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The map label for this gene is ahcY [H]

Identifier: 78064852

GI number: 78064852

Start: 233937

End: 235355

Strand: Direct

Name: ahcY [H]

Synonym: Bcep18194_A3375

Alternate gene names: 78064852

Gene position: 233937-235355 (Clockwise)

Preceding gene: 78064851

Following gene: 78064853

Centisome position: 6.33

GC content: 63.64

Gene sequence:

>1419_bases
ATGAACGCCATTATCGATTCCAAAGCTTCCAACGATTACGTCGTCGCCGACATGGCGCTGGCCGGCTGGGGCCGCAAGGA
ACTGAACATCGCCGAGACCGAAATGCCGGGCCTCGTGCAGATCCGTGACGAATACAAGGCACAGCAGCCGCTGAAGGGCG
CGCGCATTGCCGGTTCGCTGCACATGACGATCCAGACGGGCGTGCTGATCGAGACGCTGAAGGCGCTCGGCGCGGACGTC
CGCTGGGCCTCGTGCAACATCTTCTCGACGCAGGACCACGCCGCTGCCGCGATCGTCGAAGCCGGCACGCCGGTGTTCGC
GTTCAAGGGCGAATCGCTCGACGAATACTGGGAATTCTCGCACCGCATCTTCGAATGGCCGAACGGCGAATTCGCGAACA
TGATCCTGGACGACGGCGGCGACGCAACGCTGCTGCTGATCCTCGGCGCGAAGGCCGAGAAGGACCGTTCGGTGATCGCG
AAGCCGACCAACGAGGAAGAAGTCGCGCTGTACAAGTCGATCGCGCAGCACCTCGACGCGGACCCGACCTGGTACTCGAC
GCGCCTCGCGCACATCAAGGGCGTGACCGAAGAAACCACGACCGGCGTGCACCGCCTGTACCAGATGGAAAAGGACGGCC
GCCTGCCGTTCCCGGCGTTCAACGTGAACGATTCGGTCACGAAGTCGAAGTTCGACAACCTGTACGGCTGCCGTGAATCG
CTGGTCGACGGCATCAAGCGCGCGACCGACGTGATGATCGCGGGCAAGGTCGCGGTCGTCGCGGGCTACGGCGACGTGGG
CAAGGGCTGCGCGCAATCGCTGCGCGGCCTGGGCGCCACCGTGTGGGTCACCGAAATCGACCCGATCTGCGCACTGCAGG
CGGCGATGGAAGGCTACCGCGTCGTGACGATGGAATACGCAGCCGACAAGGCCGACATCTTCGTGACGGCCACGGGCAAC
TTCCACGTGATCGGCCACGATCACATGAAGGCGATGCGCCACAACGCGATCGTCTGCAACATCGGTCACTTCGACTCGGA
AATCGACGTCGCGTCGACCCGCCAGTACCAGTGGGAAAACATCAAGCCGCAGGTCGACCACATCATCTTCCCGGACGGCA
AGCGCGTGATCCTGCTGGCGGAAGGCCGCCTCGTGAACCTCGGCTGCGCGACCGGCCACCCGTCGTTCGTGATGTCGAAC
TCGTTCGCGAACCAGACGCTCGCGCAGATCGAGCTGTTCGTGCGCGGCAACGAGTACGAGAACAAGGTGTACGTGCTGCC
GAAGCACCTCGATGAAAAGGTCGCACGCCTGCACCTGGCGCGCATCGGCGCGAACCTGTCCGTGCTGTCGGACGAGCAGG
CTTCGTACATCGGCGTGCAGAAGGACGGCCCGTTCAAGCCGAACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
AGGCTTCACCAAGCAGCTTGTGCGGCACAACCGCGTCGGCCCCGCTTCCTGAACGGCGCTCACGTCACCAATCTAGAAAC
TTTTTAGAAAGGAGGGCGTG

Downstream 100 bases:

>100_bases
TCCGACGCGCCGCTGCCGCGGTGCCGTGCGCGCGTCGCCGACGCGTACCCGGCATGGCGGCACGGCGCGCCGGATCGCCG
GCTGCCGCGGCGCGCCTTCG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MNAIIDSKASNDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIA
KPTNEEEVALYKSIAQHLDADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGN
FHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFVRGNEYENKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY

Sequences:

>Translated_472_residues
MNAIIDSKASNDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIA
KPTNEEEVALYKSIAQHLDADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGN
FHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFVRGNEYENKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY
>Mature_472_residues
MNAIIDSKASNDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIA
KPTNEEEVALYKSIAQHLDADPTWYSTRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGN
FHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFVRGNEYENKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.0909090909091, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=58.6363636363636, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=50, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=50, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=50, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=50, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI21361647, Length=470, Percent_Identity=49.7872340425532, Blast_Score=455, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=59.5698924731183, Blast_Score=523, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320882, Length=483, Percent_Identity=56.935817805383, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=58.8744588744589, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24656245, Length=471, Percent_Identity=50.5307855626327, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=49.4669509594883, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=49.3589743589744, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52063; Mature: 52063

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIIDSKASNDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSL
CCCCCCCCCCCCEEEEEEEECCCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECEE
HMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFS
EEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHH
HRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIAKPTNEEEVALYKSIAQHLDA
HHEEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DPTWYSTRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYR
HHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEE
VVTMEYAADKADIFVTATGNFHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWEN
EEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECCC
IKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFVRGNEYE
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHEEEEEEEEECCCCC
NKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY
CEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MNAIIDSKASNDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSL
CCCCCCCCCCCCEEEEEEEECCCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECEE
HMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFS
EEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHHH
HRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIAKPTNEEEVALYKSIAQHLDA
HHEEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DPTWYSTRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYR
HHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEE
VVTMEYAADKADIFVTATGNFHVIGHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWEN
EEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECCC
IKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFVRGNEYE
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHEEEEEEEEECCCCC
NKVYVLPKHLDEKVARLHLARIGANLSVLSDEQASYIGVQKDGPFKPNHYRY
CEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA