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The map label for this gene is kbl [C]

Identifier: 78066462

GI number: 78066462

Start: 2023163

End: 2024386

Strand: Reverse

Name: kbl [C]

Synonym: Bcep18194_A4993

Alternate gene names: 78066462

Gene position: 2024386-2023163 (Counterclockwise)

Preceding gene: 78066463

Following gene: 78066461

Centisome position: 54.8

GC content: 59.8

Gene sequence:

>1224_bases
ATGACGTTGAATATCTTTGACGGCTCCACCCGGGTTCGGGCGCTCAATAAACTGAACGAATGGTTGACACAAAGCGGCAA
CAAGCAGGTCTGGAGCCGGGTGTGTTCCGGCGTGCCGGGCAGGACAGTGACTGCACGGCTCTCGCATGGCGATCATCCGG
ATGTGCCGCAGATTCATTTCGGCTCCTATAACTACTCGGGGCTGAACGACCGGCATGAAGTCGTTGATGCCGCACGCGAG
GCGCTGGATCGTCACGGTGCGACGACCAGCGGGGTGCGGATCCTGAACGGAACTACCGCGTTGCATCTCGATCTGGAAAA
CGCGCTGGCGGCGTTTACGCGCTTCGAATCGTGCGTAACGTACTCAAGCGCATATGTAGCGAATCTCGCCGTGATCTCGA
CACTGGCAGGCGAAACGGACGTTATTTACAGCGACGAGCTCAATCACGCATCGATCGCTGACGGTATTCGGCTGTCGCGG
GCGAAGCAGGTGAAGTATTCGCACAAGGACGTTGCACAGCTCGAAGGGTTGTTGCGATCCGCGCCGCTCTCGGATCGCAA
GTTCATCATTACCGATGGCGTATTCAGCATGGACGGCGACTTTGCGCCGTTGCCGCAGATTGTCGAGCTGGCAAAGAGAT
ATCGCGCGTTCGTTATCGTCGACGACGCCCACGGGACGGCGTCCTGCGGGCCGAACGGACGAGGAACCTTGGCGCACTTC
GGACTCGAGAAGGAGGTGGACGTCCTGATCGGCAGTTTGAGCAAAGGACTGCCGGGAGTGGGCGGGTTTGCGTGTGCCAG
CGAGGAAATCGGCGAACTGCTTCGCTACGGCTCCAACGGCTACATTTTCTCGGCGTCCATTCCGCCTTCGGTTGCCGGTG
GCTTGATCAAGGCGGTCGAAATACTCGAAAGCGAACCCGACATCCAGGTGCGGCTGCACAGGAACGAGCGGCAGATTCGC
GACGGATTGCGGGAAGTCGGCTTCGACGTGATGCATAGCGAGACGCCGATCATCCCGCTCGCGATGCCTGATCGGGCGAC
CGCCTTCAATTTCGCGCGCGGCATGCATGAGCGCGGCGTCTTCGTTAATCCGATCTGTTACCCGGCGGTTGCGATGAATC
GCGCCCGCATCCGCGTCAACGCCAGCGCGTCGCTGACGGAATCGGATATCTCGAGCGCGCTTGTCACTTTCGCGGAAGTG
GGACGGAGCATTGGCCTTCTATGA

Upstream 100 bases:

>100_bases
TTGGCGTCGAGATAGATGAGGAGCAGGTGGGACGGCTGAAAAGCATCGGAAGAATTGCTGACCGCATTACCAATGAGGCG
AACGCGAACGGGGAAGTCGA

Downstream 100 bases:

>100_bases
GTTCCGCGAGCCCCCTCATCGAACTGAAAGCGAATGAGGCACAGTGCCTGCACACGGATTTGGGCTGGCACGATGCGCTC
CTCGCTGCTTACGCGGAATT

Product: glycine C-acetyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTLNIFDGSTRVRALNKLNEWLTQSGNKQVWSRVCSGVPGRTVTARLSHGDHPDVPQIHFGSYNYSGLNDRHEVVDAARE
ALDRHGATTSGVRILNGTTALHLDLENALAAFTRFESCVTYSSAYVANLAVISTLAGETDVIYSDELNHASIADGIRLSR
AKQVKYSHKDVAQLEGLLRSAPLSDRKFIITDGVFSMDGDFAPLPQIVELAKRYRAFVIVDDAHGTASCGPNGRGTLAHF
GLEKEVDVLIGSLSKGLPGVGGFACASEEIGELLRYGSNGYIFSASIPPSVAGGLIKAVEILESEPDIQVRLHRNERQIR
DGLREVGFDVMHSETPIIPLAMPDRATAFNFARGMHERGVFVNPICYPAVAMNRARIRVNASASLTESDISSALVTFAEV
GRSIGLL

Sequences:

>Translated_407_residues
MTLNIFDGSTRVRALNKLNEWLTQSGNKQVWSRVCSGVPGRTVTARLSHGDHPDVPQIHFGSYNYSGLNDRHEVVDAARE
ALDRHGATTSGVRILNGTTALHLDLENALAAFTRFESCVTYSSAYVANLAVISTLAGETDVIYSDELNHASIADGIRLSR
AKQVKYSHKDVAQLEGLLRSAPLSDRKFIITDGVFSMDGDFAPLPQIVELAKRYRAFVIVDDAHGTASCGPNGRGTLAHF
GLEKEVDVLIGSLSKGLPGVGGFACASEEIGELLRYGSNGYIFSASIPPSVAGGLIKAVEILESEPDIQVRLHRNERQIR
DGLREVGFDVMHSETPIIPLAMPDRATAFNFARGMHERGVFVNPICYPAVAMNRARIRVNASASLTESDISSALVTFAEV
GRSIGLL
>Mature_406_residues
TLNIFDGSTRVRALNKLNEWLTQSGNKQVWSRVCSGVPGRTVTARLSHGDHPDVPQIHFGSYNYSGLNDRHEVVDAAREA
LDRHGATTSGVRILNGTTALHLDLENALAAFTRFESCVTYSSAYVANLAVISTLAGETDVIYSDELNHASIADGIRLSRA
KQVKYSHKDVAQLEGLLRSAPLSDRKFIITDGVFSMDGDFAPLPQIVELAKRYRAFVIVDDAHGTASCGPNGRGTLAHFG
LEKEVDVLIGSLSKGLPGVGGFACASEEIGELLRYGSNGYIFSASIPPSVAGGLIKAVEILESEPDIQVRLHRNERQIRD
GLREVGFDVMHSETPIIPLAMPDRATAFNFARGMHERGVFVNPICYPAVAMNRARIRVNASASLTESDISSALVTFAEVG
RSIGLL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=373, Percent_Identity=38.6058981233244, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI284448556, Length=351, Percent_Identity=39.3162393162393, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=32.1621621621622, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4758668, Length=399, Percent_Identity=31.077694235589, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI83977444, Length=351, Percent_Identity=30.1994301994302, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI83977442, Length=351, Percent_Identity=30.1994301994302, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI83977440, Length=351, Percent_Identity=30.1994301994302, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4502025, Length=351, Percent_Identity=31.3390313390313, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI40316939, Length=351, Percent_Identity=31.3390313390313, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI5454084, Length=380, Percent_Identity=28.6842105263158, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1790046, Length=353, Percent_Identity=38.5269121813031, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=31.2138728323699, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994529, Length=357, Percent_Identity=38.0952380952381, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI32566772, Length=403, Percent_Identity=29.2803970223325, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17560914, Length=401, Percent_Identity=28.1795511221945, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=401, Percent_Identity=28.1795511221945, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71982617, Length=260, Percent_Identity=31.1538461538462, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71982625, Length=260, Percent_Identity=31.1538461538462, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320267, Length=404, Percent_Identity=32.4257425742574, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320438, Length=361, Percent_Identity=29.9168975069252, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=277, Percent_Identity=27.0758122743682, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24662918, Length=355, Percent_Identity=38.5915492957746, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=30.7042253521127, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17136286, Length=407, Percent_Identity=26.7813267813268, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24653280, Length=374, Percent_Identity=29.144385026738, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24653276, Length=374, Percent_Identity=29.144385026738, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24653278, Length=374, Percent_Identity=29.144385026738, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 44004; Mature: 43873

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNIFDGSTRVRALNKLNEWLTQSGNKQVWSRVCSGVPGRTVTARLSHGDHPDVPQIHF
CEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEE
GSYNYSGLNDRHEVVDAAREALDRHGATTSGVRILNGTTALHLDLENALAAFTRFESCVT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHHHH
YSSAYVANLAVISTLAGETDVIYSDELNHASIADGIRLSRAKQVKYSHKDVAQLEGLLRS
HHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHCCHHHHHHHHHHCCHHHHHHHHHHHHH
APLSDRKFIITDGVFSMDGDFAPLPQIVELAKRYRAFVIVDDAHGTASCGPNGRGTLAHF
CCCCCCEEEEECCEEECCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCEEEC
GLEKEVDVLIGSLSKGLPGVGGFACASEEIGELLRYGSNGYIFSASIPPSVAGGLIKAVE
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHH
ILESEPDIQVRLHRNERQIRDGLREVGFDVMHSETPIIPLAMPDRATAFNFARGMHERGV
HHCCCCCEEEEEECCHHHHHHHHHHHCCHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC
FVNPICYPAVAMNRARIRVNASASLTESDISSALVTFAEVGRSIGLL
EECCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLNIFDGSTRVRALNKLNEWLTQSGNKQVWSRVCSGVPGRTVTARLSHGDHPDVPQIHF
EEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEE
GSYNYSGLNDRHEVVDAAREALDRHGATTSGVRILNGTTALHLDLENALAAFTRFESCVT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHHHH
YSSAYVANLAVISTLAGETDVIYSDELNHASIADGIRLSRAKQVKYSHKDVAQLEGLLRS
HHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHCCHHHHHHHHHHCCHHHHHHHHHHHHH
APLSDRKFIITDGVFSMDGDFAPLPQIVELAKRYRAFVIVDDAHGTASCGPNGRGTLAHF
CCCCCCEEEEECCEEECCCCCCCHHHHHHHHHHCEEEEEEECCCCCCCCCCCCCCCEEEC
GLEKEVDVLIGSLSKGLPGVGGFACASEEIGELLRYGSNGYIFSASIPPSVAGGLIKAVE
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHH
ILESEPDIQVRLHRNERQIRDGLREVGFDVMHSETPIIPLAMPDRATAFNFARGMHERGV
HHCCCCCEEEEEECCHHHHHHHHHHHCCHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCC
FVNPICYPAVAMNRARIRVNASASLTESDISSALVTFAEVGRSIGLL
EECCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA