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The map label for this gene is ung [H]

Identifier: 78049506

GI number: 78049506

Start: 4534060

End: 4534785

Strand: Reverse

Name: ung [H]

Synonym: XCV3950

Alternate gene names: 78049506

Gene position: 4534785-4534060 (Counterclockwise)

Preceding gene: 78049507

Following gene: 78049505

Centisome position: 87.57

GC content: 66.94

Gene sequence:

>726_bases
ATGACTGAAGGGGAGGGACGCATCCAGCTGGAACCGTCGTGGAAGGCAAGAGTGGGCGACTGGCTGCTGCGCCCGCAGAT
GCAGGAGCTGTCGGCATTCCTGCGCCAGCGCAAGGCGGCCGGAGCACGGGTGTTTCCGCCCGGCCCGCAGATCTTCGCCG
CCTTCGACGCCACCCCGTTCGAACAGGTCAAGGTGGTGATCCTGGGCCAGGACCCGTATCACGGCGAAGGTCAGGCGCAT
GGGCTGTGCTTCTCGGTATTGCCCGGCGTGCCGGTGCCGCCGTCGCTGCTCAACATCTACAAGGAGATCCAGGACGACCT
GGGGATCGCGCGGCCGGATCACGGCTACCTGATGCCCTGGGCGCGCCAGGGCGTGCTGCTGCTCAATGCCGTGCTGACGG
TGGAGCAGGGGCGCGCCGGCGCCCACCAGAACAAGGGCTGGGAAGGCTTCACCGATCATGTGGTGGACACCCTCAACCGC
GAGCGCGAAGGGCTGGTGTTTCTGCTGTGGGGCAGCTATGCGCAGTCCAAGGGCAAGGTCATCGACCAGGCACGCCATCG
GGTCTTGAAGGCGCCGCATCCTTCGCCGCTTTCGGCGCACCGCGGCTTCCTGGGCTGCCGGCATTTTTCCAAGACCAACG
ACCATTTGCGGCGGCGTGGTCTGAGCCCGATCGACTGGTCGCTGCCACCGCGCAGCGCACTGGACACCACCTCCACCGGC
GCCTGA

Upstream 100 bases:

>100_bases
CCAACGATCTGGTGCAGAAACCGATCGAAGAGCGCCTGCTGGTGACCAAGGTGTTGTTCCAGCTGCGCCTGGCACGCCTG
GAGGATCAGGCTGTCACGCT

Downstream 100 bases:

>100_bases
ACGACGCTGCGGCATCCTGGTGCGCAACCAATTTGTCACGGTTTGCACAGGGGCTTGGTGATACCGTAAGCTTCGAATTT
GGGGTGCCGGGCTGTAGAAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTEGEGRIQLEPSWKARVGDWLLRPQMQELSAFLRQRKAAGARVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGEGQAH
GLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVDTLNR
EREGLVFLLWGSYAQSKGKVIDQARHRVLKAPHPSPLSAHRGFLGCRHFSKTNDHLRRRGLSPIDWSLPPRSALDTTSTG
A

Sequences:

>Translated_241_residues
MTEGEGRIQLEPSWKARVGDWLLRPQMQELSAFLRQRKAAGARVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGEGQAH
GLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVDTLNR
EREGLVFLLWGSYAQSKGKVIDQARHRVLKAPHPSPLSAHRGFLGCRHFSKTNDHLRRRGLSPIDWSLPPRSALDTTSTG
A
>Mature_240_residues
TEGEGRIQLEPSWKARVGDWLLRPQMQELSAFLRQRKAAGARVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGEGQAHG
LCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVDTLNRE
REGLVFLLWGSYAQSKGKVIDQARHRVLKAPHPSPLSAHRGFLGCRHFSKTNDHLRRRGLSPIDWSLPPRSALDTTSTGA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=55.3488372093023, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=55.3488372093023, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=55.7603686635945, Blast_Score=254, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=47.926267281106, Blast_Score=217, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=242, Percent_Identity=44.6280991735537, Blast_Score=182, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26743; Mature: 26612

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEGEGRIQLEPSWKARVGDWLLRPQMQELSAFLRQRKAAGARVFPPGPQIFAAFDATPF
CCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCH
EQVKVVILGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPW
HHEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
ARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVDTLNREREGLVFLLWGSYAQSKGKV
HHCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
IDQARHRVLKAPHPSPLSAHRGFLGCRHFSKTNDHLRRRGLSPIDWSLPPRSALDTTSTG
HHHHHHHHHCCCCCCCCHHHCCHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
A
C
>Mature Secondary Structure 
TEGEGRIQLEPSWKARVGDWLLRPQMQELSAFLRQRKAAGARVFPPGPQIFAAFDATPF
CCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCH
EQVKVVILGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPW
HHEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
ARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVDTLNREREGLVFLLWGSYAQSKGKV
HHCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
IDQARHRVLKAPHPSPLSAHRGFLGCRHFSKTNDHLRRRGLSPIDWSLPPRSALDTTSTG
HHHHHHHHHCCCCCCCCHHHCCHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]