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The map label for this gene is maeB [H]

Identifier: 78064894

GI number: 78064894

Start: 276465

End: 278735

Strand: Direct

Name: maeB [H]

Synonym: Bcep18194_A3417

Alternate gene names: 78064894

Gene position: 276465-278735 (Clockwise)

Preceding gene: 78064886

Following gene: 78064896

Centisome position: 7.48

GC content: 65.52

Gene sequence:

>2271_bases
ATGGACGAACAACTGAAGCAGGCCGCACTCGCTTATCACCTGAACCCGAAACCCGGCAAGATTTCGGTCACCCCGACCAA
GCCGCTGTCGAACCAGCTGGATCTGTCGCTCGCGTATTCGCCGGGCGTCGCCGCCGCGTGCGAAGCGATCCACGCCGATC
CGCTCGACGCGCAGAAGTACACGTCGCGCGGCAACCTCGTCGGCGTCATCACGAACGGCACCGCCGTGCTCGGCCTCGGC
AACATCGGCCCGCTCGCCGCGAAGCCGGTGATGGAAGGCAAGGGCTGCCTCTTCAAGAAATTCGCGGGCATCGACGTGTT
CGACATCGAACTGTCGGAGTCCGACCCCGACAAGCTCGTCGAGGCGATCGCGATGCTCGAGCCGACGCTCGGCGGCATCA
ACCTCGAGGACATCAAGGCGCCGGAATGCTTCTACATCGAGCAGAAGCTGCGCGAGCGCATGAAGATCCCCGTCTTCCAC
GATGACCAGCACGGCACCGCGATCATCGCGTCGGCCGCGATCCTGAACGGCCTGAAGGTCGTCGACAAGAAGCTGTCCGA
AGTGAAGCTCGTGTGCTCGGGCGCGGGCGCAGCGGCGATCGCGTGTCTGGACCTGCTGGTGAACCTCGGCCTGACGAAGT
CGAACATCCTCGTCGCCGATTCGAAGGGCGTGATCTACGAAGGTCGCGGCAACCTCGATCCGTCGAAGCAGCGCTATGCG
GCGACCACCGACGCACGCACGCTCGCCGACGCGATCGTCGGCGCGGACGTGTTCCTCGGCTGCTCGAGCGCGGGCGTGCT
GAAGCAGGACATGGTCAAGACGATGGGCGACCGCCCGCTGATCCTGGCGCTCGCGAACCCGGAACCGGAAATCCGCCCGG
AAGACGCGAAGGCCGTGCGCCCGGACGCGATCGTCGCGACCGGCCGTTCGGACTACCCGAACCAGGTCAACAACGTGCTG
TGCTTCCCGTTCATCTTCCGCGGCGCGCTCGACGTCGGTGCGACGACGATCACGGAAGAAATGAAGCTCGCGTGCGTGCG
CGCGATTGCCGAGCTGGCACAGGAAACCGACCAGAGCGAAGAAGTCGCGAAGGCGTATGAAGGCCACTCGCTCGAGTTCG
GGCCGGACTACCTGATTCCGAAGCCGTTCGACCCGCGCCTGATCATCAAGATCGCGCCGGCCGTCGCACAGGCTGCGATG
GATTCGGGCGTTGCCACCCGTCCGATCCAGGACATGGACGCATACCGCGAGCAGCTCGGCGCGACCGTCTACCGCACCGG
CATGGTGATGCGCCCGGTGTTCGCCACCGCGAAGCAGAAGCAGGCCCGCATCGTGTTCGCCGAGGGCGAAGACGAGCGCG
TGCTGCGTGCCGCGCAGTTCGTGCTGCAGGAAAAGATCGCGAAGCCGATCCTCGTCGGCCGTCCGTCGGTCATCGACATG
CGCCTCGCGAAGATCGGTTCGAAGCTGAAGGCCGGCACCGATTTCGAAATCGTCGATCCGGAAGACGATGCGCGCTACCA
CCGCTACTGGCAGGCGTATCAAGAGATCGGCGCGCGCGACGGCGTGACGCCGGAAGTCGCGAAGGCCGCGATGCGCAAGT
TCAACACGCTGATCGGCGCGATGCTCGTGCACCTGGGCGACGCGGACGGCATGATCTGCGGGATGATCGACACGTTCCAC
AGCCACCTGAAGTTCATCGAGCAGGTGCTGGGCCGCGCGAAGGGCGCCGAGCACTTCGCGGCGATGAACCTGCTGATGCT
GCCGGGCCGCAACCTGTTCGTGTGCGATACGTACGTGAACGAGCTGCCGAGCGCCGAACAGCTCGCCGACATGACGATCC
AGGCCGCGGCCGAGATCGAGCGCTTCGGCATTGCGCCGAAGGCTGCGCTGCTGTCGAACTCGAACTTCGGCAGCGCGCCG
TCGGCGTCGTCGCGCCGGATGGGCGAGGCTCGCAAGCTGATCGTCGAACGTGCGCCGAACCTCGAAGTCGACGGTGAAAT
GCACGGCGACGCGGCGCTGTCGGAAATGATCCGCAAGCAGGCCTTCCCCGGCACGACGCTGTCGGGCGAAGCAAACCTGC
TGATCATGCCGAACGTCGAAGCGGCGAACATCGCGTACAACCTGCTGAAGATGGTCGGCGGCGAAGGCGTGACGGTCGGC
CCGTTCCTGCTCGGCGCGGCGAAGCCGGCCCACATCCTGACGCCGGCTGCGACCGTGCGCCGGATCATCAACATGACGGC
TGTTGCCGCCGCGAACGTGAACACGAAGTAA

Upstream 100 bases:

>100_bases
TGCCGTCTCGCAGTCGATCACCCCCTCGATTCAAGCAGACGCGGCCGAAGGTGCTGCGTACTGAACCGTCAATATTTCGC
ATGTCTCTCGCAGGTCAATC

Downstream 100 bases:

>100_bases
GTCCACGCCCGCGTGTGCCGCGCTTCGGGCGCGGCGCAATGAAAAACGCCACGGAACCTGCGTTCCGTGGCGTTTTTTTA
TCGTGACGTGACGTGACGTG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVDKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRGNLDPSKQRYA
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGDRPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFATAKQKQARIVFAEGEDERVLRAAQFVLQEKIAKPILVGRPSVIDM
RLAKIGSKLKAGTDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGAMLVHLGDADGMICGMIDTFH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSAEQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAP
SASSRRMGEARKLIVERAPNLEVDGEMHGDAALSEMIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPAHILTPAATVRRIINMTAVAAANVNTK

Sequences:

>Translated_756_residues
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVDKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRGNLDPSKQRYA
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGDRPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFATAKQKQARIVFAEGEDERVLRAAQFVLQEKIAKPILVGRPSVIDM
RLAKIGSKLKAGTDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGAMLVHLGDADGMICGMIDTFH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSAEQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAP
SASSRRMGEARKLIVERAPNLEVDGEMHGDAALSEMIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPAHILTPAATVRRIINMTAVAAANVNTK
>Mature_756_residues
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVDKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRGNLDPSKQRYA
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGDRPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFATAKQKQARIVFAEGEDERVLRAAQFVLQEKIAKPILVGRPSVIDM
RLAKIGSKLKAGTDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGAMLVHLGDADGMICGMIDTFH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSAEQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAP
SASSRRMGEARKLIVERAPNLEVDGEMHGDAALSEMIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPAHILTPAATVRRIINMTAVAAANVNTK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=356, Percent_Identity=28.0898876404494, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI62420882, Length=354, Percent_Identity=27.4011299435028, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI62420880, Length=354, Percent_Identity=27.4011299435028, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI239049447, Length=354, Percent_Identity=27.4011299435028, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI4505145, Length=359, Percent_Identity=27.0194986072423, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI270265879, Length=317, Percent_Identity=27.7602523659306, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=63.3245382585752, Blast_Score=977, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=341, Percent_Identity=29.6187683284457, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788800, Length=322, Percent_Identity=32.6086956521739, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081919, Length=411, Percent_Identity=23.6009732360097, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=30.5970149253731, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21356279, Length=402, Percent_Identity=26.6169154228856, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281362674, Length=404, Percent_Identity=26.4851485148515, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281362672, Length=404, Percent_Identity=26.4851485148515, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=29.7142857142857, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=29.7142857142857, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI78707242, Length=410, Percent_Identity=23.4146341463415, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78707238, Length=410, Percent_Identity=23.4146341463415, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78707240, Length=355, Percent_Identity=23.943661971831, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81034; Mature: 81034

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVITNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VDKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRGNLDPSKQRYA
HHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCCHHHHC
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGDRPLILALANPEPEIRPEDAKAVR
CCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFATAKQKQARIVFAEGEDERVLRAAQFVLQEKIAKPILVGRPSVIDM
CHHHHCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHH
RLAKIGSKLKAGTDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGA
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTFHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEHHHH
ELPSAEQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAPSASSRRMGEARKLIVERAPN
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEMIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPAHILTPAATVRRIINMTAVAAANVNTK
HHHHCCCCCCCEECCHHHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVITNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VDKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRGNLDPSKQRYA
HHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCCHHHHC
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGDRPLILALANPEPEIRPEDAKAVR
CCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFATAKQKQARIVFAEGEDERVLRAAQFVLQEKIAKPILVGRPSVIDM
CHHHHCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHH
RLAKIGSKLKAGTDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGA
HHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTFHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEHHHH
ELPSAEQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAPSASSRRMGEARKLIVERAPN
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEMIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPAHILTPAATVRRIINMTAVAAANVNTK
HHHHCCCCCCCEECCHHHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]