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The map label for this gene is aqpZ [H]

Identifier: 78064827

GI number: 78064827

Start: 207551

End: 208294

Strand: Reverse

Name: aqpZ [H]

Synonym: Bcep18194_A3350

Alternate gene names: 78064827

Gene position: 208294-207551 (Counterclockwise)

Preceding gene: 78064829

Following gene: 78064824

Centisome position: 5.64

GC content: 66.94

Gene sequence:

>744_bases
ATGAATCTTTCTCAGCGTCTCGCTGCAGAGGTATTCGGCACGTTCTGGCTGGTGCTCGGCGGGTGCGGAAGCGCCGTGCT
GGCCGCCGCCTTTCCGGGCCTCGGCATCGGCTTTGCCGGCGTCGCACTTGCCTTCGGCCTGACTGTGCTGACGATGGCAT
TCGCAATCGGCCACATTTCGGGCTGCCACCTGAATCCGGCGGTGAGCGTCGGCCTGACGGTCGCCGGCCGCTTTCCTGCC
CGCGATCTCGTGCCGTACATCGTCGCGCAGGTGGTCGGTGCGACGCTCGGCGCATTCGTGCTGTACCTGATCGCGACCGG
CAAGCCGGGCTTTGACGTCGTCGGCAGCGGTTTTGCGACGAACGGCTTCGGCGAGCGCTCGCCGGGCCACTACTCGCTCA
GCGCGTCGTTCATTTGCGAAGTCGTGATGACGGGCTTCTTCCTGTTCGTGATCCTGGGCGCCACCGACAAGCGCGGCGTG
CCGGCCGGCTTTGCGCCGATCGCGATCGGCCTGTGCCTGACGCTGATCCACCTGATCTCGATTCCGGTCACCAACACGTC
GGTGAACCCGGCCCGCTCGACCGGCCCCGCGCTGTTCGTGGGCGGCGACGCGATCGGCCAGCTCTGGCTGTTCTGGGTGG
CACCGATCATCGGCGCGGTACTCGCCGGGATCATCTATCCGCTGGTCGCGGGGCGTGACGACGCCGTCGACCTGCTGCCG
GCATCGGCTCGCACAAGCGAATAA

Upstream 100 bases:

>100_bases
CGACCCGATTCATTTCCTATAATCCAGACCAATTCCGGGTGACGGTTTAAATCCGTCACGTCGTCCGGTTGTCTTCAATC
CACTTGACCAAGGTCCTTAC

Downstream 100 bases:

>100_bases
AACACTACGGGGTCAAGCGAGCAGAGCAGCGAGCCTCACGCTGTCAAAGAAGATCGAGGCAGGTAATTTCGACGGGCGCC
ACTGGCGCCCGTTTTTCATT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLVPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFATNGFGERSPGHYSLSASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPIIGAVLAGIIYPLVAGRDDAVDLLP
ASARTSE

Sequences:

>Translated_247_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLVPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFATNGFGERSPGHYSLSASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPIIGAVLAGIIYPLVAGRDDAVDLLP
ASARTSE
>Mature_247_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLVPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFATNGFGERSPGHYSLSASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPIIGAVLAGIIYPLVAGRDDAVDLLP
ASARTSE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502181, Length=190, Percent_Identity=39.4736842105263, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4755125, Length=190, Percent_Identity=39.4736842105263, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4502183, Length=219, Percent_Identity=36.0730593607306, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI37694062, Length=190, Percent_Identity=36.3157894736842, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4502179, Length=227, Percent_Identity=33.0396475770925, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI6912506, Length=219, Percent_Identity=33.7899543378995, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI157266307, Length=245, Percent_Identity=31.0204081632653, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI22538420, Length=271, Percent_Identity=30.2583025830258, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI86792455, Length=231, Percent_Identity=32.034632034632, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI4826645, Length=248, Percent_Identity=31.8548387096774, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4502187, Length=242, Percent_Identity=29.7520661157025, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI45446752, Length=209, Percent_Identity=29.1866028708134, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=70.6730769230769, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1790362, Length=268, Percent_Identity=29.1044776119403, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71992966, Length=262, Percent_Identity=29.7709923664122, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71993722, Length=243, Percent_Identity=30.8641975308642, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17558372, Length=209, Percent_Identity=30.1435406698565, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992961, Length=261, Percent_Identity=29.1187739463602, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=252, Percent_Identity=30.5555555555556, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=252, Percent_Identity=30.5555555555556, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994009, Length=238, Percent_Identity=27.3109243697479, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17544068, Length=259, Percent_Identity=28.957528957529, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=201, Percent_Identity=27.363184079602, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24652747, Length=240, Percent_Identity=35.8333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45551084, Length=240, Percent_Identity=35.8333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24652751, Length=234, Percent_Identity=32.0512820512821, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922038, Length=234, Percent_Identity=32.0512820512821, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24762342, Length=211, Percent_Identity=28.9099526066351, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550503, Length=245, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24762346, Length=227, Percent_Identity=29.5154185022026, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24762348, Length=227, Percent_Identity=29.5154185022026, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130305, Length=227, Percent_Identity=29.5154185022026, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24762344, Length=227, Percent_Identity=29.5154185022026, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136672, Length=225, Percent_Identity=27.1111111111111, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25150; Mature: 25150

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSVGLTVAGRFPARDLVPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFAT
CCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
NGFGERSPGHYSLSASFICEVVMTGFFLFVILGATDKRGVPAGFAPIAIGLCLTLIHLIS
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPIIGAVLAGIIYPLVAGRDDAVDLLP
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
ASARTSE
CCCCCCC
>Mature Secondary Structure
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSVGLTVAGRFPARDLVPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFAT
CCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
NGFGERSPGHYSLSASFICEVVMTGFFLFVILGATDKRGVPAGFAPIAIGLCLTLIHLIS
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPIIGAVLAGIIYPLVAGRDDAVDLLP
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
ASARTSE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]