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The map label for this gene is hemE

Identifier: 78064769

GI number: 78064769

Start: 126709

End: 127887

Strand: Direct

Name: hemE

Synonym: Bcep18194_A3292

Alternate gene names: 78064769

Gene position: 126709-127887 (Clockwise)

Preceding gene: 78064767

Following gene: 78064770

Centisome position: 3.43

GC content: 68.62

Gene sequence:

>1179_bases
ATGGCCGCCATCGCGTCGGCAAGCGCAGCCCGACGGCGGCTGTCCGGTAAAATGCCGCTTTGCCCTCGCATCGTCGCTCC
TACCGTGGCCCATACCCTGCTTAACGACACCTTCCTGCGTGCGCTTCTGCGCGAGCCGACCGACTACACGCCGATCTGGC
TGATGCGCCAGGCCGGCCGCTACCTGCCCGAATACAACGCGACGCGCGCGCGCGCCGGCAGCTTCCTCGGTCTCGCGAAG
AATCCCGACTACGCGACCGAAGTGACGCTGCAGCCGCTCGAGCGCTTTCCGCTCGACGCCGCGATCCTGTTCTCTGACAT
CCTGACGATTCCGGACGCGATGGGGCTCGGCCTCGACTTCCAGGTCGGCGAAGGGCCGAAGTTTGCGCATCCGGTGCGTA
CCGAGGCCGACGTCGCGAAGCTCGCGGTGCCGGACATCGAAGAGACGCTCGGCTACGTAACGGGCGCCGTGCGCGAGATC
CGCCGCGCGCTCACCGACGGCCAGGGCCGCCAGCGCGTGCCGCTGATCGGCTTTTCGGGCAGCCCGTGGACGCTCGCGTG
CTACATGGTCGAAGGCGGCGGGTCGGACGATTTCCGCACGGTGAAGTCGATGGCGTATTCGCGCCCCGACCTGATGCACC
GGATCCTCGACGTGAACGCGCAGGCGGTGGCCGCGTACCTGAACGCGCAGATCGAAGCGGGCGCGCAGGCCGTGATGATC
TTCGATACGTGGGGCGGCGCGCTGGCGGACGGCGCGTACCAGCGCTTCTCGCTGGACTACATCCGCCGCGTCGTCTCGCA
GCTCAAGCGCGAGCACGACGGCGAGCGCGTGCCGGTGATCACGTTCACCAAGGGCGGCGGGCTGTGGCTCGAGGAGATCG
CGGCGACCGGCGTCGACGCGGTCGGGCTCGACTGGACCGTCAACCTCGGCAAGGCGCGCGAGCGCGTCGCGGGCAAGGTC
GCGCTGCAGGGCAACCTCGACCCGACGATCCTGTTTGCGCCGCCGGCTGCAGTACGCGAGCAGGCGCGCGCGGTGCTCGA
CAGCTACGGCAATCATCCGGGCCACGTCTTCAACCTCGGGCACGGCATTTCGCAGTTTACGTCGCCCGATCACGTCGCCG
AACTCGTCGACGAAGTGCATAGCCACAGCCGCGCGATTCGTAGCGGAGCCGCTGGCTGA

Upstream 100 bases:

>100_bases
AGCGCGGTGGCGGCGAGCGTGGCGAGTGTCTTCATCGGTCTCCTCCTTCGTTTCGTTCGATATGAGCGTCCGATCATAAC
GGAGCCATCGCGCGCGTCAT

Downstream 100 bases:

>100_bases
ACGCAAGCGCTGTCATGCTGCACTGCGGCGTGACAGCGTTTCGCTGCCGGCACTAAACAGGGCGCAACCCCGCACCGGTT
GCCGATTCAGTGCTTGTCAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAAIASASAARRRLSGKMPLCPRIVAPTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAK
NPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREI
RRALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVAGKV
ALQGNLDPTILFAPPAAVREQARAVLDSYGNHPGHVFNLGHGISQFTSPDHVAELVDEVHSHSRAIRSGAAG

Sequences:

>Translated_392_residues
MAAIASASAARRRLSGKMPLCPRIVAPTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAK
NPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREI
RRALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVAGKV
ALQGNLDPTILFAPPAAVREQARAVLDSYGNHPGHVFNLGHGISQFTSPDHVAELVDEVHSHSRAIRSGAAG
>Mature_391_residues
AAIASASAARRRLSGKMPLCPRIVAPTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKN
PDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFQVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREIR
RALTDGQGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIF
DTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDAVGLDWTVNLGKARERVAGKVA
LQGNLDPTILFAPPAAVREQARAVLDSYGNHPGHVFNLGHGISQFTSPDHVAELVDEVHSHSRAIRSGAAG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=360, Percent_Identity=47.5, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=61.8233618233618, Blast_Score=448, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6320252, Length=355, Percent_Identity=36.3380281690141, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI19921920, Length=353, Percent_Identity=37.6770538243626, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=37.6770538243626, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 42438; Mature: 42307

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIASASAARRRLSGKMPLCPRIVAPTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGR
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YLPEYNATRARAGSFLGLAKNPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDF
CCCCCCCHHHHCCCEEECCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEE
QVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREIRRALTDGQGRQRVPLIGFSG
EECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
SPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
CCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEE
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDA
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCE
VGLDWTVNLGKARERVAGKVALQGNLDPTILFAPPAAVREQARAVLDSYGNHPGHVFNLG
ECCCEEEECHHHHHHHHCEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEECC
HGISQFTSPDHVAELVDEVHSHSRAIRSGAAG
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAIASASAARRRLSGKMPLCPRIVAPTVAHTLLNDTFLRALLREPTDYTPIWLMRQAGR
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
YLPEYNATRARAGSFLGLAKNPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDF
CCCCCCCHHHHCCCEEECCCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHCCHHHCCCCEE
QVGEGPKFAHPVRTEADVAKLAVPDIEETLGYVTGAVREIRRALTDGQGRQRVPLIGFSG
EECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCC
SPWTLACYMVEGGGSDDFRTVKSMAYSRPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMI
CCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEE
FDTWGGALADGAYQRFSLDYIRRVVSQLKREHDGERVPVITFTKGGGLWLEEIAATGVDA
EECCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCE
VGLDWTVNLGKARERVAGKVALQGNLDPTILFAPPAAVREQARAVLDSYGNHPGHVFNLG
ECCCEEEECHHHHHHHHCEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEECC
HGISQFTSPDHVAELVDEVHSHSRAIRSGAAG
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA