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The map label for this gene is acsA [H]

Identifier: 78065930

GI number: 78065930

Start: 1418004

End: 1419623

Strand: Reverse

Name: acsA [H]

Synonym: Bcep18194_A4459

Alternate gene names: 78065930

Gene position: 1419623-1418004 (Counterclockwise)

Preceding gene: 78065931

Following gene: 78065929

Centisome position: 38.43

GC content: 69.26

Gene sequence:

>1620_bases
ATGCTGCCCGCCGCCGACCGCTACGACGACCTGCTCTCCCGCTTCGCGTGGGGCGTTCCGGCACGCTACAACATTGGCGT
GGATGTCTGCGACAAATGGGCCGACGGCAGCGGACGCCTCGCGCTGATCCACGAAACGGCGCAAGGCGATGTTTTTCGCA
TCACGTTCGACGACTTGAAGAATGCCTCTAACCGGCTCGCGAACAGCTTTGTGCGCGCAGGCCTGAGGCGCGGCGACCGC
ATCGGCATCTTTCTCGCGCAGGGCCCCGAAACGGCCATCGCGCACCTCGCCGCGTACAAGCTCGGCGCGATCGCGGTGCC
GCTCTTCACATTGTTCGGCGTCGATGCGCTCGAATACCGGCTTGCAAACAGCGAGGCGGCTGCGCTCGTCACCGACGCGG
CCGGCTACGCGAAAATCGCGCCGCTGCGCGCCCAGCTGCCGGCATTGCATACCGTCTACTGCATCGGCGACGATGCGCCC
GATCAGCCGGGCGTGCTGCACTACGACGCGGCGCTCGCCGCCGAAACGCCCGACTTCGTGCCGGCCGATACGGCCGCCGA
CGATCCGGCGGTCATCATCTACACGTCCGGCACGACGGGCAAACCGAAAGGCGCGTTGCACGCGCATCGCGTGCTGCTGG
GCCACCTGCCGGGCGTCGAGATGTCGCAGCAGTGCTTCCCGCGCGACGCGCGCCTGTTCTGGACGCCCGCCGACTGGGCA
TGGATCGGCGGCCTGCTCGACGTGCTGTTGCCGTCGTGGCATCACGGCGTGCCGGTGCTTGCGCGCCGCTTCGAGAAATT
CGACGGCGATGCGGCATTCGCGCTGATGGCACGGCACGGCGTCACCCATGCGTTCCTGCCGCCCACCGCGCTGAAGCTGA
TGCGCACCGTCGCGGCACCGCGCGAACGCTACGCGCTGTCGCTGAAATCCGTCGCGAGCGGCGGTGAGTCGCTCGGCACC
GAGCTGACGGCCTGGGGGCGCGACGCGCTCGGCGTGACGATCAACGAGTTCTACGGGCAAACCGAGTGCAACATGGTGCT
GTCGTCGTGCGCGGCACTGTTCGACGCGCAGCTGGGCGCAATCGGCAAGGCGGTGCCCGGCCATGCGGTCGCGATCGTCG
ACGCGGACGGCATGCCACTGCCGCCCGGCGTCGAAGGACGCATCGCGGTGCGTCGCCCCGACCCGGTGATGTTCCTCGAA
TACTGGCGCAACGCCGACGCGACGCGCGCCAAGTTCGCCGGCGACTACCTGCTCACCGGCGACACGGGCACGATCGACGC
GGACGGCTTCGTGCGCTTCGTCGGCCGCGACGACGACGTGATCACGAGCGCCGGCTACCGGATCGGCCCGGGCCCGATCG
AGGACTGCCTGCTCACGCATCCTGCGGTGCGGATGGCGGCCGCCGTCGGCGTGCCCGACGCGACGCGCACCGAGATCGTC
AAGGCGTTCATCGTGCTGAATCCCGGCCACATCGGCGACGATGCGCTCGTGCAGGCGCTGCAGGCACATGTGCGCACACG
CCTCGCCGCGCACGAGTATCCGCGCGCGATCGCGTTCGTCGACAGCCTGCCGATGACCGCGACCGGCAAGATCGTGCGCC
GTGCGCTGCGCGACGCGTAG

Upstream 100 bases:

>100_bases
GAAGATTCCCTACCCTCAGACGCCATTGTGGATTTTTCTGCGTGAAATCCTGATGTAAGCCGCTCGCGCAACACCACGTT
CGCCCCCAGGAGACACCTCG

Downstream 100 bases:

>100_bases
GCCGGCCGCCACCCGAGCCGCCCGCTGGGCCGGATGGTTTATAGTGGCGCCACTACGCAGTCTTTCCAAGAAAACGATGT
CCTCTGATCACCACTCCGAC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MLPAADRYDDLLSRFAWGVPARYNIGVDVCDKWADGSGRLALIHETAQGDVFRITFDDLKNASNRLANSFVRAGLRRGDR
IGIFLAQGPETAIAHLAAYKLGAIAVPLFTLFGVDALEYRLANSEAAALVTDAAGYAKIAPLRAQLPALHTVYCIGDDAP
DQPGVLHYDAALAAETPDFVPADTAADDPAVIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQQCFPRDARLFWTPADWA
WIGGLLDVLLPSWHHGVPVLARRFEKFDGDAAFALMARHGVTHAFLPPTALKLMRTVAAPRERYALSLKSVASGGESLGT
ELTAWGRDALGVTINEFYGQTECNMVLSSCAALFDAQLGAIGKAVPGHAVAIVDADGMPLPPGVEGRIAVRRPDPVMFLE
YWRNADATRAKFAGDYLLTGDTGTIDADGFVRFVGRDDDVITSAGYRIGPGPIEDCLLTHPAVRMAAAVGVPDATRTEIV
KAFIVLNPGHIGDDALVQALQAHVRTRLAAHEYPRAIAFVDSLPMTATGKIVRRALRDA

Sequences:

>Translated_539_residues
MLPAADRYDDLLSRFAWGVPARYNIGVDVCDKWADGSGRLALIHETAQGDVFRITFDDLKNASNRLANSFVRAGLRRGDR
IGIFLAQGPETAIAHLAAYKLGAIAVPLFTLFGVDALEYRLANSEAAALVTDAAGYAKIAPLRAQLPALHTVYCIGDDAP
DQPGVLHYDAALAAETPDFVPADTAADDPAVIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQQCFPRDARLFWTPADWA
WIGGLLDVLLPSWHHGVPVLARRFEKFDGDAAFALMARHGVTHAFLPPTALKLMRTVAAPRERYALSLKSVASGGESLGT
ELTAWGRDALGVTINEFYGQTECNMVLSSCAALFDAQLGAIGKAVPGHAVAIVDADGMPLPPGVEGRIAVRRPDPVMFLE
YWRNADATRAKFAGDYLLTGDTGTIDADGFVRFVGRDDDVITSAGYRIGPGPIEDCLLTHPAVRMAAAVGVPDATRTEIV
KAFIVLNPGHIGDDALVQALQAHVRTRLAAHEYPRAIAFVDSLPMTATGKIVRRALRDA
>Mature_539_residues
MLPAADRYDDLLSRFAWGVPARYNIGVDVCDKWADGSGRLALIHETAQGDVFRITFDDLKNASNRLANSFVRAGLRRGDR
IGIFLAQGPETAIAHLAAYKLGAIAVPLFTLFGVDALEYRLANSEAAALVTDAAGYAKIAPLRAQLPALHTVYCIGDDAP
DQPGVLHYDAALAAETPDFVPADTAADDPAVIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQQCFPRDARLFWTPADWA
WIGGLLDVLLPSWHHGVPVLARRFEKFDGDAAFALMARHGVTHAFLPPTALKLMRTVAAPRERYALSLKSVASGGESLGT
ELTAWGRDALGVTINEFYGQTECNMVLSSCAALFDAQLGAIGKAVPGHAVAIVDADGMPLPPGVEGRIAVRRPDPVMFLE
YWRNADATRAKFAGDYLLTGDTGTIDADGFVRFVGRDDDVITSAGYRIGPGPIEDCLLTHPAVRMAAAVGVPDATRTEIV
KAFIVLNPGHIGDDALVQALQAHVRTRLAAHEYPRAIAFVDSLPMTATGKIVRRALRDA

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI115511026, Length=549, Percent_Identity=32.2404371584699, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI38505220, Length=534, Percent_Identity=33.5205992509363, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI157311624, Length=542, Percent_Identity=33.0258302583026, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI157311622, Length=542, Percent_Identity=33.0258302583026, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI42544132, Length=545, Percent_Identity=30.4587155963303, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI122937307, Length=541, Percent_Identity=32.7171903881701, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI58082049, Length=542, Percent_Identity=32.6568265682657, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI13375727, Length=562, Percent_Identity=29.3594306049822, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI28416953, Length=569, Percent_Identity=27.0650263620387, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI8923896, Length=611, Percent_Identity=25.69558101473, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI253970489, Length=624, Percent_Identity=25.1602564102564, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI187761345, Length=532, Percent_Identity=27.2556390977444, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI187761343, Length=532, Percent_Identity=27.2556390977444, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI195947378, Length=446, Percent_Identity=27.3542600896861, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI156151445, Length=539, Percent_Identity=26.7161410018553, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI42544134, Length=378, Percent_Identity=23.8095238095238, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI40807357, Length=443, Percent_Identity=26.86230248307, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1788107, Length=572, Percent_Identity=27.6223776223776, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1790505, Length=558, Percent_Identity=26.8817204301075, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI221142682, Length=530, Percent_Identity=26.7924528301887, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1786529, Length=574, Percent_Identity=27.0034843205575, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI145693145, Length=506, Percent_Identity=27.8656126482213, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1786810, Length=508, Percent_Identity=27.755905511811, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1786801, Length=518, Percent_Identity=24.9034749034749, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788595, Length=496, Percent_Identity=26.2096774193548, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=504, Percent_Identity=27.1825396825397, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71982997, Length=546, Percent_Identity=25.4578754578755, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983001, Length=546, Percent_Identity=25.4578754578755, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17557194, Length=525, Percent_Identity=24.952380952381, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17531443, Length=510, Percent_Identity=22.7450980392157, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559526, Length=546, Percent_Identity=25.0915750915751, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17560140, Length=519, Percent_Identity=24.4701348747592, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=498, Percent_Identity=25.1004016064257, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32563687, Length=473, Percent_Identity=24.1014799154334, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994694, Length=520, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71994703, Length=520, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71994690, Length=520, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17560308, Length=523, Percent_Identity=23.3269598470363, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=525, Percent_Identity=24.1904761904762, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=367, Percent_Identity=25.0681198910082, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323182, Length=573, Percent_Identity=28.2722513089005, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319264, Length=583, Percent_Identity=27.1012006861063, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319699, Length=495, Percent_Identity=24.8484848484848, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24667955, Length=613, Percent_Identity=25.7748776508972, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI62472339, Length=535, Percent_Identity=27.1028037383178, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI21355225, Length=549, Percent_Identity=26.4116575591985, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24667959, Length=499, Percent_Identity=26.8537074148297, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19922652, Length=503, Percent_Identity=26.6401590457256, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24656500, Length=509, Percent_Identity=28.0943025540275, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18859661, Length=511, Percent_Identity=25.440313111546, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24581924, Length=519, Percent_Identity=25.2408477842004, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356947, Length=496, Percent_Identity=24.1935483870968, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355181, Length=524, Percent_Identity=22.9007633587786, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45550496, Length=557, Percent_Identity=23.6983842010772, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45552801, Length=557, Percent_Identity=23.6983842010772, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20130357, Length=522, Percent_Identity=24.7126436781609, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24648260, Length=490, Percent_Identity=23.6734693877551, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281365686, Length=358, Percent_Identity=22.6256983240223, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24653035, Length=359, Percent_Identity=23.9554317548747, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648253, Length=482, Percent_Identity=22.6141078838174, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648255, Length=482, Percent_Identity=22.4066390041494, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648257, Length=422, Percent_Identity=25.1184834123223, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076582, Length=366, Percent_Identity=22.4043715846995, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 57693; Mature: 57693

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPAADRYDDLLSRFAWGVPARYNIGVDVCDKWADGSGRLALIHETAQGDVFRITFDDLK
CCCCCHHHHHHHHHHHCCCCCEEECCHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHH
NASNRLANSFVRAGLRRGDRIGIFLAQGPETAIAHLAAYKLGAIAVPLFTLFGVDALEYR
HHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHE
LANSEAAALVTDAAGYAKIAPLRAQLPALHTVYCIGDDAPDQPGVLHYDAALAAETPDFV
ECCCCCEEEEECCCCCCEECCHHHHCCCEEEEEEECCCCCCCCCEEEECCCHHCCCCCCC
PADTAADDPAVIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQQCFPRDARLFWTPADWA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCCHH
WIGGLLDVLLPSWHHGVPVLARRFEKFDGDAAFALMARHGVTHAFLPPTALKLMRTVAAP
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEECCCHHHHHHHHHHHCC
RERYALSLKSVASGGESLGTELTAWGRDALGVTINEFYGQTECNMVLSSCAALFDAQLGA
HHHHHHHHHHHHCCCHHHCCCHHHCCCCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHHH
IGKAVPGHAVAIVDADGMPLPPGVEGRIAVRRPDPVMFLEYWRNADATRAKFAGDYLLTG
HCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCHHHHCCCEEEEC
DTGTIDADGFVRFVGRDDDVITSAGYRIGPGPIEDCLLTHPAVRMAAAVGVPDATRTEIV
CCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCHHHHHE
KAFIVLNPGHIGDDALVQALQAHVRTRLAAHEYPRAIAFVDSLPMTATGKIVRRALRDA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLPAADRYDDLLSRFAWGVPARYNIGVDVCDKWADGSGRLALIHETAQGDVFRITFDDLK
CCCCCHHHHHHHHHHHCCCCCEEECCHHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHH
NASNRLANSFVRAGLRRGDRIGIFLAQGPETAIAHLAAYKLGAIAVPLFTLFGVDALEYR
HHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHE
LANSEAAALVTDAAGYAKIAPLRAQLPALHTVYCIGDDAPDQPGVLHYDAALAAETPDFV
ECCCCCEEEEECCCCCCEECCHHHHCCCEEEEEEECCCCCCCCCEEEECCCHHCCCCCCC
PADTAADDPAVIIYTSGTTGKPKGALHAHRVLLGHLPGVEMSQQCFPRDARLFWTPADWA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCCHH
WIGGLLDVLLPSWHHGVPVLARRFEKFDGDAAFALMARHGVTHAFLPPTALKLMRTVAAP
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEECCCHHHHHHHHHHHCC
RERYALSLKSVASGGESLGTELTAWGRDALGVTINEFYGQTECNMVLSSCAALFDAQLGA
HHHHHHHHHHHHCCCHHHCCCHHHCCCCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHHH
IGKAVPGHAVAIVDADGMPLPPGVEGRIAVRRPDPVMFLEYWRNADATRAKFAGDYLLTG
HCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCHHHHCCCEEEEC
DTGTIDADGFVRFVGRDDDVITSAGYRIGPGPIEDCLLTHPAVRMAAAVGVPDATRTEIV
CCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCHHHHHE
KAFIVLNPGHIGDDALVQALQAHVRTRLAAHEYPRAIAFVDSLPMTATGKIVRRALRDA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]