Click here to switch to the map view.

The map label for this gene is panB

Identifier: 78065316

GI number: 78065316

Start: 750101

End: 750916

Strand: Reverse

Name: panB

Synonym: Bcep18194_A3842

Alternate gene names: 78065316

Gene position: 750916-750101 (Counterclockwise)

Preceding gene: 78065317

Following gene: 78065308

Centisome position: 20.33

GC content: 68.38

Gene sequence:

>816_bases
ATGACCTATCTCCAGGAATCGAGCCGGCCTGCCGTCACGGTGCCCAAGCTGCAGGCAATGCGCGACGCCGGCGAGAAGAT
CGCGATGCTCACCTGCTACGACGCGAGCTTTTCCGCACTGCTCGACCGTTCGGGCGTCGACGTGCTGCTGATCGGCGATT
CGCTCGGCAACGTGCTGCAAGGCCACACGACCACGCTGCCCGTGTCGCTCGACGACATCGCGTATCACACCGCCTGTGTT
GCCCGCGCGCAGCCGCGCGCGCTGATCATGGCCGACCTGCCGTTCGGCACGTACGGCACGCCGGCCGAGGCATTCGCAAG
CAGCGTCAAGCTGATGCGCGCCGGTGCGCAGATGGTCAAGCTCGAAGGCGGCGAATGGCTCGCCGAGACGATCCGCTTCC
TCGTCGAGCGCGCGGTGCCCGTATGTGCGCACGTGGGCCTCACGCCTCAGTCGGTCCACGCGTTCGGCGGCTTCAAGGTA
CAGGGCAAGACCGAAGCCGGCGCCGCGCAACTGCTGCGCGACGCGCGCGCGGTCGAAGCGGCGGGTGCGCAGGTCGTGCT
GCTCGAAGCCGTGCCGACGCTGATCGGGTCCGAGGTCACGCACATGCTGCGCGTGCCGACGATCGGCATCGGCGCGGGCG
CCGACTGCTCGGGCCAGGTGCTCGTGCTGCACGACATGCTCGGCGTGTTCCCCGGCAAGCGGCCGCGCTTCGTGAAGGAT
TTCATGCAGGGCGAGCCGAACATCCAGGCGGCCGTCGAAGCTTACGTGCGCGCGGTCAAGGACGGTTCGTTCCCCGGCCC
CGAGCATTCGTTCTGA

Upstream 100 bases:

>100_bases
CGAGACGATGCGCGGCCGCAAGGAATTCTTCGTCAAGGGCGAGACGACGCGCTGACGCGTCCTCGCCTGTCGTTCTTCAC
CCATTCGAACCGGATTTCCC

Downstream 100 bases:

>100_bases
CGTCTGTCGCGGCGCCGGCGATGCGTTTGCCTGCGCCTCGATGAAAAAAGCGCGGCGCCCTTTGCGGGGCGCCGCGCTTT
TTCTTTCCTGCGCTGCCAGC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase 1; KPHMT 1 [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFSALLDRSGVDVLLIGDSLGNVLQGHTTTLPVSLDDIAYHTACV
ARAQPRALIMADLPFGTYGTPAEAFASSVKLMRAGAQMVKLEGGEWLAETIRFLVERAVPVCAHVGLTPQSVHAFGGFKV
QGKTEAGAAQLLRDARAVEAAGAQVVLLEAVPTLIGSEVTHMLRVPTIGIGAGADCSGQVLVLHDMLGVFPGKRPRFVKD
FMQGEPNIQAAVEAYVRAVKDGSFPGPEHSF

Sequences:

>Translated_271_residues
MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFSALLDRSGVDVLLIGDSLGNVLQGHTTTLPVSLDDIAYHTACV
ARAQPRALIMADLPFGTYGTPAEAFASSVKLMRAGAQMVKLEGGEWLAETIRFLVERAVPVCAHVGLTPQSVHAFGGFKV
QGKTEAGAAQLLRDARAVEAAGAQVVLLEAVPTLIGSEVTHMLRVPTIGIGAGADCSGQVLVLHDMLGVFPGKRPRFVKD
FMQGEPNIQAAVEAYVRAVKDGSFPGPEHSF
>Mature_270_residues
TYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFSALLDRSGVDVLLIGDSLGNVLQGHTTTLPVSLDDIAYHTACVA
RAQPRALIMADLPFGTYGTPAEAFASSVKLMRAGAQMVKLEGGEWLAETIRFLVERAVPVCAHVGLTPQSVHAFGGFKVQ
GKTEAGAAQLLRDARAVEAAGAQVVLLEAVPTLIGSEVTHMLRVPTIGIGAGADCSGQVLVLHDMLGVFPGKRPRFVKDF
MQGEPNIQAAVEAYVRAVKDGSFPGPEHSF

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=259, Percent_Identity=52.1235521235521, Blast_Score=287, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6319653, Length=278, Percent_Identity=33.8129496402878, Blast_Score=169, Evalue=5e-43,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28686; Mature: 28555

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFSALLDRSGVDVLLIGDSLGNVLQ
CCCCCCCCCCCEECHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCCEEEEECCCHHHHHC
GHTTTLPVSLDDIAYHTACVARAQPRALIMADLPFGTYGTPAEAFASSVKLMRAGAQMVK
CCCEEECEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
LEGGEWLAETIRFLVERAVPVCAHVGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAVEA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHH
AGAQVVLLEAVPTLIGSEVTHMLRVPTIGIGAGADCSGQVLVLHDMLGVFPGKRPRFVKD
CCCCEEEHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHH
FMQGEPNIQAAVEAYVRAVKDGSFPGPEHSF
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TYLQESSRPAVTVPKLQAMRDAGEKIAMLTCYDASFSALLDRSGVDVLLIGDSLGNVLQ
CCCCCCCCCCEECHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCCEEEEECCCHHHHHC
GHTTTLPVSLDDIAYHTACVARAQPRALIMADLPFGTYGTPAEAFASSVKLMRAGAQMVK
CCCEEECEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
LEGGEWLAETIRFLVERAVPVCAHVGLTPQSVHAFGGFKVQGKTEAGAAQLLRDARAVEA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHH
AGAQVVLLEAVPTLIGSEVTHMLRVPTIGIGAGADCSGQVLVLHDMLGVFPGKRPRFVKD
CCCCEEEHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEEEEHHHHHCCCCCCHHHHH
FMQGEPNIQAAVEAYVRAVKDGSFPGPEHSF
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA