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The map label for this gene is phhA

Identifier: 78064736

GI number: 78064736

Start: 92403

End: 93323

Strand: Reverse

Name: phhA

Synonym: Bcep18194_A3259

Alternate gene names: 78064736

Gene position: 93323-92403 (Counterclockwise)

Preceding gene: 78064738

Following gene: 78064735

Centisome position: 2.53

GC content: 67.75

Gene sequence:

>921_bases
ATGGTTCCCAACCGCCACGTGCAGAGCCAGATCATGTCCACCGTCGTCACCGCGAAACTGCAAGAGCAGTTCGATGCGGG
CCTCGAAACCCGCGCCGATTTCACCATCGACCAGCCGCTCGCGCGTTACGGCCAGGTCGACCACGCGGTGTGGAAGCAGC
TCTATGCACGCCAGTCGGCGCTGCTGCGCGGGCGCGCGTGCGACGCATTCGTCGCGGGGCTCGGGAAGATCGACCTGCCG
GCCGATCGCGTGCCGTCGTTCGCCGACGTGAACCGCCAGTTGAAGCCGGCAACGGGCTGGGAAATCGTCGCGGTGCCGGG
CCTCGTGCCCGACCGCGTGTTCTTCGAGCATCTCGCGAACCGGCGCTTCCCCGTCACCTGGTGGATGCGCCGCCCCGACC
AGCTCGACTACCTGCAGGAACCCGACTGCTTCCACGACCTGTTCGGCCACGTGCCGCTGCTGATCAACCCGGTGTTCGCC
GACTACATGCAGGCGTACGGCCGCACCGCGCTCGCGGTCGCCGACGACGAAGCGGCGCTGGCGCGCCTCGCGCGGCTCTA
CTGGTATACGGTGGAATTCGGGCTGATCCGCGATCCGCGCGGCACGAACGGGTTGTCGATCTACGGTGCCGGGATCGTGT
CGAGCAAGGGCGAAAGCCTGTACAGCCTCGAAAGCGCGGCGCCGAACCGGCTCGGCTTCGACCTCGAGCGCGTGATGCGC
ACGAAGTACCGGATCGACACGTTCCAGAAGACCTACTTCGTGATCGACGATTTCGCGCAGCTGTTCGCGCTCGCCGATGT
CGACGGCCGTGCACTGGCCGACCGGCTGGCAGCGCTGCCCGAGTTCGCGGCCGGCGCGGTGCTCGATACCGATCGCGTGC
TGCATCGCGGCACGGGCGAAGGCTGGTCCGCCGACGCATGA

Upstream 100 bases:

>100_bases
TCCCCGCATTGATTCGTGATTTGATGCGCGATTATCGCATCATCTAGCGAATCATCGCCAATATTGCGCCCATTCCGCGC
GCAGCCCGCTCTACACTTGC

Downstream 100 bases:

>100_bases
CGTTCGAGGGTGCCGGAACGCGCCTCTGCCGATCGCCATCCCCCGGATGGCCGTCCCACAACTATGAAACAATGACCGGT
GCCGGCTTCGCCGCGCGGCG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MVPNRHVQSQIMSTVVTAKLQEQFDAGLETRADFTIDQPLARYGQVDHAVWKQLYARQSALLRGRACDAFVAGLGKIDLP
ADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLINPVFA
DYMQAYGRTALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAPNRLGFDLERVMR
TKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGEGWSADA

Sequences:

>Translated_306_residues
MVPNRHVQSQIMSTVVTAKLQEQFDAGLETRADFTIDQPLARYGQVDHAVWKQLYARQSALLRGRACDAFVAGLGKIDLP
ADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLINPVFA
DYMQAYGRTALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAPNRLGFDLERVMR
TKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGEGWSADA
>Mature_306_residues
MVPNRHVQSQIMSTVVTAKLQEQFDAGLETRADFTIDQPLARYGQVDHAVWKQLYARQSALLRGRACDAFVAGLGKIDLP
ADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLINPVFA
DYMQAYGRTALAVADDEAALARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAPNRLGFDLERVMR
TKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGEGWSADA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=226, Percent_Identity=35.8407079646018, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI88900501, Length=226, Percent_Identity=35.8407079646018, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI88900505, Length=226, Percent_Identity=35.8407079646018, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557819, Length=227, Percent_Identity=32.5991189427313, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI31795563, Length=229, Percent_Identity=32.7510917030568, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4759248, Length=224, Percent_Identity=32.5892857142857, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71980736, Length=218, Percent_Identity=33.9449541284404, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=230, Percent_Identity=35.2173913043478, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI115533973, Length=236, Percent_Identity=30.9322033898305, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI115532103, Length=236, Percent_Identity=30.9322033898305, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71980731, Length=150, Percent_Identity=32.6666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=33.9285714285714, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=33.9285714285714, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24654994, Length=180, Percent_Identity=37.2222222222222, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17136776, Length=224, Percent_Identity=29.9107142857143, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17136774, Length=224, Percent_Identity=29.9107142857143, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 34256; Mature: 34256

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPNRHVQSQIMSTVVTAKLQEQFDAGLETRADFTIDQPLARYGQVDHAVWKQLYARQSA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHH
LLRGRACDAFVAGLGKIDLPADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLAN
HHHCCCHHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHC
RRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLINPVFADYMQAYGRTALAVADDEAAL
CCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHH
ARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAPNRLGFDLERVMR
HHHHHHHHHHHEEEEEECCCCCCCEEEEECCEECCCCCCHHHHHHCCCCCCCCCHHHHHH
TKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCC
GWSADA
CCCCCC
>Mature Secondary Structure
MVPNRHVQSQIMSTVVTAKLQEQFDAGLETRADFTIDQPLARYGQVDHAVWKQLYARQSA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHH
LLRGRACDAFVAGLGKIDLPADRVPSFADVNRQLKPATGWEIVAVPGLVPDRVFFEHLAN
HHHCCCHHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHC
RRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLINPVFADYMQAYGRTALAVADDEAAL
CCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHH
ARLARLYWYTVEFGLIRDPRGTNGLSIYGAGIVSSKGESLYSLESAAPNRLGFDLERVMR
HHHHHHHHHHHEEEEEECCCCCCCEEEEECCEECCCCCCHHHHHHCCCCCCCCCHHHHHH
TKYRIDTFQKTYFVIDDFAQLFALADVDGRALADRLAALPEFAAGAVLDTDRVLHRGTGE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCC
GWSADA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]