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The map label for this gene is gabP [H]

Identifier: 78065085

GI number: 78065085

Start: 481948

End: 483339

Strand: Direct

Name: gabP [H]

Synonym: Bcep18194_A3609

Alternate gene names: 78065085

Gene position: 481948-483339 (Clockwise)

Preceding gene: 78065084

Following gene: 78065086

Centisome position: 13.05

GC content: 64.87

Gene sequence:

>1392_bases
ATGAGTGGAAGCAACACAGGCCTCGGTACGGGCCTGAAGCAGCGGCACGTGACGATGATGTCGATTGCCGGCGTGATCGG
CGCGGGCCTGTTCGTCGGCTCCGGCCACGCCATCGCCGAAGCCGGCCCGGCGTCGATCCTCGCGTATGCGATCGCGGGTG
TGCTGGTCGTGCTGGTGATGCGCATGCTCGGCGAGATGGCCGTTGCGCATCCGGACAGCGGCTCGTTCTCCACCTATGCC
GATCGCGCGATCGGCCATTGGGCCGGTTTCTCGATCGGCTGGCTGTACTGGTGGTTCTGGGTGCTCGTGATTCCGATCGA
GGCGACCGCCGCCGCGACCATCCTCAATGCCTGGTTCCCTGGTGTTGCAACCTGGGCCTTCGCACTCGGCATCACGCTGG
TGCTGACGGTGACCAACCTCTTTTCGGTCAAGAACTACGGCGAATTCGAATTCTGGTTCGCGCTGATCAAGGTCGTCGCG
ATCGTCGTGTTCCTGTGCATCGGCGGGGCGGCGATCGTCGGCATCATTCCGGCGCCGGCGGTGTCGGGCGTGTCGAACCT
GTTCGTGCATGACGGCTTCATGCCGCACGGCGCAGGCGCGGTGCTCGCGGCGATGCTGACGACGATGTTCTCGTTCCTCG
GCACCGAGATCGTGACGATCGCGGCCGCCGAATCGGACAACCCGCAACGCCAGATCGTGCGCGCGACCAACTCGGTGATC
TGGCGCATCACGCTGTTCTATCTCGGCTCGATTCTCGTCGTTGCGGCGATCGTGCCGTGGAACGACCCGTTGCTGCCGAA
GCACGGCTCGTATCAGCGCGCGATGGAGCTGATCGGCATCCCGAATGCGAAGGCGATCATCGACGTGATCGTGCTCGTGT
CGGTCGCGAGCTGCCTGAATTCGGCGCTGTACACCGCGTCGCGGATGCTGTTCTCGCTGTCCAAGCGCAAGGACGCACCG
GCGTTCCTGCACCGCACGGATTCGACCGGTACGCCGCGCGCGGCCGTGCTTGCATCGACCGCGTTCGGTTTCGTGACCGT
GATCGCGAACTACCTGATGCCGGAACAGGTGTTCGGCTTCCTGCTGGCGACGTCGGGCGCGATCGCGCTGCTCGTGTATC
TCGTGATCGCGATCTCGCAACTGCGGATGCGCAAGACGCTCGAATCGACCGGCGCGGACCTGACGCTGCGGATGTGGCTG
TTCCCGTGGCTCACGTGGTTGGTGATCGTGTTCATCTGCGGCACGCTGACCGTGATGCTCGTGAGCGAGGATCACCGGAT
GGAAGTGGGGGCGACGGCAGTGTTGGCGCTGATCGTGCTGCTCGCGTCGTGGCTGAACAAGCGTGGCCGCGATGCGCAGG
CGAGTGAAGGGCGGCGCGCGTCGGCGATGTGA

Upstream 100 bases:

>100_bases
GTGCAGGCGCCGCATCCGGCCCGGCTCAAGAACCACAATCCCCCGTGCTGCCTTCACGCGATGCCCGGCCATACCGGAAC
CGTTTTTTGGAGAGAGACAG

Downstream 100 bases:

>100_bases
TGGAGTGAAGTGATGGCGGGCGGAAAGCCCGCGTCACGAAAAATGGCCCGATCGGCGTTTGCCGGTCGGGCCATTTGCTT
TTTTATCCGATGCGGCGGAA

Product: GABA transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFSIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWAFALGITLVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLCIGGAAIVGIIPAPAVSGVSNLFVHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGIPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSKRKDAP
AFLHRTDSTGTPRAAVLASTAFGFVTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESTGADLTLRMWL
FPWLTWLVIVFICGTLTVMLVSEDHRMEVGATAVLALIVLLASWLNKRGRDAQASEGRRASAM

Sequences:

>Translated_463_residues
MSGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFSIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWAFALGITLVLTVTNLFSVKNYGEFEFWFALIKVVA
IVVFLCIGGAAIVGIIPAPAVSGVSNLFVHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGIPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSKRKDAP
AFLHRTDSTGTPRAAVLASTAFGFVTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESTGADLTLRMWL
FPWLTWLVIVFICGTLTVMLVSEDHRMEVGATAVLALIVLLASWLNKRGRDAQASEGRRASAM
>Mature_462_residues
SGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVMRMLGEMAVAHPDSGSFSTYAD
RAIGHWAGFSIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWAFALGITLVLTVTNLFSVKNYGEFEFWFALIKVVAI
VVFLCIGGAAIVGIIPAPAVSGVSNLFVHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVIW
RITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGIPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSKRKDAPA
FLHRTDSTGTPRAAVLASTAFGFVTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESTGADLTLRMWLF
PWLTWLVIVFICGTLTVMLVSEDHRMEVGATAVLALIVLLASWLNKRGRDAQASEGRRASAM

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=64.8837209302326, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1786302, Length=460, Percent_Identity=37.1739130434783, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.5291375291375, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI48994972, Length=463, Percent_Identity=35.85313174946, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1788480, Length=407, Percent_Identity=35.6265356265356, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI87081708, Length=405, Percent_Identity=36.5432098765432, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI87081915, Length=459, Percent_Identity=33.5511982570806, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1790653, Length=462, Percent_Identity=31.3852813852814, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1786602, Length=469, Percent_Identity=33.4754797441365, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081869, Length=243, Percent_Identity=29.2181069958848, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=432, Percent_Identity=33.3333333333333, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322892, Length=407, Percent_Identity=34.8894348894349, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=32.7586206896552, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=429, Percent_Identity=31.2354312354312, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=29.25, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=415, Percent_Identity=30.3614457831325, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324059, Length=420, Percent_Identity=30.952380952381, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=30.75, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6320251, Length=411, Percent_Identity=29.683698296837, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=416, Percent_Identity=30.0480769230769, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=29.0243902439024, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=423, Percent_Identity=27.8959810874704, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=481, Percent_Identity=28.6902286902287, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=476, Percent_Identity=28.3613445378151, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=28.9672544080605, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=394, Percent_Identity=29.9492385786802, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=26.3157894736842, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=469, Percent_Identity=23.8805970149254, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24668806, Length=398, Percent_Identity=22.6130653266332, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356285, Length=398, Percent_Identity=22.6130653266332, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24668802, Length=398, Percent_Identity=22.6130653266332, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49511; Mature: 49380

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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ECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGVLVVLVM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAHPDSGSFSTYADRAIGHWAGFSIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVATWAFALGITLVLTVTNLFSVKNYGEFEFWFALIKVVAIVVFLCIGGAAIVGIIPAPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCH
VSGVSNLFVHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCHHHHHHHHHHHHH
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGIPNAKAIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
SALYTASRMLFSLSKRKDAPAFLHRTDSTGTPRAAVLASTAFGFVTVIANYLMPEQVFGF
HHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRKTLESTGADLTLRMWLFPWLTWLVIVFICGTLTVML
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
VSEDHRMEVGATAVLALIVLLASWLNKRGRDAQASEGRRASAM
ECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]