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The map label for this gene is mltA [H]

Identifier: 78065101

GI number: 78065101

Start: 498767

End: 499999

Strand: Direct

Name: mltA [H]

Synonym: Bcep18194_A3625

Alternate gene names: 78065101

Gene position: 498767-499999 (Clockwise)

Preceding gene: 78065100

Following gene: 78065107

Centisome position: 13.5

GC content: 67.64

Gene sequence:

>1233_bases
ATGAAGATCAGCAGGGCAAGCGCTACGAAGGCTTCGAGCGCGAAGATGAGCATCGGATATTGGTCGAGAAAATCTGACAT
GGCGGTTTCCATCAAGAACGGACATTGTATGTGGTTTGGGCCCCGGTTGGCCGGGTGGGTTGCGGCGGCCGCGGCAGCGG
CGCTGCTTGCGGCTTGTGGTGGTACGCCGACGCGGACGTCGTCGCTGAAGCCGCCGACAGGCGCGGCGATCGTGCCGGGT
CAGGTCGCCGCGAAGCGGCTCACGCCGGTCGCGTGGCAGCAGGTGCCGGGCTGGCAGGACGATTCGCTGATCGGTGCGAC
CGCCGCGCTGCGGCAGAACTGCGTGCGGCTCGCGCGCCAGCCGGCCTGGGCACGCGCTTGCGCTGCCGCTGACCGGCTCG
ACGAGCTCGACGTCAGCAGTGCACGTACGTTCTTCGAAACGTATTTCACGCCGTTCCAGCTCGCGAATACCGACGGGACG
CTCGACGGGCTTGTGACCGGCTATTACGAGCCGCTGCTGCATGGTTCGCGTGTGCGCCGCGGCCCGTATCAGTACGCGCT
CTACCGATGGCCCTCCGGTTATCGCGCGGGCGCCGCGCTGCCGGCACGCGCGCAGCTCGAACGCGCCGGCATCCTGAACG
GCAACGAACTCGTGTGGGTCGACGACCCGATCGAAGCGTTCTTCCTGCAGGTGCAGGGCTCGGGACGCGTGCTGCTCGAC
GACGGTTCGGTGATGCGGGTCGGCTTCGGCGGCACCAACAACCAGCCGTACCGCTCGATCGGCAAGTGGCTGCTCGATCG
CGGCGAGCTGACGCCCGCCCAGGCGACGATGCAGGGCATCAAGGCGTGGGCGAAGGCGAACCCGACCCGCGTCGACGCGT
TGCTCGACACGAACCCGCGATTCGTGTTCTTCCGCGACATGCCGACCAAGGAAGATGCGCCGCATGGCGGTGCGGACGGC
CCGATCGGCGCGCTGGGCGTGCCGCTGACGCCGGAGCGTTCGATTGCCGTCGATCCGTCGTCGATCCCGCTCGGCACTCC
GGTGTTCCTGCAGACCACGCGCCCGCTGACGAATACGCCGATGAACCGGCTCGTGTTCGCGCAGGATACGGGCTCAGCGA
TCAAGGGCGGCGTGCGGGCCGACTACTTCTGGGGGCTCGGCGACGATGCAGGCGATCAGGCAGGGCGGATGAAGCAGGTC
GGCCGGATGTGGCTGCTGTTCCCGAATTCGTGA

Upstream 100 bases:

>100_bases
GCACGCTGCATTGAGCGTGCGGAGCGCGTCAGGGCGTTAGCGCGGCTGGCGGTCGTTGCTGCGGGCATGCTTCTTTCTGC
CCGACGACGTCCACACGACG

Downstream 100 bases:

>100_bases
TGTGAGGCGGCGCGGGTGGCTTCGGTCGCTCGGGTCGCCGCCGATGCATTCGACGCGGTATTCGTAGACGCGACGATGGG
CGTGGGGTGCGTTGCCCTGA

Product: membrane-bound lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWVAAAAAAALLAACGGTPTRTSSLKPPTGAAIVPG
QVAAKRLTPVAWQQVPGWQDDSLIGATAALRQNCVRLARQPAWARACAAADRLDELDVSSARTFFETYFTPFQLANTDGT
LDGLVTGYYEPLLHGSRVRRGPYQYALYRWPSGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPRFVFFRDMPTKEDAPHGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDQAGRMKQV
GRMWLLFPNS

Sequences:

>Translated_410_residues
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWVAAAAAAALLAACGGTPTRTSSLKPPTGAAIVPG
QVAAKRLTPVAWQQVPGWQDDSLIGATAALRQNCVRLARQPAWARACAAADRLDELDVSSARTFFETYFTPFQLANTDGT
LDGLVTGYYEPLLHGSRVRRGPYQYALYRWPSGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPRFVFFRDMPTKEDAPHGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDQAGRMKQV
GRMWLLFPNS
>Mature_410_residues
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWVAAAAAAALLAACGGTPTRTSSLKPPTGAAIVPG
QVAAKRLTPVAWQQVPGWQDDSLIGATAALRQNCVRLARQPAWARACAAADRLDELDVSSARTFFETYFTPFQLANTDGT
LDGLVTGYYEPLLHGSRVRRGPYQYALYRWPSGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPRFVFFRDMPTKEDAPHGGADG
PIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDQAGRMKQV
GRMWLLFPNS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=381, Percent_Identity=30.1837270341207, Blast_Score=138, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44127; Mature: 44127

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWVAAAAAAALLAACG
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHC
GTPTRTSSLKPPTGAAIVPGQVAAKRLTPVAWQQVPGWQDDSLIGATAALRQNCVRLARQ
CCCCCCCCCCCCCCCEECCCHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
PAWARACAAADRLDELDVSSARTFFETYFTPFQLANTDGTLDGLVTGYYEPLLHGSRVRR
CHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCC
GPYQYALYRWPSGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCEEEEE
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPR
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FVFFRDMPTKEDAPHGGADGPIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDQAGRMKQVGRMWLLFPNS
CHHEEEEECCCHHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MKISRASATKASSAKMSIGYWSRKSDMAVSIKNGHCMWFGPRLAGWVAAAAAAALLAACG
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHC
GTPTRTSSLKPPTGAAIVPGQVAAKRLTPVAWQQVPGWQDDSLIGATAALRQNCVRLARQ
CCCCCCCCCCCCCCCEECCCHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHC
PAWARACAAADRLDELDVSSARTFFETYFTPFQLANTDGTLDGLVTGYYEPLLHGSRVRR
CHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCC
GPYQYALYRWPSGYRAGAALPARAQLERAGILNGNELVWVDDPIEAFFLQVQGSGRVLLD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCEEEEE
DGSVMRVGFGGTNNQPYRSIGKWLLDRGELTPAQATMQGIKAWAKANPTRVDALLDTNPR
CCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
FVFFRDMPTKEDAPHGGADGPIGALGVPLTPERSIAVDPSSIPLGTPVFLQTTRPLTNTP
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
MNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDQAGRMKQVGRMWLLFPNS
CHHEEEEECCCHHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]