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The map label for this gene is dtd [H]

Identifier: 78049469

GI number: 78049469

Start: 4492883

End: 4493323

Strand: Reverse

Name: dtd [H]

Synonym: XCV3913

Alternate gene names: 78049469

Gene position: 4493323-4492883 (Counterclockwise)

Preceding gene: 78049471

Following gene: 78049468

Centisome position: 86.77

GC content: 66.67

Gene sequence:

>441_bases
ATGCTTGCACTGATCCAGCGCGTCACCCGCGCCGCCGTCACGGTCGATGACCAGATCGTCGGGCAGATCGGCCCCGGGCT
GCTGGCGCTGATCGGCGTGGAGCCCGGCGACAGCGACGCGCAGATCCGGCGCCTGGCCGAGCGGCTGCTGAGCTACCGGG
TATTCGGCGACGACGCCGGCAAGATGAACCGCTCACTCACCGATACCGGCGGCGGCCTGCTGCTGGTCAGCCAGTTCACC
CTGGCTGCGGACACCAGTTCCGGCAACCGCCCAGGCTTCAGCACCGCCGCGCCACCACTGGAGGCTGAACCGGCGTTCAA
TCAATTGGTGGCGATCTGCCGCGAAAAACATCGCGGTGGGGTGGAAGCCGGGCGTTTTGGTGCCCATATGGTTGTCGACC
TGGTCAACGATGGCCCGGTGACCTTCCTTCTCAGACCCTAG

Upstream 100 bases:

>100_bases
CGGCGCAATTCTAAACAGCGCAGACCACGAAGGCCCGCGCGTGACAGTGCCGGCAGCGCTGGGCATGCTGCGCGGCACAG
TTTGCCGCCCGAGAATGCCC

Downstream 100 bases:

>100_bases
ATACACCACGTCCACCAGCGGTCCCGTCTTGAATCCGGCAGACCGGGCTTCACGCTGGTATAATGCTAGGTTCTCTTTCC
AATCTCAAAGCCGGTGGCGC

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MLALIQRVTRAAVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAGKMNRSLTDTGGGLLLVSQFT
LAADTSSGNRPGFSTAAPPLEAEPAFNQLVAICREKHRGGVEAGRFGAHMVVDLVNDGPVTFLLRP

Sequences:

>Translated_146_residues
MLALIQRVTRAAVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAGKMNRSLTDTGGGLLLVSQFT
LAADTSSGNRPGFSTAAPPLEAEPAFNQLVAICREKHRGGVEAGRFGAHMVVDLVNDGPVTFLLRP
>Mature_146_residues
MLALIQRVTRAAVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAGKMNRSLTDTGGGLLLVSQFT
LAADTSSGNRPGFSTAAPPLEAEPAFNQLVAICREKHRGGVEAGRFGAHMVVDLVNDGPVTFLLRP

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine [H]

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family [H]

Homologues:

Organism=Homo sapiens, GI30795227, Length=146, Percent_Identity=39.041095890411, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=53.7931034482759, Blast_Score=157, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI115533292, Length=143, Percent_Identity=39.1608391608392, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6319982, Length=146, Percent_Identity=34.2465753424658, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281361569, Length=145, Percent_Identity=38.6206896551724, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003732 [H]

Pfam domain/function: PF02580 Tyr_Deacylase [H]

EC number: NA

Molecular weight: Translated: 15424; Mature: 15424

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALIQRVTRAAVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAG
CHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCH
KMNRSLTDTGGGLLLVSQFTLAADTSSGNRPGFSTAAPPLEAEPAFNQLVAICREKHRGG
HCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
VEAGRFGAHMVVDLVNDGPVTFLLRP
CCCCCCCCEEEEEEECCCCEEEEECC
>Mature Secondary Structure
MLALIQRVTRAAVTVDDQIVGQIGPGLLALIGVEPGDSDAQIRRLAERLLSYRVFGDDAG
CHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCH
KMNRSLTDTGGGLLLVSQFTLAADTSSGNRPGFSTAAPPLEAEPAFNQLVAICREKHRGG
HCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
VEAGRFGAHMVVDLVNDGPVTFLLRP
CCCCCCCCEEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]