Click here to switch to the map view.

The map label for this gene is guaA

Identifier: 78066768

GI number: 78066768

Start: 2350686

End: 2352305

Strand: Reverse

Name: guaA

Synonym: Bcep18194_A5299

Alternate gene names: 78066768

Gene position: 2352305-2350686 (Counterclockwise)

Preceding gene: 78066769

Following gene: 78066767

Centisome position: 63.68

GC content: 65.68

Gene sequence:

>1620_bases
ATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACCCAACTGATTGCGCGACGCGTGCGCGAAGCGCACGT
CTACTGCGAAATCCATCCGAACGATGTGTCCGACGACTTCGTCCGCGAGTTCGCGCCGAAGGCGGTGATCCTGTCGGGCA
GCCACGCGAGCACGTACGAAGACCATCAGCTGCGCGCGCCGCAGGCTGTGTGGGATCTCGGCGTGCCGGTGCTCGGCATC
TGCTACGGCATGCAGACGATGGCCGTGCAGCTCGGCGGCAAGGTCGAGTGGAGCGACCACCGCGAATTCGGTTACGCGGA
AATGCGCGCGCACGGCCATACGCGCCTGCTCGACGGCATCGAGGACTTCAAGACGGACGAAGGCCACGGGATGCTGAAGG
TCTGGATGAGCCACGGCGACAAGGTTGCCGAGCTGCCGCCGGGCTTCGCGCTGATGGCGTCGACGCCGAGCTGCCCGATC
GCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCATCCGGAAGTCACGCACACGCTGAAGGGCCGCCA
GATCATCGAGCGCTTCGTGCTGCAGATCGCAGGCGCGAAGCCCGACTGGATCATGAAGAACCACATCGAGGAAGCCGTCG
CGAAGATCCGCGAGCAGGTCGGTGACGAGGAAGTGATTCTCGGCCTGTCGGGCGGTGTCGATTCGAGCGTCGCCGCTGCG
CTGATCCATCGCGCGATCGGTGACCAGCTCACCTGCGTGTTCGTCGACCACGGCCTGCTGCGCCTGAACGAAGGCAAGAT
GGTGCTCGACATGTTCGAGGGCCGCCTGCATGCGAAGGTCGTGCACGTCGACGCATCCGAACAGTTCCTCGGCCACCTGG
CGGGCGTGACCGATCCGGAAGCGAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAGGTGTTCCAGGCCGAGGCGCAGAAG
CTGTCGAAGGCGAAGTGGCTCGCGCAGGGCACGATCTATCCGGACGTGGTCGAATCGGGCGGCACGAAGACGAAGAAGGC
AACGACGATCAAGAGCCACCACAACGTCGGCGGCCTGCCGGAAACGCTCGGGCTCAAGCTGCTCGAGCCGCTGCGCGACC
TGTTCAAGGACGAAGTGCGCGAGCTGGGCGTCGCGCTCGGCCTGCCGCCGGAGATGGTGTACCGCCATCCGTTCCCGGGC
CCGGGCCTCGGCGTGCGGATTCTCGGCGAAGTGAAGCGCGAGTTCGCGGATCTGCTGCGCCGCGCGGACGCGATCTTCAT
CGAGGAACTGCGCAACACGACCGCGACCGCGCACGATGCGGCTGCCGGCCTGTGCGGCGAAGCCGATGTCGGCAAGAGCT
GGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTCAAGTCGGTGGGCGTGATGGGCGATGGCCGCACGTAC
GACTACGTGACGTCGTTGCGCGCCGTGCAGACGACCGACTTCATGACCGCACACTGGGCGCATCTGCCGTACGCGCTGCT
CGGCCGCGCGTCGAACCGGATCATCAACGAGGTGCGCGGGATCAACCGAGTGGTGTATGACATCTCGGGCAAGCCGCCGG
CGACGATCGAGTGGGAGTAA

Upstream 100 bases:

>100_bases
CGTGCTGCCTTCCGCCCGACGCCGTTGTCCATGCTATTGACGCAGCGCATGATGCAAATGATGCGCTGCTTTTCTTATTC
TCTTCATCCCGTCCGCAGCC

Downstream 100 bases:

>100_bases
TTCGGCGTCCGGCACGTGCCGGTACGACCTGACAGCAGAACACATCAAAGCCCGCTTCACAGCGGGCTTTTTTGTTTTTG
GCAGGATTGGAGCATTACGC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGIEDFKTDEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTLKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAQK
LSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREFADLLRRADAIFIEELRNTTATAHDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGIEDFKTDEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTLKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAQK
LSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREFADLLRRADAIFIEELRNTTATAHDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE
>Mature_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGIEDFKTDEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTLKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAQK
LSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREFADLLRRADAIFIEELRNTTATAHDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=561, Percent_Identity=34.0463458110517, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=63.9925373134328, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=582, Percent_Identity=34.020618556701, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71992717, Length=582, Percent_Identity=34.020618556701, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71992710, Length=582, Percent_Identity=34.020618556701, Blast_Score=277, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=47.4452554744526, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=34.2857142857143, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59469; Mature: 59469

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHHH
EDFKTDEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCHHH
HTLKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAQKLSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREFADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRNTTATAHDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEECC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCHHHHHHH
EDFKTDEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCHHH
HTLKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAQKLSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREFADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRNTTATAHDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA