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The map label for this gene is envZ [H]

Identifier: 78066719

GI number: 78066719

Start: 2303497

End: 2304858

Strand: Direct

Name: envZ [H]

Synonym: Bcep18194_A5250

Alternate gene names: 78066719

Gene position: 2303497-2304858 (Clockwise)

Preceding gene: 78066718

Following gene: 78066720

Centisome position: 62.36

GC content: 67.55

Gene sequence:

>1362_bases
ATGCGTATCGACCGGCGCCTCCTGCAGCTCGCGTTCGGCGGGCTGTTCTGGCGCACCTTCCTGCTGATCGCGCTGCTGAT
CTCGGTCAGTCTCGCCGCGTGGTTCCAGAGCTTTCGCGTGATCGAGCGCGAGCCGCGTGCGCAGCGCGTCGCGCTGCAGC
TCGTCGCGATCGTGAAGCTCACGCGCACCGCCCTGCTCTATTCCGATCCCGATCTGCGGCGCGCGCTGCTTCAGGATCTC
GAGAGCAACGAGGGCGTGCGCGTTTACCCGCGCGAGAAAACCGACAAGTTCAAGCTGCAGCCCGACGAATCGCTGAACCG
TCTGATCGAACACGACATCCGCAGCCGCCTCGGCGACGATACCGTGATCGCACAGTCGGTCAACGACATTCCCGGCGTAT
GGATCAGCTTCAAGATCGACGACGACGATTACTGGGTCGCGCTCGACCGCGACCAGCTCGACAACGTCACGGGCCTGCAG
TGGGCCGGCTGGGGGCTGTTCGCGCTCGCATTGTCGCTATTCGGCTCCGCGTTCATCACAAGCCTCGTGAACCGGCCGTT
CTCGCGGCTCGCGCTCGCCGCGCGCCAGGTCGGTTCGGGCCAGGCGCCCGACCCGCTGCCCGAGCGCGGGATGGGCGTCG
CGGCCGACACCAACCGCAGCTTCAACCAGATGGTGCGCGACCTCGAGCAGCTCGAGGCCGACCGTGCGCTGATGCTCGCG
GGCATCTCGCACGACCTGCGCACGCCACTCGCGCGGCTACGGCTCGAAACCGAGATGAGCCCGTCCGACCAGGCGACCAA
GGATGCAATGGTCGACGACATCGAGCAGATGGACCGCATCATTGCGGCCTTCATCGACTACGCGCGCCCGTCGCAACGCA
AACCGGAGCCCGTCGACCTGTCGTCGATCGCGCAGGAAGTCGCCGCACGCTTGTCGGGCGAGGATGGCGTCGAGATCCGC
ACGCGGCTCGCGCCGAGCGCGATCATCGAAGCCGACGAGACCGACATGCGCCGCGTGATCGGCAACCTCGTCGAGAACGC
GCGCAAGTACGGGCAAAGCAAGCAGGACGGCGTGTCGCGCATCACGCTCGAGACACGTGTGTCGCACGCACGCGTCGAGC
TGTCGGTGAGCGACGAAGGCCCCGGCATCCCCGAGGATCAACTACCGCTGGTGATGCGGCCGTTCTACCGCGTCGACACC
GCCCGCACCAAGGCGGACGGCACGGGCCTCGGGATGGCGATCGTGCTGCGTCTCGTCGGCCGTTATCGCGGCGCGCTGCG
CCTGCGCAACCGCAACCCCGAAGCGGGCCTCGAAGTCACGCTCGAATTCCCCGGCGCCGGCAAGGCGCGTGCGACTGCGT
GA

Upstream 100 bases:

>100_bases
CGTTTCATCCAGACCGTCTGGGGCCTCGGCTACGTGTTCATCCCGGACGGCGCCGCCTGATCTTTTTTCTTTCCGGTTTC
GCCCGCCCACGGCCCGTCCC

Downstream 100 bases:

>100_bases
CGCGCTCGCGCACGCTTCTTGCACTGCACACTATCGATCCGGTTGAAAAAAGCTATGAAGGTCGTTAGTCAAAATCTATT
GAAGTGACTAACTAATAGTG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDNVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQVGSGQAPDPLPERGMGVAADTNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDLSSIAQEVAARLSGEDGVEIR
TRLAPSAIIEADETDMRRVIGNLVENARKYGQSKQDGVSRITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDT
ARTKADGTGLGMAIVLRLVGRYRGALRLRNRNPEAGLEVTLEFPGAGKARATA

Sequences:

>Translated_453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDNVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQVGSGQAPDPLPERGMGVAADTNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDLSSIAQEVAARLSGEDGVEIR
TRLAPSAIIEADETDMRRVIGNLVENARKYGQSKQDGVSRITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDT
ARTKADGTGLGMAIVLRLVGRYRGALRLRNRNPEAGLEVTLEFPGAGKARATA
>Mature_453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDNVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQVGSGQAPDPLPERGMGVAADTNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDLSSIAQEVAARLSGEDGVEIR
TRLAPSAIIEADETDMRRVIGNLVENARKYGQSKQDGVSRITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDT
ARTKADGTGLGMAIVLRLVGRYRGALRLRNRNPEAGLEVTLEFPGAGKARATA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=425, Percent_Identity=33.1764705882353, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1787894, Length=208, Percent_Identity=34.6153846153846, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=27.9411764705882, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=28.4697508896797, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=27.3684210526316, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=28.8990825688073, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=29.1479820627803, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=27.0642201834862, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=26.4227642276423, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=319, Percent_Identity=24.7648902821317, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=216, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=29.1139240506329, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=213, Percent_Identity=28.169014084507, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=25.9786476868327, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=233, Percent_Identity=27.4678111587983, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50568; Mature: 50568

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDD
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCCC
TVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDNVTGLQWAGWGLFALALSLFGSAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SLVNRPFSRLALAARQVGSGQAPDPLPERGMGVAADTNRSFNQMVRDLEQLEADRALMLA
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCHHHHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
SSIAQEVAARLSGEDGVEIRTRLAPSAIIEADETDMRRVIGNLVENARKYGQSKQDGVSR
HHHHHHHHHHHCCCCCCEEHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHE
ITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDTARTKADGTGLGMAIVLRLVG
EEHHHHHCEEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RYRGALRLRNRNPEAGLEVTLEFPGAGKARATA
HHHHHEEECCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPREKTDKFKLQPDESLNRLIEHDIRSRLGDD
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHHHHCCCC
TVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDNVTGLQWAGWGLFALALSLFGSAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SLVNRPFSRLALAARQVGSGQAPDPLPERGMGVAADTNRSFNQMVRDLEQLEADRALMLA
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCHHHHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPSQRKPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
SSIAQEVAARLSGEDGVEIRTRLAPSAIIEADETDMRRVIGNLVENARKYGQSKQDGVSR
HHHHHHHHHHHCCCCCCEEHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHE
ITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDTARTKADGTGLGMAIVLRLVG
EEHHHHHCEEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RYRGALRLRNRNPEAGLEVTLEFPGAGKARATA
HHHHHEEECCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]