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The map label for this gene is nrdF [H]

Identifier: 78049716

GI number: 78049716

Start: 4757455

End: 4758498

Strand: Reverse

Name: nrdF [H]

Synonym: XCV4160

Alternate gene names: 78049716

Gene position: 4758498-4757455 (Counterclockwise)

Preceding gene: 78049717

Following gene: 78049715

Centisome position: 91.89

GC content: 58.43

Gene sequence:

>1044_bases
ATGTCCGCAACACCGCTCGACCGCATCAAGATCCTTGAGCCGCGCAACCCGAACCGTTCGACCGGCATCATCAACGGCCA
GACCTCGGGCATCCTCAACTGGAACGATATTCCGTACCCGTCCTTCTATCGGGCCTACAAGGAACTGTCGACCAACTTCT
GGATCCCCGACGAGGTGGACATGAAGGGCGATGCGCGCCAGTACAACGAGCTGTCGGCGCGCGAAAAGAATGCCTACGAT
TCGATCATCGGCTTGCTGGCCACGCTGGATTCGCCGCAGACGCGCTTCATCTACAACGTGGCCGAATACATCACCGACCC
GGCCGCGCATGCCAATGCGGCGATCATCGGCCAGCAGGAAGTGATTCATAACGAGAGCTACAGCTACGTGCTGGCTTCGA
TCACCGGCCTGGCCGACCAGAACCGCGTATTCGAAATCGCGCGCACGCACCCGACCATCATCAAGCGCAACGCGCCGATC
ATGGGCGCCTACGAAGACTTCATGCGCGAGAAGACGGCCGAAACGCTGATCCGTTCGCTGATCCAGTCCTCGATCCTGGA
AGGCATCAACTTCTATTCCGGCTTTGCGTATTTCTACAATCTGGTCCGCCAGAACCGCATGACCGGCACCGGCAAGATCA
TCAGCTTCATCAACCGCGACGAACTGGCGCATACGAAGTTCATCAGCGAATTGATTCGCGCCATCATCGGCGAGAACCAG
GCGCTGCAGGGCGACGAGCTCACCGACTACGTGCACAAGGCCTTCGAGCACGCGATCGACCTGGAAACCCAGTGGACCGC
CGAAGTGCTGGACGGCATCGACGGCATCGACGTGGATGAGATGATCCGCTACGTGAAGTACCGCGCCAACAAGATGGCCG
GCATGCTCGGCATCGAGAAGCTGTACGAAGGCGCCAACGACAACGTGATGCCGTGGATCAAGGCCTACGCCGACAACTTC
ACCGAGACCAAGACCGACTTCTTCGAGATGCGCAATGCCTCGTACAAGAAGACCAATTCGGATAACGGCTTCGACGACTT
GTAA

Upstream 100 bases:

>100_bases
TTCGGCGCGCCCCCTGACTCAGGGGGCTTTCCTCCAGATTGATTTGTTGCGCCGCCGTTTTTGTTTGTACGCGCGGCGCC
TGAAACACGAGTAGAAACCC

Downstream 100 bases:

>100_bases
AGCGCTGCAAAAAAGAACCCGCCACTGTGGGCGGGTTCTAGATTGATCTTTTACAACTTAGTTGATTCAGATCAAACGAG
TGGCTACTGTGCGCGCTAAC

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSATPLDRIKILEPRNPNRSTGIINGQTSGILNWNDIPYPSFYRAYKELSTNFWIPDEVDMKGDARQYNELSAREKNAYD
SIIGLLATLDSPQTRFIYNVAEYITDPAAHANAAIIGQQEVIHNESYSYVLASITGLADQNRVFEIARTHPTIIKRNAPI
MGAYEDFMREKTAETLIRSLIQSSILEGINFYSGFAYFYNLVRQNRMTGTGKIISFINRDELAHTKFISELIRAIIGENQ
ALQGDELTDYVHKAFEHAIDLETQWTAEVLDGIDGIDVDEMIRYVKYRANKMAGMLGIEKLYEGANDNVMPWIKAYADNF
TETKTDFFEMRNASYKKTNSDNGFDDL

Sequences:

>Translated_347_residues
MSATPLDRIKILEPRNPNRSTGIINGQTSGILNWNDIPYPSFYRAYKELSTNFWIPDEVDMKGDARQYNELSAREKNAYD
SIIGLLATLDSPQTRFIYNVAEYITDPAAHANAAIIGQQEVIHNESYSYVLASITGLADQNRVFEIARTHPTIIKRNAPI
MGAYEDFMREKTAETLIRSLIQSSILEGINFYSGFAYFYNLVRQNRMTGTGKIISFINRDELAHTKFISELIRAIIGENQ
ALQGDELTDYVHKAFEHAIDLETQWTAEVLDGIDGIDVDEMIRYVKYRANKMAGMLGIEKLYEGANDNVMPWIKAYADNF
TETKTDFFEMRNASYKKTNSDNGFDDL
>Mature_346_residues
SATPLDRIKILEPRNPNRSTGIINGQTSGILNWNDIPYPSFYRAYKELSTNFWIPDEVDMKGDARQYNELSAREKNAYDS
IIGLLATLDSPQTRFIYNVAEYITDPAAHANAAIIGQQEVIHNESYSYVLASITGLADQNRVFEIARTHPTIIKRNAPIM
GAYEDFMREKTAETLIRSLIQSSILEGINFYSGFAYFYNLVRQNRMTGTGKIISFINRDELAHTKFISELIRAIIGENQA
LQGDELTDYVHKAFEHAIDLETQWTAEVLDGIDGIDVDEMIRYVKYRANKMAGMLGIEKLYEGANDNVMPWIKAYADNFT
ETKTDFFEMRNASYKKTNSDNGFDDL

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=305, Percent_Identity=23.2786885245902, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI289177074, Length=305, Percent_Identity=23.2786885245902, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557845, Length=305, Percent_Identity=21.9672131147541, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI260064013, Length=305, Percent_Identity=21.9672131147541, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI289177076, Length=285, Percent_Identity=22.8070175438596, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789031, Length=307, Percent_Identity=24.1042345276873, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788567, Length=336, Percent_Identity=25, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17551968, Length=309, Percent_Identity=24.9190938511327, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322434, Length=308, Percent_Identity=24.025974025974, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18079279, Length=305, Percent_Identity=22.6229508196721, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 39535; Mature: 39404

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATPLDRIKILEPRNPNRSTGIINGQTSGILNWNDIPYPSFYRAYKELSTNFWIPDEVD
CCCCCCCCEEEECCCCCCCCCCEECCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
MKGDARQYNELSAREKNAYDSIIGLLATLDSPQTRFIYNVAEYITDPAAHANAAIIGQQE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHCCEEEECHHH
VIHNESYSYVLASITGLADQNRVFEIARTHPTIIKRNAPIMGAYEDFMREKTAETLIRSL
HHHCCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH
IQSSILEGINFYSGFAYFYNLVRQNRMTGTGKIISFINRDELAHTKFISELIRAIIGENQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ALQGDELTDYVHKAFEHAIDLETQWTAEVLDGIDGIDVDEMIRYVKYRANKMAGMLGIEK
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LYEGANDNVMPWIKAYADNFTETKTDFFEMRNASYKKTNSDNGFDDL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SATPLDRIKILEPRNPNRSTGIINGQTSGILNWNDIPYPSFYRAYKELSTNFWIPDEVD
CCCCCCCEEEECCCCCCCCCCEECCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
MKGDARQYNELSAREKNAYDSIIGLLATLDSPQTRFIYNVAEYITDPAAHANAAIIGQQE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHCCEEEECHHH
VIHNESYSYVLASITGLADQNRVFEIARTHPTIIKRNAPIMGAYEDFMREKTAETLIRSL
HHHCCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHH
IQSSILEGINFYSGFAYFYNLVRQNRMTGTGKIISFINRDELAHTKFISELIRAIIGENQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ALQGDELTDYVHKAFEHAIDLETQWTAEVLDGIDGIDVDEMIRYVKYRANKMAGMLGIEK
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LYEGANDNVMPWIKAYADNFTETKTDFFEMRNASYKKTNSDNGFDDL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]