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The map label for this gene is cobW [H]

Identifier: 78066275

GI number: 78066275

Start: 1819262

End: 1820350

Strand: Direct

Name: cobW [H]

Synonym: Bcep18194_A4805

Alternate gene names: 78066275

Gene position: 1819262-1820350 (Clockwise)

Preceding gene: 78066268

Following gene: 78066276

Centisome position: 49.25

GC content: 67.4

Gene sequence:

>1089_bases
ATGACCCTTCGCAAGCTTCCCGTCACGATCGTCACGGGCTTTCTCGGCAGCGGCAAGACCACGCTGATGCGCCACATCCT
GCAGCACGCCGAAGGCCGCCGCATCGCGGTGATCGTCAACGAATTCGGCGAGCTCGGCATCGACGGCGAAATCCTCAAGG
GCTGCGGCATCGGCTGCGAGGATGCCGACGGCGCGCAGGGCGAAGCGGCGGGCCAGCTGTACGAACTCGCGAACGGCTGC
CTGTGCTGCACCGTGCAGGAAGAGTTCTATCCGGTGATGGAAGCGCTCGTCGAGCGCCGCGCGGACATCGACCACGTGCT
GATCGAGACGTCCGGCCTCGCGCTGCCGAAGCCGCTCGTGCAGGCGTTCAACTGGCCGACGATCCGCAACAGCTTCACGG
TCGATGCGGTCGTGACCGTGGTCGACGGGCCGGCCGCCGCGAGCGGCCAGTTCGCGGAAAACCCGCAGGCCGTCGACGCG
CAGCGCCGCGCCGATCCGAACCTCGATCACGAATCGCCGCTGCACGAGCTGTTCGCCGATCAACTGTCGTCCGCCGATCT
CGTGATCGTGAACAAGGCCGATCTCGTCGGCGATGCGGAATTCGCGCAGATCGAAACCGCGATCCGCGACGAGATCCCGC
CGCAGGTGAAGATCGTGCGCGCGACGCGCGGCGAGCTCGATCTCGCGATGCTGCTCGGCCTCGAATCGGCATCGGAAGAA
ACGATCCACCTGCGTCACGACCATCACGGCTCGGCCGAGGACGGCGATCACGATCACCATCACGACGATTTCGACTCGGT
GGTCGTATCGGGCGACGCCGGCACGCGCGAAGCGACGATCGCCGCGCTGCAGCGGGTCGTCGAGGCACACACGATCTATC
GCGCGAAAGGCTTCGCCGCGCTGCCCGGCGCGCCGATGCGCCTCGTGATCCAGGGCGTCGGCCGCCGCTTCGACAGCTAT
TTCGACCGTCGCTGGCAGGATGGCGAAACGCGCGCGAGCCGCTTCGTGCTGATCGGCGAGGATCTCGACGCGACCGTGCT
GCAACGCGCGTTCGACGCCGCGTGCGCGGCCGAGCCGCAACAGGCGTAA

Upstream 100 bases:

>100_bases
GGATCGCGCGGCGGCATGCCTGCGATCCGCCAGATGAACTGCCACGCCGCCTTCGACGCGACGATCCCGGCCTGATTCCA
TTTTCGACACAGGACCTACC

Downstream 100 bases:

>100_bases
CGCACGATGCATCTGCTGCGCACCACGCCGGGCGGCTTCGTCGACGATACGCAGGGCGTCGTCCGGATCGACCAGCAGCC
GGCCGACATCGTGATCCTGA

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCEDADGAQGEAAGQLYELANGC
LCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLVQAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDA
QRRADPNLDHESPLHELFADQLSSADLVIVNKADLVGDAEFAQIETAIRDEIPPQVKIVRATRGELDLAMLLGLESASEE
TIHLRHDHHGSAEDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAALPGAPMRLVIQGVGRRFDSY
FDRRWQDGETRASRFVLIGEDLDATVLQRAFDAACAAEPQQA

Sequences:

>Translated_362_residues
MTLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCEDADGAQGEAAGQLYELANGC
LCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLVQAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDA
QRRADPNLDHESPLHELFADQLSSADLVIVNKADLVGDAEFAQIETAIRDEIPPQVKIVRATRGELDLAMLLGLESASEE
TIHLRHDHHGSAEDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAALPGAPMRLVIQGVGRRFDSY
FDRRWQDGETRASRFVLIGEDLDATVLQRAFDAACAAEPQQA
>Mature_361_residues
TLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCEDADGAQGEAAGQLYELANGCL
CCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLVQAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDAQ
RRADPNLDHESPLHELFADQLSSADLVIVNKADLVGDAEFAQIETAIRDEIPPQVKIVRATRGELDLAMLLGLESASEET
IHLRHDHHGSAEDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAALPGAPMRLVIQGVGRRFDSYF
DRRWQDGETRASRFVLIGEDLDATVLQRAFDAACAAEPQQA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=376, Percent_Identity=27.9255319148936, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI33469141, Length=376, Percent_Identity=27.6595744680851, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI148727351, Length=376, Percent_Identity=27.9255319148936, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI146231952, Length=375, Percent_Identity=28.2666666666667, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI223941779, Length=365, Percent_Identity=27.1232876712329, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI223941776, Length=377, Percent_Identity=26.525198938992, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI119120938, Length=153, Percent_Identity=35.9477124183007, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI87082430, Length=362, Percent_Identity=28.7292817679558, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788499, Length=188, Percent_Identity=31.9148936170213, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324356, Length=374, Percent_Identity=27.0053475935829, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39241; Mature: 39110

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCE
CCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCHHHHHCCCCCC
DADGAQGEAAGQLYELANGCLCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLV
CCCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDAQRRADPNLDHESPLHELFAD
HHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCHHHHHHHH
QLSSADLVIVNKADLVGDAEFAQIETAIRDEIPPQVKIVRATRGELDLAMLLGLESASEE
HCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCC
TIHLRHDHHGSAEDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAA
EEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
LPGAPMRLVIQGVGRRFDSYFDRRWQDGETRASRFVLIGEDLDATVLQRAFDAACAAEPQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
QA
CC
>Mature Secondary Structure 
TLRKLPVTIVTGFLGSGKTTLMRHILQHAEGRRIAVIVNEFGELGIDGEILKGCGIGCE
CCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCHHHHHCCCCCC
DADGAQGEAAGQLYELANGCLCCTVQEEFYPVMEALVERRADIDHVLIETSGLALPKPLV
CCCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
QAFNWPTIRNSFTVDAVVTVVDGPAAASGQFAENPQAVDAQRRADPNLDHESPLHELFAD
HHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHCHHHHCCCCCCCCCHHHHHHHH
QLSSADLVIVNKADLVGDAEFAQIETAIRDEIPPQVKIVRATRGELDLAMLLGLESASEE
HCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCC
TIHLRHDHHGSAEDGDHDHHHDDFDSVVVSGDAGTREATIAALQRVVEAHTIYRAKGFAA
EEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
LPGAPMRLVIQGVGRRFDSYFDRRWQDGETRASRFVLIGEDLDATVLQRAFDAACAAEPQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
QA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]