEGMYRHFKTIAEAVDLPVILYNVPGRTVADMANETTLRLAEVPGIIGVKEATGNIDRAA
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCEEEEECCCCCEEEECCCCCHHHHH
HLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSDLCRAALAGDVQTARA
HHHHCCCCCEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHH
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHEAVRSALVEAGVL
HHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
A
C
>Mature Secondary Structure 
ANGTQDGIQIRGSIPAIVTPMLEDGSLDLPAFRKLIDWHIAEGTDALVVVGTSGESATL
CCCCCCCEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
NVEEHILMIRTAVEHAAKRIPIIAGAGGNSTAEAIELTKHAKAVGADATLQVVPYYNKPT
EHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QEGMYRHFKTIAEAVDLPVILYNVPGRTVADMANETTLRLAEVPGIIGVKEATGNIDRAA
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCEEEEECCCCCEEEECCCCCHHHHH
HLIKAAPKHFAIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSDLCRAALAGDVQTARA
HHHHCCCCCEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHH
LHMKLLSLHKNLFIEANPIPVKWALQAMGKMQGGIRLPLTALDERCHEAVRSALVEAGVL
HHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]