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The map label for this gene is nrdB [H]

Identifier: 78065156

GI number: 78065156

Start: 568166

End: 569377

Strand: Direct

Name: nrdB [H]

Synonym: Bcep18194_A3680

Alternate gene names: 78065156

Gene position: 568166-569377 (Clockwise)

Preceding gene: 78065155

Following gene: 78065157

Centisome position: 15.38

GC content: 60.15

Gene sequence:

>1212_bases
ATGCTCAACTGGGATGAAGAGAAGACTGCCGTAACTCCCGCGAGCGGAGCGCAGCAAAACGCGATGCGCACCTCCGCAGG
AGCGGCTGTCGGACTGCAGGCTGCAACGCCTGCCGCCCATCAGGTCCGCGACATTTTCGAAGGCGATCTTGCGGTGCCGC
CGCAAGCATCGGCTGTTCCCGCCGGCGGTTCGGAAGCGCGGGTCAATGTCGCCGACAAGCGCATCATCAACGGCCAGACT
GACGTCAATCAGCTGGTGCCGTTCAAGTACAAGTGGGCGTGGGAAAAGTATCTGGCCGGTTGCGCGAACCACTGGATGCC
GCAGGAAATCAACATGTCCCGCGACATCGCTCTGTGGAAGGACCCGAACGGTCTGACCGAGGACGAGCGCCGCATCGTGA
AGCGCAACCTCGGTTTCTTCGTGACGGCCGATTCGCTCGCGGCGAACAACATCGTGCTCGGCACGTACCGCCACATCACG
GCGCCCGAGTGCCGGCAGTTCCTGCTGCGCCAGGCGTTCGAAGAGGCGATCCACACGCACGCGTACCAATACATTGTCGA
ATCGCTCGGTCTCGACGAAGGCGAGATCTTCAACGCGTACCACGAGGTCACGTCGATCCGCGCGAAGGACGAATTCCTGA
TCCCGTTCATCCACACGCTGACGGATCCGGCCTTCAAGACCGGCACGCTCGAAGCGGATCAGAAGCTGCTGAAGTCGCTG
ATCGTGTTCGCCTGCATCATGGAAGGCCTGTTCTTCTATGTCGGGTTCACGCAGATCCTCGCGCTCGGCCGCCAGAACAA
GATGACGGGTGCTGCAGAGCAATATCAGTACATCCTGCGCGACGAGTCGATGCACTGCAACTTCGGCATCGACCTGATCA
ACCAGATCAAGCTCGAGAATCCGCATCTCTGGACCGCCGAATTCCGCGCCGAGATCCGCGAGCTGTTCAAGCAGGCTGTC
GAACTCGAATACCGCTACGCCGAAGACACGATGCCGCGCGGCGTGCTGGGTTTGAACGCGTCGATGTTCAAGAGCTATCT
GCGCTTCATCAGCAACCGCCGTTGCCAGCAGATCGGCCTTGACCCGCTGTATCCGAACGAGGAAAACCCGTTCCCGTGGA
TGAGCGAGATGATCGACCTGAAGAAGGAACGCAACTTCTTCGAGACGCGTGTGATCGAGTATCAGACGGGCGGTGCGCTG
TCCTGGGAATAA

Upstream 100 bases:

>100_bases
AGGTCGCAACGCGAATCGAAAAAAGGATTTTTCGTGAGCGAACCCTTTTATCGCTCAGGAAAAGATGGTACAAACCGTTC
TAAATTGATGGTGAGAATTT

Downstream 100 bases:

>100_bases
CCCGCAGCAGCGAACCCGTCACATGATGGTGCAGCCGGCGGCCTCTCGGCCCCGGCCCAAGGTTTAGGAGCAAGAACGCC
TGATGCAAAGCATGCCCGGT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MLNWDEEKTAVTPASGAQQNAMRTSAGAAVGLQAATPAAHQVRDIFEGDLAVPPQASAVPAGGSEARVNVADKRIINGQT
DVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHIT
APECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSL
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAV
ELEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL
SWE

Sequences:

>Translated_403_residues
MLNWDEEKTAVTPASGAQQNAMRTSAGAAVGLQAATPAAHQVRDIFEGDLAVPPQASAVPAGGSEARVNVADKRIINGQT
DVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHIT
APECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSL
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAV
ELEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL
SWE
>Mature_403_residues
MLNWDEEKTAVTPASGAQQNAMRTSAGAAVGLQAATPAAHQVRDIFEGDLAVPPQASAVPAGGSEARVNVADKRIINGQT
DVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHIT
APECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSL
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKQAV
ELEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL
SWE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=358, Percent_Identity=26.536312849162, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4557845, Length=406, Percent_Identity=25.8620689655172, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI260064013, Length=406, Percent_Identity=25.8620689655172, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI42544136, Length=322, Percent_Identity=27.639751552795, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI289177076, Length=298, Percent_Identity=27.8523489932886, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1788567, Length=293, Percent_Identity=25.938566552901, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17551968, Length=389, Percent_Identity=26.2210796915167, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=22.6973684210526, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=27.2321428571429, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322434, Length=330, Percent_Identity=31.5151515151515, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.4375, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=27.5, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 45878; Mature: 45878

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNWDEEKTAVTPASGAQQNAMRTSAGAAVGLQAATPAAHQVRDIFEGDLAVPPQASAVP
CCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
AGGSEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWK
CCCCCCEEEHHHHHEECCCCCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
DPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTH
CCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AYQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLEN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCC
PHLWTAEFRAEIRELFKQAVELEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCC
DPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEEECCCCCCCC
>Mature Secondary Structure
MLNWDEEKTAVTPASGAQQNAMRTSAGAAVGLQAATPAAHQVRDIFEGDLAVPPQASAVP
CCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCC
AGGSEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWK
CCCCCCEEEHHHHHEECCCCCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
DPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTH
CCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AYQYIVESLGLDEGEIFNAYHEVTSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSL
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLEN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCC
PHLWTAEFRAEIRELFKQAVELEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCC
DPLYPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]