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The map label for this gene is exuT [H]

Identifier: 78049917

GI number: 78049917

Start: 5014904

End: 5016217

Strand: Reverse

Name: exuT [H]

Synonym: XCV4361

Alternate gene names: 78049917

Gene position: 5016217-5014904 (Counterclockwise)

Preceding gene: 78049922

Following gene: 78049916

Centisome position: 96.87

GC content: 65.22

Gene sequence:

>1314_bases
ATGAGCGAGGTGCCCGCCGCGGCCCCGGGGGCCGCAACGGCAAGGCTCGGCCGGGTGCGTTGGCGGGTCTGCGCCCTGCT
GCTAGCCGCCACCACCATCAACTATGTGGACCGCCAGGTACTGGGCGTGCTGGCGCCGTTCCTGCAGACGCAGATCGGTT
GGAACGAAATCCAGTACGGCTATATCGTCACCGCATTCCAGGCGGCGTATGCGCTGGGCTTGCTGTGCAGCGGTGCGGTG
ATCGACCGCTTCGGCACTCGGCTCGGCTATGCGCTGGCGATCGGCCTGTGGAGCCTGGCGGCGATGGGGCATGCCTTGGC
CACCAGCGTGGTGGGGTTTGCGATTGCGCGGTTTTTCCTGGGCCTTGGCGAATCGGGCAATTTTCCTGCAGCGCTCAAGA
CGGTGGCCGAATGGTTCCCGCGCCGTGAGCGCGCGCTGGCCACCGGCATCTTCAATTCCGGCTCCAATATCGGGGCCATT
GTTGCCCCATTGTTGGTGCCGTTGATTGCCACCGCCTGGGGCTGGCAGGCGGCATTCCTGTTCACCGGCGTGCTCAGTGC
AACCTGGTTGGCGGTGTGGTGGTTCAGCTATCACCCGCCCGAGCAACAACCCCGGTTGTCTGCTGCAGAACTGGCGCACA
TCCGCAGCGATGCGCATGAGCCGGTGCAGCGCCGGCTGTCGTGGCTACAGGTGCTTCGGCATCGGCAAGCCTGGGCGTTT
GTGCTGGGCAAGTTCATCACCGACCCGATCTGGTGGTTCTTCCTGTTCTGGCTGCCGAAGTTCCTGCACGCCGAATATGG
CCTGAGTCTGCTGCAATTGGGCGTGCCCTTGATCGTGATCTTCGTGCTGGCCGACATCGGCAGCATTGCCGGTGGTTGGG
TGGCCGGGCGTTTCATCGCACGTGGCTGGAGCGTCAACCGCGCACGCAAGACCGCGATGCTGATCTGCGCGATTTCCGTC
GTGCCCATCGTCTTTGCCGCACGCGCCGACAACCTGTGGCTGGCGGTCGCGCTGATCGGGCTGGCCACCGCCGCCCATCA
GGGCTGGTCGGCGAATCTGTTTACGCTGCCTTCGGACATGTTTCCGCGCCACGCGGTTGCCACGGTGGTGGGCATCGGCG
GTTTTGCCGGTGCGGTGGGCGGCATGCTGATCGCCACCTTCATCGGCTTTCTGTTGCAAGCCACCGGCAGCTATGTGCCG
GTGTTTCTGATGGCAGGCTCTGCCTATCTGCTGGCCTTGGCCGTCGTGCACACGCTGGTGCCGCGGCTGGAGCCGGCGCA
GTTGCCTGCCGATCCAGCGCCGACATCGTCCTGA

Upstream 100 bases:

>100_bases
GCGACGGACCCGATCGGCACCTGATGGGTGCACGCTTGCAGGACATCGGCCAATCCGCGCAGGAAGCCGGCGCGCTGGCG
CGCCCGCATAGGCCACGCGC

Downstream 100 bases:

>100_bases
GGTGAGCCTATGCACAAGCGCGCAGTAGCACTGGGGTTATTGATGGTGGCCGGCATGGCCGCGCCAACCCACGCGGCACC
GCTGGCAGCGGCGGCGTCCA

Product: anion:cation symporter family protein

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSEVPAAAPGAATARLGRVRWRVCALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIVTAFQAAYALGLLCSGAV
IDRFGTRLGYALAIGLWSLAAMGHALATSVVGFAIARFFLGLGESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAI
VAPLLVPLIATAWGWQAAFLFTGVLSATWLAVWWFSYHPPEQQPRLSAAELAHIRSDAHEPVQRRLSWLQVLRHRQAWAF
VLGKFITDPIWWFFLFWLPKFLHAEYGLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGWSVNRARKTAMLICAISV
VPIVFAARADNLWLAVALIGLATAAHQGWSANLFTLPSDMFPRHAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVP
VFLMAGSAYLLALAVVHTLVPRLEPAQLPADPAPTSS

Sequences:

>Translated_437_residues
MSEVPAAAPGAATARLGRVRWRVCALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIVTAFQAAYALGLLCSGAV
IDRFGTRLGYALAIGLWSLAAMGHALATSVVGFAIARFFLGLGESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAI
VAPLLVPLIATAWGWQAAFLFTGVLSATWLAVWWFSYHPPEQQPRLSAAELAHIRSDAHEPVQRRLSWLQVLRHRQAWAF
VLGKFITDPIWWFFLFWLPKFLHAEYGLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGWSVNRARKTAMLICAISV
VPIVFAARADNLWLAVALIGLATAAHQGWSANLFTLPSDMFPRHAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVP
VFLMAGSAYLLALAVVHTLVPRLEPAQLPADPAPTSS
>Mature_436_residues
SEVPAAAPGAATARLGRVRWRVCALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYGYIVTAFQAAYALGLLCSGAVI
DRFGTRLGYALAIGLWSLAAMGHALATSVVGFAIARFFLGLGESGNFPAALKTVAEWFPRRERALATGIFNSGSNIGAIV
APLLVPLIATAWGWQAAFLFTGVLSATWLAVWWFSYHPPEQQPRLSAAELAHIRSDAHEPVQRRLSWLQVLRHRQAWAFV
LGKFITDPIWWFFLFWLPKFLHAEYGLSLLQLGVPLIVIFVLADIGSIAGGWVAGRFIARGWSVNRARKTAMLICAISVV
PIVFAARADNLWLAVALIGLATAAHQGWSANLFTLPSDMFPRHAVATVVGIGGFAGAVGGMLIATFIGFLLQATGSYVPV
FLMAGSAYLLALAVVHTLVPRLEPAQLPADPAPTSS

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=381, Percent_Identity=25.4593175853018, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI21322234, Length=407, Percent_Identity=23.0958230958231, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI6912666, Length=342, Percent_Identity=24.2690058479532, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI148743791, Length=329, Percent_Identity=22.4924012158055, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI2367193, Length=430, Percent_Identity=33.953488372093, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87082320, Length=396, Percent_Identity=30.5555555555556, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789515, Length=431, Percent_Identity=28.3062645011601, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1789152, Length=448, Percent_Identity=26.1160714285714, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI2367379, Length=414, Percent_Identity=26.0869565217391, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI87082231, Length=223, Percent_Identity=26.9058295964126, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082404, Length=347, Percent_Identity=24.4956772334294, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082071, Length=420, Percent_Identity=23.5714285714286, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115533556, Length=399, Percent_Identity=25.5639097744361, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533554, Length=399, Percent_Identity=25.5639097744361, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535049, Length=450, Percent_Identity=21.7777777777778, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17552542, Length=290, Percent_Identity=28.9655172413793, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI32565914, Length=382, Percent_Identity=22.2513089005236, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71991448, Length=405, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71991453, Length=405, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32565916, Length=247, Percent_Identity=25.5060728744939, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17560030, Length=216, Percent_Identity=23.6111111111111, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193205400, Length=235, Percent_Identity=25.1063829787234, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17566884, Length=198, Percent_Identity=24.7474747474747, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583789, Length=397, Percent_Identity=24.4332493702771, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24584153, Length=393, Percent_Identity=22.9007633587786, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920686, Length=388, Percent_Identity=22.1649484536082, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648416, Length=368, Percent_Identity=24.1847826086957, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356189, Length=368, Percent_Identity=24.1847826086957, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24580790, Length=295, Percent_Identity=23.728813559322, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639764, Length=336, Percent_Identity=25.8928571428571, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641682, Length=386, Percent_Identity=22.7979274611399, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI62484226, Length=341, Percent_Identity=24.3401759530792, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28573708, Length=384, Percent_Identity=24.21875, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573707, Length=384, Percent_Identity=24.21875, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573299, Length=241, Percent_Identity=25.7261410788382, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47028; Mature: 46896

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEVPAAAPGAATARLGRVRWRVCALLLAATTINYVDRQVLGVLAPFLQTQIGWNEIQYG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH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CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]