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The map label for this gene is aceA [H]

Identifier: 78066826

GI number: 78066826

Start: 2417056

End: 2418363

Strand: Direct

Name: aceA [H]

Synonym: Bcep18194_A5357

Alternate gene names: 78066826

Gene position: 2417056-2418363 (Clockwise)

Preceding gene: 78066825

Following gene: 78066829

Centisome position: 65.43

GC content: 63.46

Gene sequence:

>1308_bases
ATGTCGCGTCAGCAACAGGCACAGGAACTGCAACAGCAATGGGAATCCGATCCGCGCTGGAAAGGCATCAAGCGCAGCTA
CACAGCTGAGGACGTGGTCCGCCTGCGTGGTTCGATCCCGATCGAGCACACGCTCGCCAAGCGCGGTGCGGAAAAGCTGT
GGAGCCTTGTCAACAACGAGCCGTTCGTCAACGCACTCGGTGCACTGACCGGCAACCAGGCGATGCAGCAGGTGAAGGCC
GGCCTCAAGGCCATCTACCTGTCCGGCTGGCAAGTGGCCGGCGACGCGAACGTCGCGGGCGAAATGTACCCGGACCAGTC
GCTCTACCCGGCAAACTCGGTGCCGCTCGTCGTGAAGCGCATCAACAACACGCTGACGCGCGCCGACCAGATCCAGTGGT
CGGAAGGCAAGAACCCGGGCGACGAAGGCTACGTCGATTTCTTCGCACCGATCGTCGCTGACGCGGAAGCCGGTTTCGGC
GGCGTGCTGAACGCATTCGAACTGATGAAGGCGATGATCGAATCCGGCGCATCGGGCGTCCACTTCGAGGACCAGCTCGC
GTCGGTGAAGAAGTGCGGCCACATGGGCGGCAAGGTGCTCGTGCCGACGCGTGAAGCGGTCGCGAAGCTGTCGGCTGCAC
GTCTCGCGGCCGACGTGATGGGCACGTCGACCCTGCTGGTCGCCCGCACCGACGCGGAAGCAGCCGACCTGATCACGTCC
GACGTCGACGACAACGACAAGCCGTTCCTGACGGGCGAGCGCACGGTCGAAGGCTTCTTCCGCACGAAGCCGGGCATCGA
GCAGGCGATCTCGCGCGGTCTCGCGTACGCGCCGTACGCCGACCTCGTCTGGTGCGAAACGGGCAAGCCGGATCTCGAGT
ACGCGAAGAAATTCGCGGAAGCGATCCACAAGCAGTTCCCGGGCAAGATGCTGTCGTACAACTGCTCGCCGTCGTTCAAC
TGGAAGAAGAACCTCGACGACGCGACGATCGCGAAGTTCCAGAAGGAACTCGGCGCGATGGGCTACAAGTTCCAGTTCAT
CACGCTGGCTGGCTTCCATGCGCTGAACTACTCGATGTTCAACCTCGCGCACGGCTATGCCCGCACGCAGATGAGCGCGT
TCGTCGAACTGCAGCAGGCCGAATTCGCGGCAGCGGACAAGGGCTTCACGGCCGTCAAGCACCAGCGCGAAGTCGGCACC
GGCTACTTCGACGCCGTGACGCAGACGGTCGAGCGCGAAGCATCGACGACCGCGCTGCACGGCTCGACCGAAGATGAGCA
GTTCTTCGACGGCAAGAAGGTCGCGTAA

Upstream 100 bases:

>100_bases
AGACCTCACGAACCGGAATCCACCGCTCCCGGCTTCGAGAACAGCGTCACCACCGTCAGATTCAATCCATCAGGCATCGC
ACCGCATCAAGGAGCTCATC

Downstream 100 bases:

>100_bases
GCAGAACAGCACGACGCGCCACGCGTCATGCCGATGCCCGCCCCGCCTCGCGACGGCGCGGCATCGGCCACCGGACAACA
ATCAGGGAGGAGACGGCAGG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSRQQQAQELQQQWESDPRWKGIKRSYTAEDVVRLRGSIPIEHTLAKRGAEKLWSLVNNEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFG
GVLNAFELMKAMIESGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTSTLLVARTDAEAADLITS
DVDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGKKVA

Sequences:

>Translated_435_residues
MSRQQQAQELQQQWESDPRWKGIKRSYTAEDVVRLRGSIPIEHTLAKRGAEKLWSLVNNEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFG
GVLNAFELMKAMIESGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTSTLLVARTDAEAADLITS
DVDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFN
WKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGT
GYFDAVTQTVEREASTTALHGSTEDEQFFDGKKVA
>Mature_434_residues
SRQQQAQELQQQWESDPRWKGIKRSYTAEDVVRLRGSIPIEHTLAKRGAEKLWSLVNNEPFVNALGALTGNQAMQQVKAG
LKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKRINNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFGG
VLNAFELMKAMIESGASGVHFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTSTLLVARTDAEAADLITSD
VDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAEAIHKQFPGKMLSYNCSPSFNW
KKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMFNLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTG
YFDAVTQTVEREASTTALHGSTEDEQFFDGKKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=69.9769053117783, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI1786525, Length=257, Percent_Identity=25.6809338521401, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71982926, Length=432, Percent_Identity=62.5, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17561814, Length=432, Percent_Identity=62.5, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320908, Length=294, Percent_Identity=37.0748299319728, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6325263, Length=256, Percent_Identity=35.15625, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47699; Mature: 47568

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQQQAQELQQQWESDPRWKGIKRSYTAEDVVRLRGSIPIEHTLAKRGAEKLWSLVNNE
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFGGVLNAFELMKAMIESGASGV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTSTLLVARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHC
DVDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKMLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
NLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGKKVA
CCCCCHHHCCCCCCC
>Mature Secondary Structure 
SRQQQAQELQQQWESDPRWKGIKRSYTAEDVVRLRGSIPIEHTLAKRGAEKLWSLVNNE
CHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANVAGEMYPDQSLYPANSVPLVVKR
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHH
INNTLTRADQIQWSEGKNPGDEGYVDFFAPIVADAEAGFGGVLNAFELMKAMIESGASGV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
HFEDQLASVKKCGHMGGKVLVPTREAVAKLSAARLAADVMGTSTLLVARTDAEAADLITS
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHC
DVDDNDKPFLTGERTVEGFFRTKPGIEQAISRGLAYAPYADLVWCETGKPDLEYAKKFAE
CCCCCCCCEECCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHH
AIHKQFPGKMLSYNCSPSFNWKKNLDDATIAKFQKELGAMGYKFQFITLAGFHALNYSMF
HHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
NLAHGYARTQMSAFVELQQAEFAAADKGFTAVKHQREVGTGYFDAVTQTVEREASTTALH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEC
GSTEDEQFFDGKKVA
CCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]