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The map label for this gene is glxR [H]

Identifier: 78066760

GI number: 78066760

Start: 2345393

End: 2346277

Strand: Direct

Name: glxR [H]

Synonym: Bcep18194_A5291

Alternate gene names: 78066760

Gene position: 2345393-2346277 (Clockwise)

Preceding gene: 78066759

Following gene: 78066761

Centisome position: 63.49

GC content: 69.6

Gene sequence:

>885_bases
ATGCAAACCGCAGTCGGATTCATCGGCCTCGGCGTGATGGGCACGCCGATGGCGCTCAATCTTGCGCGGGCCGGCACGCC
GCTCGTCGTGTGGAGCCGGTCGCACGGCAGCGACGATGCACTGCGCGACGCCGGCGCGCGCGTGGCCGAGCACATCGACG
ACGTGTTCGCGAGCTGCCGCACCGTGATCCTGATGCTCGCGAACGACGCGGCGATCGACGCCGCCCTCGCGCGCGGCACG
CCCGGTTTCGCCGCCCGTGTCGGCGGGCACACCATCGTGAACATGGGCACGAACGCCCCCGAGTATTCGCGCGCGCTGGC
CGATGACATCGCTGCCGCGTCGGGCCGTTACGTCGAAGCGCCCGTGTCGGGGTCGCGCAAGCCGGCCGAAGCCGGGCAAC
TCGTCGTGATGCTCGCCGGCGCACCGGACGACGTCGACGCCGTCCGCGCGCTCGTGAAGCCGCTGTGCCGCGACAGCTTC
GTGTGCGGCGACGTCCCGTCGGCGCTGACGATGAAGCTCGCCGTGAACCTGTTCCTGATCACGATGGTCACCGGCCTGAC
CGAAGCCACGCATTTCGCGCAACGCCACGGCATCGATCTCGCCCGTTTCGCCGACGTGCTGAACGCGGGCCCGATGGCGA
GCGACGTGTCGCGTGTGAAGCTCGGCAAACTCGTCACCGCGGATTTTTCCGTGCAGGCCGCGATCACCGACGTGCTGAAA
AATGCACGCCTCGTCGCCGAAGCCGCGCGCGGCATCGGCATCGCGTCACCGCTGCTCGACATCTGCCATGCGCTGTACGG
CGAGACCGAGCGGGCCGGACATGGCGCGGACGACATGGTCGCCGTGATCCGCGCGATCGAGCAGCGCACCGACGACGCGC
GATGA

Upstream 100 bases:

>100_bases
TGACGTGGCGCGCGCGGGTGCGCGGACGAAATAGCGGGCGTGCAGAAACGCTGCGATACTGACGCCCACGATCGTCTCCA
CCCACCGTGGGAGCCAGAAC

Downstream 100 bases:

>100_bases
ATCGTCGCCGGCCATCCCACTCACTCGAACGCACCCGCGCGTAGATCCATCATGTCCGATTCGCCCCGCCCACCGACCGA
CGTCACCGCTTCCGTCCGCC

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MQTAVGFIGLGVMGTPMALNLARAGTPLVVWSRSHGSDDALRDAGARVAEHIDDVFASCRTVILMLANDAAIDAALARGT
PGFAARVGGHTIVNMGTNAPEYSRALADDIAAASGRYVEAPVSGSRKPAEAGQLVVMLAGAPDDVDAVRALVKPLCRDSF
VCGDVPSALTMKLAVNLFLITMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVTADFSVQAAITDVLK
NARLVAEAARGIGIASPLLDICHALYGETERAGHGADDMVAVIRAIEQRTDDAR

Sequences:

>Translated_294_residues
MQTAVGFIGLGVMGTPMALNLARAGTPLVVWSRSHGSDDALRDAGARVAEHIDDVFASCRTVILMLANDAAIDAALARGT
PGFAARVGGHTIVNMGTNAPEYSRALADDIAAASGRYVEAPVSGSRKPAEAGQLVVMLAGAPDDVDAVRALVKPLCRDSF
VCGDVPSALTMKLAVNLFLITMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVTADFSVQAAITDVLK
NARLVAEAARGIGIASPLLDICHALYGETERAGHGADDMVAVIRAIEQRTDDAR
>Mature_294_residues
MQTAVGFIGLGVMGTPMALNLARAGTPLVVWSRSHGSDDALRDAGARVAEHIDDVFASCRTVILMLANDAAIDAALARGT
PGFAARVGGHTIVNMGTNAPEYSRALADDIAAASGRYVEAPVSGSRKPAEAGQLVVMLAGAPDDVDAVRALVKPLCRDSF
VCGDVPSALTMKLAVNLFLITMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVTADFSVQAAITDVLK
NARLVAEAARGIGIASPLLDICHALYGETERAGHGADDMVAVIRAIEQRTDDAR

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=27.6223776223776, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI23308751, Length=209, Percent_Identity=32.0574162679426, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=27.9151943462898, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693186, Length=255, Percent_Identity=27.843137254902, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=26.7605633802817, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=29.0102389078498, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=29.0102389078498, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30567; Mature: 30567

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTAVGFIGLGVMGTPMALNLARAGTPLVVWSRSHGSDDALRDAGARVAEHIDDVFASCR
CCCCHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
TVILMLANDAAIDAALARGTPGFAARVGGHTIVNMGTNAPEYSRALADDIAAASGRYVEA
HHHHHHCCCHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEC
PVSGSRKPAEAGQLVVMLAGAPDDVDAVRALVKPLCRDSFVCGDVPSALTMKLAVNLFLI
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
TMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVTADFSVQAAITDVLK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHH
NARLVAEAARGIGIASPLLDICHALYGETERAGHGADDMVAVIRAIEQRTDDAR
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQTAVGFIGLGVMGTPMALNLARAGTPLVVWSRSHGSDDALRDAGARVAEHIDDVFASCR
CCCCHHHHHHCCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
TVILMLANDAAIDAALARGTPGFAARVGGHTIVNMGTNAPEYSRALADDIAAASGRYVEA
HHHHHHCCCHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEC
PVSGSRKPAEAGQLVVMLAGAPDDVDAVRALVKPLCRDSFVCGDVPSALTMKLAVNLFLI
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
TMVTGLTEATHFAQRHGIDLARFADVLNAGPMASDVSRVKLGKLVTADFSVQAAITDVLK
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHH
NARLVAEAARGIGIASPLLDICHALYGETERAGHGADDMVAVIRAIEQRTDDAR
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]