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The map label for this gene is ilvG [H]

Identifier: 78064795

GI number: 78064795

Start: 163338

End: 165041

Strand: Reverse

Name: ilvG [H]

Synonym: Bcep18194_A3318

Alternate gene names: 78064795

Gene position: 165041-163338 (Counterclockwise)

Preceding gene: 78064798

Following gene: 78064794

Centisome position: 4.47

GC content: 71.13

Gene sequence:

>1704_bases
ATGTCGCATTCCAAGGATCTCGAGCAGCCCGCCACCACCGGCGCGCGACTGCTCGTCGATGCGTTGCTCGCCAATCACGT
CGAACGCGTGTTCTGCGTGCCGGGCGAGAGTTTCCTCGCCGTACTCGATGCGCTCGCGGACGACACCGCCCGCATCCAGA
CGGTCGTCTGCCGCCACGAGGCGGCCGCCGCGAACATGGCCGAGGCCGTCGGCAAGCTGACCGGCCGCCCCGGCATCGCA
TTCGTCACGCGCGGGCCCGGCGCGACCCATGCGTCGATCGGCGTGCACACCGCGTTCCAGGATTCGACGCCGATGATCCT
GTTCGTCGGCCAGTGCGCGCGCGAGCACCTCGACCGCGAAGCCTTCCAGGAAATCGACTACCGGCGGATGTTCGGCCAGA
TGGCGAAATGGGTCGCGCAGATCGACGACCCGCGCCGCATTCCCGAATACCTGAGCCATGCGTTCCACGTCGCGACGTCC
GGCAGGCCCGGCCCGGTCGTGCTCGCGCTGCCGGAAGACGTGCTGTCCGAAGCATGCGCGCCGCAGCCCGTCGTGCCGGC
CGCGAAGCGCGTCGCGGCCGCGCCGTCGGCCGCGCAGCTCGACGAGTTGCGCGAGCGGCTCGCGCGCGCGGAACGGCCGT
TCGCGATCGTCGGCGGCAGCGGCTGGACGCCCGACGCGTGCGCGAACCTGCGCACCTTCGTCGAGCGCTGGCAGTTGCCG
GTGGCCTGCGCATTCCGCTACCAGGACACGATCGACAACGCGCACCCGAACTACGCGGGCGACGTCGGGCTCGGGATCAA
CCCCGCGCTCGGGAAGCGCATCCGCGACGCCGACCTGCTGCTCGTGATCGGGCCGCGCCTCGGCGAAGCGACGACCGGCG
GCTACACGCTGCTCGACATCCCGAAGACGCGCCAGACGCTGATCCACGTGCACCAGGGCGCGGACGAGCTCGGCCGTGTG
TATGCGGCCGACCTGCCGATCGTGTCGGGCATGCCCGAGATCGCCGCGCCGCTCGCCGCGCTCGAGGCGCCCGAGCACCC
GGCGTGGGCCGGCACGGCTGCCGACGCGCATCGTGCGTATCGCGAATGGCATGCGCCGCTGCCGATGCCCGGCGACGTCC
AGCTCGGCGACGTGATGGTGCAGCTGCGCGAGCGCCTGCCGCATGACGCGATCCTCACCAACGGCGCCGGCAACTATGCG
ATCTGGCTGCATCGCCACTTCGCGTACCGGCACTTCCGCTCGCAGCTCGCGCCGACCAGCGGCGCGATGGGCTACGGCGT
GCCAGCCGCGCTTGCCGCGAAGTCGCTGTACCCGTCGCGCGCCGTCGTCGCGCTCGCGGGCGATGGCTGCTTCATGATGG
CCGGCAACGAGCTCGCGACCGCGATGCAGTACGGGCTGAACATCGTCGTGATCGTCGTCAACAACGGGCATTTCGGCACG
ATCCGCATGCATCAGGAGCGCAACTACCCGGGACGCGTGCACGGCACGGGGCTCACGAATCCCGATTTCGCCGCGTATGC
GCGCGCGTTCGGCGCGCATGGCGAGACCGTCGAGCGCACCGCCGATTTCGCGCCCGCGCTCGAACGCGCGCTGACCTGCG
GGCTGCCCGCGCTGATCGAGATCCGTATTCCGCAGGACGCCAGCACGCCGGCCGCGACGCTCGAGCAGATCCGCGAACAG
GGCCGCCGCGCACGCGGCGGATGA

Upstream 100 bases:

>100_bases
TGAATCCCTACGTGTTCCGACACTTTTCAGCGGCCGGCGTACCGGCGCCCCGTCAACGGGCGTAAGCTGTACGTCCCGCT
ACCCAGGGAGACGGCAGCCC

Downstream 100 bases:

>100_bases
CGGTGGACACGCACGCCGCGCCGCCCGACGTCGCACTGTCGCACGACGACGCACTCACGCTCCCCGGCACGCTGCTCGCA
CCGGACGGCACGCTCGTCGC

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MSHSKDLEQPATTGARLLVDALLANHVERVFCVPGESFLAVLDALADDTARIQTVVCRHEAAAANMAEAVGKLTGRPGIA
FVTRGPGATHASIGVHTAFQDSTPMILFVGQCAREHLDREAFQEIDYRRMFGQMAKWVAQIDDPRRIPEYLSHAFHVATS
GRPGPVVLALPEDVLSEACAPQPVVPAAKRVAAAPSAAQLDELRERLARAERPFAIVGGSGWTPDACANLRTFVERWQLP
VACAFRYQDTIDNAHPNYAGDVGLGINPALGKRIRDADLLLVIGPRLGEATTGGYTLLDIPKTRQTLIHVHQGADELGRV
YAADLPIVSGMPEIAAPLAALEAPEHPAWAGTAADAHRAYREWHAPLPMPGDVQLGDVMVQLRERLPHDAILTNGAGNYA
IWLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPSRAVVALAGDGCFMMAGNELATAMQYGLNIVVIVVNNGHFGT
IRMHQERNYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFAPALERALTCGLPALIEIRIPQDASTPAATLEQIREQ
GRRARGG

Sequences:

>Translated_567_residues
MSHSKDLEQPATTGARLLVDALLANHVERVFCVPGESFLAVLDALADDTARIQTVVCRHEAAAANMAEAVGKLTGRPGIA
FVTRGPGATHASIGVHTAFQDSTPMILFVGQCAREHLDREAFQEIDYRRMFGQMAKWVAQIDDPRRIPEYLSHAFHVATS
GRPGPVVLALPEDVLSEACAPQPVVPAAKRVAAAPSAAQLDELRERLARAERPFAIVGGSGWTPDACANLRTFVERWQLP
VACAFRYQDTIDNAHPNYAGDVGLGINPALGKRIRDADLLLVIGPRLGEATTGGYTLLDIPKTRQTLIHVHQGADELGRV
YAADLPIVSGMPEIAAPLAALEAPEHPAWAGTAADAHRAYREWHAPLPMPGDVQLGDVMVQLRERLPHDAILTNGAGNYA
IWLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPSRAVVALAGDGCFMMAGNELATAMQYGLNIVVIVVNNGHFGT
IRMHQERNYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFAPALERALTCGLPALIEIRIPQDASTPAATLEQIREQ
GRRARGG
>Mature_566_residues
SHSKDLEQPATTGARLLVDALLANHVERVFCVPGESFLAVLDALADDTARIQTVVCRHEAAAANMAEAVGKLTGRPGIAF
VTRGPGATHASIGVHTAFQDSTPMILFVGQCAREHLDREAFQEIDYRRMFGQMAKWVAQIDDPRRIPEYLSHAFHVATSG
RPGPVVLALPEDVLSEACAPQPVVPAAKRVAAAPSAAQLDELRERLARAERPFAIVGGSGWTPDACANLRTFVERWQLPV
ACAFRYQDTIDNAHPNYAGDVGLGINPALGKRIRDADLLLVIGPRLGEATTGGYTLLDIPKTRQTLIHVHQGADELGRVY
AADLPIVSGMPEIAAPLAALEAPEHPAWAGTAADAHRAYREWHAPLPMPGDVQLGDVMVQLRERLPHDAILTNGAGNYAI
WLHRHFAYRHFRSQLAPTSGAMGYGVPAALAAKSLYPSRAVVALAGDGCFMMAGNELATAMQYGLNIVVIVVNNGHFGTI
RMHQERNYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFAPALERALTCGLPALIEIRIPQDASTPAATLEQIREQG
RRARGG

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=587, Percent_Identity=24.0204429301533, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI21361361, Length=551, Percent_Identity=25.0453720508167, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI87081685, Length=534, Percent_Identity=29.2134831460674, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1790104, Length=550, Percent_Identity=28.5454545454545, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786717, Length=536, Percent_Identity=28.544776119403, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1787096, Length=563, Percent_Identity=25.2220248667851, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788716, Length=583, Percent_Identity=25.3859348198971, Blast_Score=108, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17542570, Length=577, Percent_Identity=24.6100519930676, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17531301, Length=568, Percent_Identity=26.5845070422535, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17531299, Length=568, Percent_Identity=26.5845070422535, Blast_Score=115, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=557, Percent_Identity=25.1346499102334, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320816, Length=545, Percent_Identity=21.1009174311927, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922626, Length=483, Percent_Identity=26.0869565217391, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60986; Mature: 60855

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSKDLEQPATTGARLLVDALLANHVERVFCVPGESFLAVLDALADDTARIQTVVCRHE
CCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHH
AAAANMAEAVGKLTGRPGIAFVTRGPGATHASIGVHTAFQDSTPMILFVGQCAREHLDRE
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHH
AFQEIDYRRMFGQMAKWVAQIDDPRRIPEYLSHAFHVATSGRPGPVVLALPEDVLSEACA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCEEEECCHHHHHHHCC
PQPVVPAAKRVAAAPSAAQLDELRERLARAERPFAIVGGSGWTPDACANLRTFVERWQLP
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCC
VACAFRYQDTIDNAHPNYAGDVGLGINPALGKRIRDADLLLVIGPRLGEATTGGYTLLDI
CEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEC
PKTRQTLIHVHQGADELGRVYAADLPIVSGMPEIAAPLAALEAPEHPAWAGTAADAHRAY
CCHHHHHHHHHCCHHHHHHEEECCCCHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
REWHAPLPMPGDVQLGDVMVQLRERLPHDAILTNGAGNYAIWLHRHFAYRHFRSQLAPTS
HHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCEEEEEHHHHHHHHHHHHCCCCC
GAMGYGVPAALAAKSLYPSRAVVALAGDGCFMMAGNELATAMQYGLNIVVIVVNNGHFGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHCCCEEEEEEEECCCEEE
IRMHQERNYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFAPALERALTCGLPALIE
EEEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
IRIPQDASTPAATLEQIREQGRRARGG
EECCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHSKDLEQPATTGARLLVDALLANHVERVFCVPGESFLAVLDALADDTARIQTVVCRHE
CCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHH
AAAANMAEAVGKLTGRPGIAFVTRGPGATHASIGVHTAFQDSTPMILFVGQCAREHLDRE
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHH
AFQEIDYRRMFGQMAKWVAQIDDPRRIPEYLSHAFHVATSGRPGPVVLALPEDVLSEACA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCCCCEEEECCHHHHHHHCC
PQPVVPAAKRVAAAPSAAQLDELRERLARAERPFAIVGGSGWTPDACANLRTFVERWQLP
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCC
VACAFRYQDTIDNAHPNYAGDVGLGINPALGKRIRDADLLLVIGPRLGEATTGGYTLLDI
CEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEC
PKTRQTLIHVHQGADELGRVYAADLPIVSGMPEIAAPLAALEAPEHPAWAGTAADAHRAY
CCHHHHHHHHHCCHHHHHHEEECCCCHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
REWHAPLPMPGDVQLGDVMVQLRERLPHDAILTNGAGNYAIWLHRHFAYRHFRSQLAPTS
HHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCEEEEEHHHHHHHHHHHHCCCCC
GAMGYGVPAALAAKSLYPSRAVVALAGDGCFMMAGNELATAMQYGLNIVVIVVNNGHFGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECHHHHHHHHCCCEEEEEEEECCCEEE
IRMHQERNYPGRVHGTGLTNPDFAAYARAFGAHGETVERTADFAPALERALTCGLPALIE
EEEECCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
IRIPQDASTPAATLEQIREQGRRARGG
EECCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]