Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 78066796

GI number: 78066796

Start: 2379460

End: 2380173

Strand: Reverse

Name: pyrH

Synonym: Bcep18194_A5327

Alternate gene names: 78066796

Gene position: 2380173-2379460 (Counterclockwise)

Preceding gene: 78066797

Following gene: 78066795

Centisome position: 64.43

GC content: 64.29

Gene sequence:

>714_bases
ATGTCCAATGCCTATAAACGCGTCCTTCTCAAACTCTCCGGCGAAGCGCTGATGGGCGACGATGCCTTCGGCATCAATCG
CGCGACGATCGAACGGATGGTGGCCGATATCGCCGAAGTCGTGCGTCTCGGTACGCAGCTCGCGGTCGTGATCGGTGGCG
GTAATATTTTCCGCGGTGTCGCAGGTGGCGCGGCCGGCATGGATCGCGCAACTGCAGACTACATGGGGATGCTCGCGACG
ATGATGAACGCGCTGGCGCTGCAGGACGCGATGCGCCACGCCGGCATCGAGGCGCGTGTGCAGTCCGCGCTGCGGATGGA
CCAGGTCGTCGAGCCGTACATCCGGCCCCGCGCGATCCGTCAGCTCGAGGAAGGCCGCGTCGTGATCTTCGCGGCCGGTA
CGGGCAACCCGTTCTTCACGACGGACACGGCCGCCGCGCTGCGCGGTTCGGAAGTGGGCGCCGAGGTCGTATTGAAGGCG
ACCAAGGTCGATGGCGTATATTCTGCCGATCCGAAGAAGGATCCGTCGGCCACGCGCTACACGACGATCACGTTCGACGA
GGCGATCAGCCGCAACCTGCAGGTGATGGACGCGACGGCCTTTGCGCTGTGCCGCGACCAGAAGCTGCCGATTCGCGTGT
TTTCGATCAACAAGCCGGGCGCGCTCAAGCGCATCGTGCTGGGCGAGGACGAAGGTACGCTCGTCCACGTGTAA

Upstream 100 bases:

>100_bases
GGCCGGCCGGGAAACCCGGTCCGACCGTCGGCGCTTGCCCGAATCAGTATTTCGCCCCTACAGTTCGTGGTTGTCATCCT
CTCGTCGCTCGGAAGCCCCT

Downstream 100 bases:

>100_bases
ACTCCCGCGGATGCGGGCCATCGGCCGCGGCGCGCCAGATGCGCCAGGTGGGGTCCGCGTTCTTTGAAGGTTTGAAGGTT
CGGAGGTTGAAATGAGTGTC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLAT
MMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKA
TKVDGVYSADPKKDPSATRYTTITFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV

Sequences:

>Translated_237_residues
MSNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLAT
MMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKA
TKVDGVYSADPKKDPSATRYTTITFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV
>Mature_236_residues
SNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGVAGGAAGMDRATADYMGMLATM
MNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIRQLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKAT
KVDGVYSADPKKDPSATRYTTITFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=58.4415584415584, Blast_Score=284, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25405; Mature: 25274

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGV
CCHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEHHC
AGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRY
HHHCCCEEEEEECCCCCCEECCHHHHHCCCCCCHHHEEEEECCCCEECCCCCCCCCCCEE
TTITFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV
EEEEEHHHHHCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEC
>Mature Secondary Structure 
SNAYKRVLLKLSGEALMGDDAFGINRATIERMVADIAEVVRLGTQLAVVIGGGNIFRGV
CHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEHHC
AGGAAGMDRATADYMGMLATMMNALALQDAMRHAGIEARVQSALRMDQVVEPYIRPRAIR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QLEEGRVVIFAAGTGNPFFTTDTAAALRGSEVGAEVVLKATKVDGVYSADPKKDPSATRY
HHHCCCEEEEEECCCCCCEECCHHHHHCCCCCCHHHEEEEECCCCEECCCCCCCCCCCEE
TTITFDEAISRNLQVMDATAFALCRDQKLPIRVFSINKPGALKRIVLGEDEGTLVHV
EEEEEHHHHHCCCEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA