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The map label for this gene is uvrC

Identifier: 78065727

GI number: 78065727

Start: 1189707

End: 1191740

Strand: Direct

Name: uvrC

Synonym: Bcep18194_A4255

Alternate gene names: 78065727

Gene position: 1189707-1191740 (Clockwise)

Preceding gene: 78065723

Following gene: 78065728

Centisome position: 32.21

GC content: 67.5

Gene sequence:

>2034_bases
ATGACATCCCCTGAAGCTTCCGATACCCCGTTCGAACCGAAGAAGATCCTTGCGCAGTTGCCGCACATGCCGGGCGTCTA
TCGCTATTACGACACGGCGGGTGCCGTGCTCTATGTCGGCAAGGCACGCGACCTGAAGAAGCGCGTATCGAGCTATTTCA
CGAAGACGCAGCTGTCGCCGCGCATCGCGATGATGGTCACGCGCATCGCGCGCATCGAGACGACCGTCACGCGCTCGGAG
GCCGAGGCGCTGCTGCTCGAGAACAACCTGATCAAGGCGCTCGCGCCGCGCTACAACATCCTGTTTCGCGACGACAAGTC
GTATCCGTACCTGAAGCTCACCGCACACCGTTTTCCGCGGATGGCCTACTACCGCGGCTCGGTCGACAAGCAGAACCAGT
ATTTCGGGCCGTTCCCGAGCGCCTGGGCCGTGCGCGAGAGCATCCAGATCCTGCAGCGCGTGTTCCAGTTGCGCACCTGC
GAGGACTCGGTCTTCAACAACCGCACGCGGCCGTGCCTGCTGCACCAGATCGGGCGCTGCACGGCGCCGTGCGTCGGCGC
GATCTCCGACGAGGATTACGCGATCGACGTATCGAACGCCGCGCGCTTCCTGCTCGGCCGGCAGTCCGAAGTGATGAAGG
AGCTCGAGCAGAAGATGCACGCGTTCGCGGCCGAGCTGAAATTCGAGCAGGCGGCGGCCGTGCGCAACCAGATGAGCTCG
CTCGCGACGGTGCTGCACCAGCAGGCGATCGAGGTCGGCAGCGACAGCGACGTCGATATCCTGGCCGTCGTTGCACAGGG
CGGGCGCGTGTGCGTGAATCTCGCGATGGTGCGCGGCGGCCGGCATCTCGGCGACAAGGCGTATTTCCCGACGCACGTCG
AAAGCGCGCTGACGCTCGCCGAGGGCGGTATCGGCGACGAGTCCGAACTGGCGGAGGCGGTGGATGCGCCCGCCGATGCC
ATGCCCGACCTGCCCGCGGAAGAACCCGGCCGTGCGCGCAGCGACGCGGCGGCGTCGGTCGAGGCGGAAGTGCTCGACGC
GTTCATCGCGCAGCACTATCTCGGCAATCGCGTACCGCCCGTGCTGGTCGTGAGCCATGCACCCGCGAGCCGCGACCTGC
TCGAGCTGCTGTCCGAGCAGGCCGGCCACAAGGTGTCGCTGGTGCGGCAGCCGCAGGGGCAGCGGCGAGCGTGGCTGTCG
ATGGCCGAACAGAATGCGCAGATCGCGCTCATGCGGCTGCTGTCCGAGCAGGGCTCGCAGCAGGCGCGCACGCGGGCGCT
CGCAGAGACGCTCAGCTACGAATGCGACGATCTCACGACGCTGCGGATCGAATGCTTCGACATCAGCCATACGATGGGCG
AGGCGACGCAGGCGTCGTGCGTGGTCTACCACCATCACAAGATGCAGTCGGGCGAATACCGCCGCTACAACATCACCGGG
ATCACGCCGGGCGACGACTACGCGGCGATGCGGCAGGTGCTCACGCGCCGCTACGAGAAGATGGTCGAGCAGGCCGCGCA
GGCGGCTGCCGCCGACGATGCGGCCGGGATCGACGGCGAGTCGACGCGCCAGGCCGAGGCGTCGAGCCTGCTGCCGAACA
TCGTGCTGATCGACGGCGGCAAGGGTCAGGTCGAAATCGCGCGCCAGGTGTTCACCGAGCTCGGTCTCGACACGTCGATG
CTGGTGGGCGTCGCGAAAGGCGAGGGGCGCAAGGTTGGCCTCGAGACGCTGGTGTTCGCGGACGGACGCACGCCGCTCGA
ACTCGGCAAGGAGAGCGCCGCGCTGATGGTCGTCGCGCAGATCCGCGACGAGGCGCACCGTTTCGCGATCACCGGCATGC
GCGCCAAGCGGGCGAAGGCGCGCCAGACGTCGCGGCTCGAGGAGCTGGAGGGTGTCGGCGCGAAGCGCCGGCAGCGGCTG
CTCGCGCGGTTCGGCGGGTTGCGCGGCGTCGTTGCCGCGAGTGTCGAGGAACTCGCGAGCGTCGAGGGCATCTCGCACGC
GCTCGCCGAGCAGATCTACAAGCAGCTTCACTGA

Upstream 100 bases:

>100_bases
GGGGGCAGCGGTGGTGCGGGGCATCGAAGCGGGCCGGTGAATGCTCTAAACTGGCGATTCTAATAGACCCGTTCCGCGTT
ACAAGGCGCCCGGATCACGC

Downstream 100 bases:

>100_bases
CGCGGCCGTGCGGCCGGCTGCCTTGCCAGCGTTCTTGTGGCAGGCCGGTCGACACGGCACAATTGCGAATCCTTTACTGT
CCCGCATGCCATGCCGTTCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MTSPEASDTPFEPKKILAQLPHMPGVYRYYDTAGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCTAPCVGAISDEDYAIDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGIGDESELAEAVDAPADA
MPDLPAEEPGRARSDAAASVEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLS
MAEQNAQIALMRLLSEQGSQQARTRALAETLSYECDDLTTLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITG
ITPGDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSM
LVGVAKGEGRKVGLETLVFADGRTPLELGKESAALMVVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRL
LARFGGLRGVVAASVEELASVEGISHALAEQIYKQLH

Sequences:

>Translated_677_residues
MTSPEASDTPFEPKKILAQLPHMPGVYRYYDTAGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSE
AEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTC
EDSVFNNRTRPCLLHQIGRCTAPCVGAISDEDYAIDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGIGDESELAEAVDAPADA
MPDLPAEEPGRARSDAAASVEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLS
MAEQNAQIALMRLLSEQGSQQARTRALAETLSYECDDLTTLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITG
ITPGDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSM
LVGVAKGEGRKVGLETLVFADGRTPLELGKESAALMVVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRL
LARFGGLRGVVAASVEELASVEGISHALAEQIYKQLH
>Mature_676_residues
TSPEASDTPFEPKKILAQLPHMPGVYRYYDTAGAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMVTRIARIETTVTRSEA
EALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPRMAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCE
DSVFNNRTRPCLLHQIGRCTAPCVGAISDEDYAIDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSSL
ATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLAEGGIGDESELAEAVDAPADAM
PDLPAEEPGRARSDAAASVEAEVLDAFIAQHYLGNRVPPVLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSM
AEQNAQIALMRLLSEQGSQQARTRALAETLSYECDDLTTLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITGI
TPGDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGGKGQVEIARQVFTELGLDTSML
VGVAKGEGRKVGLETLVFADGRTPLELGKESAALMVVAQIRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLL
ARFGGLRGVVAASVEELASVEGISHALAEQIYKQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=676, Percent_Identity=43.1952662721894, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1788037, Length=193, Percent_Identity=27.4611398963731, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 74454; Mature: 74323

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPEASDTPFEPKKILAQLPHMPGVYRYYDTAGAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCCHHHHHHHCCCCCCHHHEECCCCEEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHCCC
MAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TAPCVGAISDEDYAIDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
CCCCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
EGGIGDESELAEAVDAPADAMPDLPAEEPGRARSDAAASVEAEVLDAFIAQHYLGNRVPP
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQNAQIALMRLLSEQGSQ
EEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCHH
QARTRALAETLSYECDDLTTLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITG
HHHHHHHHHHHCCCCCCCEEEEEEEEECHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEE
ITPGDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEEECC
KGQVEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRTPLELGKESAALMVVAQ
CCHHHHHHHHHHHHCCCHHHEEEEECCCCCEECCEEEEEECCCCHHHHCCCCHHHHHHHH
IRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVEELAS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
VEGISHALAEQIYKQLH
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSPEASDTPFEPKKILAQLPHMPGVYRYYDTAGAVLYVGKARDLKKRVSSYFTKTQLSP
CCCCCCCCCCCHHHHHHHCCCCCCHHHEECCCCEEEEECCHHHHHHHHHHHHHHHCCCH
RIAMMVTRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTAHRFPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHCCC
MAYYRGSVDKQNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRC
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
TAPCVGAISDEDYAIDVSNAARFLLGRQSEVMKELEQKMHAFAAELKFEQAAAVRNQMSS
CCCCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATVLHQQAIEVGSDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPTHVESALTLA
HHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHH
EGGIGDESELAEAVDAPADAMPDLPAEEPGRARSDAAASVEAEVLDAFIAQHYLGNRVPP
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
VLVVSHAPASRDLLELLSEQAGHKVSLVRQPQGQRRAWLSMAEQNAQIALMRLLSEQGSQ
EEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCHH
QARTRALAETLSYECDDLTTLRIECFDISHTMGEATQASCVVYHHHKMQSGEYRRYNITG
HHHHHHHHHHHCCCCCCCEEEEEEEEECHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEE
ITPGDDYAAMRQVLTRRYEKMVEQAAQAAAADDAAGIDGESTRQAEASSLLPNIVLIDGG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEEEEEECC
KGQVEIARQVFTELGLDTSMLVGVAKGEGRKVGLETLVFADGRTPLELGKESAALMVVAQ
CCHHHHHHHHHHHHCCCHHHEEEEECCCCCEECCEEEEEECCCCHHHHCCCCHHHHHHHH
IRDEAHRFAITGMRAKRAKARQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVEELAS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
VEGISHALAEQIYKQLH
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA