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The map label for this gene is lrp [H]

Identifier: 78064898

GI number: 78064898

Start: 284449

End: 284973

Strand: Direct

Name: lrp [H]

Synonym: Bcep18194_A3421

Alternate gene names: 78064898

Gene position: 284449-284973 (Clockwise)

Preceding gene: 78064896

Following gene: 78064907

Centisome position: 7.7

GC content: 65.9

Gene sequence:

>525_bases
ATGGCGCAAGCCGAATTGGATGCCATCGACCGGCGGATTCTCGCGATTCTTCAGGAGAACGGGCGCCTGTCGAACCAGGA
GATCGCCGAGCGCGTGAACCTGTCGCCGAGCCCGTGCCTGCGGCGGATCCGGCGGCTCGAGGAGATCGGCGTGATCACCG
GCTATGTCGCGCTGCTGAATCCGCAGAAGCTCGGGCTCGACCTGCTCGCATACGTGAGCGTGCGGCTCGAGAAGCGCGGC
GGCCTGGCGCCGGTGCGGGCCGACGAAACGTCGGCGCGTGCGGGCGCGACCCATGCGGAGCTGTTTCGCGCGGCCGTGCA
GACCTGGCCGGAAGTGGTCGCGTGCCACGCGATGACGGGAGATATGGATTACCTGCTGCGCGTGCAGGTCGAGGACATGG
CGCATTTCTCCCGCTTCGTGCAGGAGCATCTGCTGCATCACCCGTCGGTGATCGACGTGAAGACGAGCTTTTCGCTCGAA
TGCTTCAAGGAGACGACCGCGTTGCCGATCCGATCGGTGCGCTAG

Upstream 100 bases:

>100_bases
GAGTGTAGCGGGCAGCTGCGAGCGTAAACTTGCGAACTTAATTGCCCGAACCTACGATGGCGCAATTTCCAGTCTCAAAC
TATTCATTGGAGGGCAGAAG

Downstream 100 bases:

>100_bases
TGCGCGGCGGGGAAGGGAGGGGCCGGGCGCGCGGCGGGCGCGGCCCGGCTGGCCGACATTACGCCGTCAGGGCGGCGGGC
ATCAGCGATTCGATGAACTT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MAQAELDAIDRRILAILQENGRLSNQEIAERVNLSPSPCLRRIRRLEEIGVITGYVALLNPQKLGLDLLAYVSVRLEKRG
GLAPVRADETSARAGATHAELFRAAVQTWPEVVACHAMTGDMDYLLRVQVEDMAHFSRFVQEHLLHHPSVIDVKTSFSLE
CFKETTALPIRSVR

Sequences:

>Translated_174_residues
MAQAELDAIDRRILAILQENGRLSNQEIAERVNLSPSPCLRRIRRLEEIGVITGYVALLNPQKLGLDLLAYVSVRLEKRG
GLAPVRADETSARAGATHAELFRAAVQTWPEVVACHAMTGDMDYLLRVQVEDMAHFSRFVQEHLLHHPSVIDVKTSFSLE
CFKETTALPIRSVR
>Mature_173_residues
AQAELDAIDRRILAILQENGRLSNQEIAERVNLSPSPCLRRIRRLEEIGVITGYVALLNPQKLGLDLLAYVSVRLEKRGG
LAPVRADETSARAGATHAELFRAAVQTWPEVVACHAMTGDMDYLLRVQVEDMAHFSRFVQEHLLHHPSVIDVKTSFSLEC
FKETTALPIRSVR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=168, Percent_Identity=41.6666666666667, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI87081742, Length=165, Percent_Identity=40.6060606060606, Blast_Score=125, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19498; Mature: 19367

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQAELDAIDRRILAILQENGRLSNQEIAERVNLSPSPCLRRIRRLEEIGVITGYVALLN
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PQKLGLDLLAYVSVRLEKRGGLAPVRADETSARAGATHAELFRAAVQTWPEVVACHAMTG
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DMDYLLRVQVEDMAHFSRFVQEHLLHHPSVIDVKTSFSLECFKETTALPIRSVR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AQAELDAIDRRILAILQENGRLSNQEIAERVNLSPSPCLRRIRRLEEIGVITGYVALLN
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PQKLGLDLLAYVSVRLEKRGGLAPVRADETSARAGATHAELFRAAVQTWPEVVACHAMTG
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DMDYLLRVQVEDMAHFSRFVQEHLLHHPSVIDVKTSFSLECFKETTALPIRSVR
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]