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The map label for this gene is ctaB [H]

Identifier: 78049553

GI number: 78049553

Start: 4588168

End: 4589064

Strand: Reverse

Name: ctaB [H]

Synonym: XCV3997

Alternate gene names: 78049553

Gene position: 4589064-4588168 (Counterclockwise)

Preceding gene: 78049554

Following gene: 78049546

Centisome position: 88.62

GC content: 63.66

Gene sequence:

>897_bases
ATGGCTGTCAGCGCACGCGATTATTGGGATCTGACCAAACCCAAGGTGGTGGCACTGATCGTGTTCACCGCGTTGGTGGG
CATGTTCCTGGCCATTCCCGACATGCCGACCTGGCTGCAGGTACGCACCGGCGCGCTGGGCTTCCTGGGTATCTGGCTGG
CGGCTTCAGCGGCGGCAGCGATCAACCAACTGCTCGACGCCAAGATCGACGCACAGATGGCGCGCACCTCATGGCGCCCG
CTGGTGGTGGGCAAGGTGCGGCCCTGGCAGGTGCTGGTGTTCGCCGGCGCGCTGATCGTGATCTCCATGACCATTCTGGT
GGTGTGGGTGAATGTCATCACCGCGGTGCTGACCTTCGCCTCGCTGATCGGGTACGCGGTGATTTACACCGTGTACCTGA
AGCGTGCGACCTCGCAGAACATCGTGATTGGCGGCCTGGCCGGCGCCACCCCGCCGATGCTGGGCTGGGCCGCGGTGACC
GGGCTGCCGACCAGCGCCGACTGGATCAATGCCTCGCTGCTGGTGCTGATCATCTTCATCTGGACGCCGCCGCATTTCTG
GGCGCTGGCGATCTTCCGCCGTGCCGATTACGCCAAGGCCGCGATCCCGATGTTGCCGGTGACCCATGGCGTGCCGCATA
CGCGCAAGCAGATCCTGGTGTACACCGTATTGCTGGCGATCGTGACCTTGGCGCCGGTGGCGGTGGGCATGAGCGGGGTG
TTCTATCTGGGCGGTGCGATCGTGCTCAATGCGGTGTTCCTCTGGTACGCGTGGCGCATGCTGAACCCGCCGGACGAACT
GTTTTCGATGAAGATGTTCGGGTACTCCATCGTGTACCTGATGGCGTTGTTCGCCTTCCTGATGGTCGACCATCTGCTGC
TGCCGTGGGTGCGCTAG

Upstream 100 bases:

>100_bases
CGCTGCCGCTGGAGGTCTCGGTCATGCATAACGGCGGGGCGGTGGCGTTGCTGTTCGTGCTGGTCTCGCTGCTGGCGCGG
CTGCGCGCGCCGGAGTGAGC

Downstream 100 bases:

>100_bases
TCGCCGAAGCGAGACGAGCGGCAATGCGGTAGCTCTGCCCCGATGACTTGCGTGGCAATCAGGCGGATGGATGGATCACG
CCTGCAGCGCCTGCAGCGCG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAAINQLLDAKIDAQMARTSWRP
LVVGKVRPWQVLVFAGALIVISMTILVVWVNVITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVT
GLPTSADWINASLLVLIIFIWTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGV
FYLGGAIVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR

Sequences:

>Translated_298_residues
MAVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAAINQLLDAKIDAQMARTSWRP
LVVGKVRPWQVLVFAGALIVISMTILVVWVNVITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVT
GLPTSADWINASLLVLIIFIWTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGV
FYLGGAIVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR
>Mature_297_residues
AVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAAINQLLDAKIDAQMARTSWRPL
VVGKVRPWQVLVFAGALIVISMTILVVWVNVITAVLTFASLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVTG
LPTSADWINASLLVLIIFIWTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGVF
YLGGAIVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=201, Percent_Identity=38.3084577114428, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786631, Length=295, Percent_Identity=31.1864406779661, Blast_Score=130, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71998235, Length=272, Percent_Identity=31.25, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6325085, Length=197, Percent_Identity=33.502538071066, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921064, Length=286, Percent_Identity=32.1678321678322, Blast_Score=124, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 32716; Mature: 32585

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
INQLLDAKIDAQMARTSWRPLVVGKVRPWQVLVFAGALIVISMTILVVWVNVITAVLTFA
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVTGLPTSADWINASLLVLIIFI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
WTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGV
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLGGAIVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVSARDYWDLTKPKVVALIVFTALVGMFLAIPDMPTWLQVRTGALGFLGIWLAASAAAA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHH
INQLLDAKIDAQMARTSWRPLVVGKVRPWQVLVFAGALIVISMTILVVWVNVITAVLTFA
HHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIGYAVIYTVYLKRATSQNIVIGGLAGATPPMLGWAAVTGLPTSADWINASLLVLIIFI
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHH
WTPPHFWALAIFRRADYAKAAIPMLPVTHGVPHTRKQILVYTVLLAIVTLAPVAVGMSGV
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYLGGAIVLNAVFLWYAWRMLNPPDELFSMKMFGYSIVYLMALFAFLMVDHLLLPWVR
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]