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The map label for this gene is 78064876

Identifier: 78064876

GI number: 78064876

Start: 257137

End: 258468

Strand: Direct

Name: 78064876

Synonym: Bcep18194_A3399

Alternate gene names: NA

Gene position: 257137-258468 (Clockwise)

Preceding gene: 78064875

Following gene: 78064881

Centisome position: 6.96

GC content: 70.95

Gene sequence:

>1332_bases
ATGACCGCACTCGATCTGAACCGCGGCGCGATCGCGCCGGTCGCCGACGAGATTGATCTCGTCGACCTGCGCGTGACCGG
CGCCATCCCGCACGAACTCGCCGGCACGTTGCTGCGCAACGGCCCGAATCCGCCGGGCGGCCGCTTCGAAGGGAGCGACA
TGCTGTCGTGGTGGCCGGAAGCCGCGATGCTGCACGCGATCGCGTTCGAAGGCGGCCGCGCGACCGGCTACCGGAACCGC
TGGGCGCGCACGCAGCGCTGGGCCGCCGTGCACGCACCTGAAGCGGCATCGCAGCTGCCCGACACCAACCCGAACGTGAA
CGTGCTGCAGCATGCCGGCGAATTGCTCGCGCTGTCGGAGGGCGGCGCGCCGTTCGCGATCACGGCCGCGCTCGATTCGC
TCGGCATACCGGCGCGGCACGCAGGCCTCGGCGGCGGGATGACCGCGCATCCGAAGGTCGATCCGGTGACCGGCGAGCTG
ATCGCGTTCCGCGCGGACTGGCGCGCACCGTGGCTGCGCTACGGTGTCGCCGATGCGCAGGGCGTGCAGCGCGTCGATCT
CGAGATCGACCTGAGCGCGCCGTCGATGATGCACGACCTCGCGATCACCGAAACCCGCAGCCTGCTGCTCGACCTGAACG
TCGGCTACGACTTCTCGCTGCTGAAGCTGGGCCACCGGATGCCGCTACGCTGGCACGACGACCGGCCCGCACGCATCGGC
GTGATCCCGCGTCATGGCGGCGCGGTGCGCTGGTTCGGCGTCGAGCCGTGTTTCATCCTGCACGTCGTGAACGCGTACGA
CTGCGACGCGTCGTGCATCGTGCTCGATGCGGTGCGCTATCCGTCGTTCCTGCGGCTCGACGCGGGCACGGGCCGCTTCG
CCGACAACCCGGTCGGCGAGCTGTGGCGCTACGTGATCGATACGGCGAACGGGCTGATCGACGAAGGGCCGCTCGCCGAT
GGCGGCATCGAGATGCCGCGCATCAACGAAAGCCGGACGGGGCGCCGCTACCGCTACCTGTATGCGGTCGAGCAGCCGAA
CAACGCGGAAATGCGCGGCGTGATGCGCTTCGACCACGCGAGCGGCACGACCACGCGCTACGCGTTGCCGCCCGGCGACC
AGAACAGCGAGCCGGTGTTCGTGCCGCGCCCGGGCGGCGTCGACGAGGACGACGGCTGGCTGCTGGTGGTGGTCTACCGC
GCGGCGACGGATACGAGCGACGTCGTGATCCTCGATGCGCGGGCGATCGACGCGGGGCCGGTCGCGACCGTGCACCTGCC
GCGCCGCGTGCCGGCCGGGTTCCACGGCGCGTGGGTGCCGCGCGAGCACTGA

Upstream 100 bases:

>100_bases
TCGCCGGCTGGCCGGACGACGTGCGCGACCATGCGCTCGCGCTGGCGCGCGGCGAGCTGCCGCCGTCCACCGAAGACTGC
TGAAAGGAGCATCGGACGTC

Downstream 100 bases:

>100_bases
GCGGCGGGGCGGCGCGTCACTGTGCGCGCAGCGCGTCGACGATCTTCAGCCGCGCGGCGCGCATCGCCGGCAGGAACCCG
CCGACCAGCCCCATCACGAG

Product: retinal pigment epithelial membrane protein

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MTALDLNRGAIAPVADEIDLVDLRVTGAIPHELAGTLLRNGPNPPGGRFEGSDMLSWWPEAAMLHAIAFEGGRATGYRNR
WARTQRWAAVHAPEAASQLPDTNPNVNVLQHAGELLALSEGGAPFAITAALDSLGIPARHAGLGGGMTAHPKVDPVTGEL
IAFRADWRAPWLRYGVADAQGVQRVDLEIDLSAPSMMHDLAITETRSLLLDLNVGYDFSLLKLGHRMPLRWHDDRPARIG
VIPRHGGAVRWFGVEPCFILHVVNAYDCDASCIVLDAVRYPSFLRLDAGTGRFADNPVGELWRYVIDTANGLIDEGPLAD
GGIEMPRINESRTGRRYRYLYAVEQPNNAEMRGVMRFDHASGTTTRYALPPGDQNSEPVFVPRPGGVDEDDGWLLVVVYR
AATDTSDVVILDARAIDAGPVATVHLPRRVPAGFHGAWVPREH

Sequences:

>Translated_443_residues
MTALDLNRGAIAPVADEIDLVDLRVTGAIPHELAGTLLRNGPNPPGGRFEGSDMLSWWPEAAMLHAIAFEGGRATGYRNR
WARTQRWAAVHAPEAASQLPDTNPNVNVLQHAGELLALSEGGAPFAITAALDSLGIPARHAGLGGGMTAHPKVDPVTGEL
IAFRADWRAPWLRYGVADAQGVQRVDLEIDLSAPSMMHDLAITETRSLLLDLNVGYDFSLLKLGHRMPLRWHDDRPARIG
VIPRHGGAVRWFGVEPCFILHVVNAYDCDASCIVLDAVRYPSFLRLDAGTGRFADNPVGELWRYVIDTANGLIDEGPLAD
GGIEMPRINESRTGRRYRYLYAVEQPNNAEMRGVMRFDHASGTTTRYALPPGDQNSEPVFVPRPGGVDEDDGWLLVVVYR
AATDTSDVVILDARAIDAGPVATVHLPRRVPAGFHGAWVPREH
>Mature_442_residues
TALDLNRGAIAPVADEIDLVDLRVTGAIPHELAGTLLRNGPNPPGGRFEGSDMLSWWPEAAMLHAIAFEGGRATGYRNRW
ARTQRWAAVHAPEAASQLPDTNPNVNVLQHAGELLALSEGGAPFAITAALDSLGIPARHAGLGGGMTAHPKVDPVTGELI
AFRADWRAPWLRYGVADAQGVQRVDLEIDLSAPSMMHDLAITETRSLLLDLNVGYDFSLLKLGHRMPLRWHDDRPARIGV
IPRHGGAVRWFGVEPCFILHVVNAYDCDASCIVLDAVRYPSFLRLDAGTGRFADNPVGELWRYVIDTANGLIDEGPLADG
GIEMPRINESRTGRRYRYLYAVEQPNNAEMRGVMRFDHASGTTTRYALPPGDQNSEPVFVPRPGGVDEDDGWLLVVVYRA
ATDTSDVVILDARAIDAGPVATVHLPRRVPAGFHGAWVPREH

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 48254; Mature: 48123

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALDLNRGAIAPVADEIDLVDLRVTGAIPHELAGTLLRNGPNPPGGRFEGSDMLSWWPE
CCEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCHH
AAMLHAIAFEGGRATGYRNRWARTQRWAAVHAPEAASQLPDTNPNVNVLQHAGELLALSE
HHEEEEEEECCCCCCCCHHHHHHHHHEEEEECCHHHHHCCCCCCCHHHHCCCCCEEEEEC
GGAPFAITAALDSLGIPARHAGLGGGMTAHPKVDPVTGELIAFRADWRAPWLRYGVADAQ
CCCCEEEEEEHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCC
GVQRVDLEIDLSAPSMMHDLAITETRSLLLDLNVGYDFSLLKLGHRMPLRWHDDRPARIG
CCEEEEEEEECCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCCCCCEECCCCCCEEE
VIPRHGGAVRWFGVEPCFILHVVNAYDCDASCIVLDAVRYPSFLRLDAGTGRFADNPVGE
EEECCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHH
LWRYVIDTANGLIDEGPLADGGIEMPRINESRTGRRYRYLYAVEQPNNAEMRGVMRFDHA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEECC
SGTTTRYALPPGDQNSEPVFVPRPGGVDEDDGWLLVVVYRAATDTSDVVILDARAIDAGP
CCCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCC
VATVHLPRRVPAGFHGAWVPREH
EEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TALDLNRGAIAPVADEIDLVDLRVTGAIPHELAGTLLRNGPNPPGGRFEGSDMLSWWPE
CEEECCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCHH
AAMLHAIAFEGGRATGYRNRWARTQRWAAVHAPEAASQLPDTNPNVNVLQHAGELLALSE
HHEEEEEEECCCCCCCCHHHHHHHHHEEEEECCHHHHHCCCCCCCHHHHCCCCCEEEEEC
GGAPFAITAALDSLGIPARHAGLGGGMTAHPKVDPVTGELIAFRADWRAPWLRYGVADAQ
CCCCEEEEEEHHHCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHCCCCCCC
GVQRVDLEIDLSAPSMMHDLAITETRSLLLDLNVGYDFSLLKLGHRMPLRWHDDRPARIG
CCEEEEEEEECCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCCCCCEECCCCCCEEE
VIPRHGGAVRWFGVEPCFILHVVNAYDCDASCIVLDAVRYPSFLRLDAGTGRFADNPVGE
EEECCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHH
LWRYVIDTANGLIDEGPLADGGIEMPRINESRTGRRYRYLYAVEQPNNAEMRGVMRFDHA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCEEEEEEEECC
SGTTTRYALPPGDQNSEPVFVPRPGGVDEDDGWLLVVVYRAATDTSDVVILDARAIDAGP
CCCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCC
VATVHLPRRVPAGFHGAWVPREH
EEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]