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The map label for this gene is alkB [C]

Identifier: 78049255

GI number: 78049255

Start: 4273811

End: 4274410

Strand: Reverse

Name: alkB [C]

Synonym: XCV3699

Alternate gene names: 78049255

Gene position: 4274410-4273811 (Counterclockwise)

Preceding gene: 78049257

Following gene: 78049250

Centisome position: 82.54

GC content: 66.33

Gene sequence:

>600_bases
ATGAAGATTCGGGTGGCATTGCCGGGGGCGGAGATCAACTGGTGGCGCGGTTGGCTGCCGCCCGCGCAGGCCGATGCGCT
GATGCAGGCGCTGCTGGCGCAGGCGCACTGGGAGGTGCACCGCATCCGGATGTTCGGACGCATGGTGGATTCGCCGCGCC
TGAGCAGCTGGATCGGCGATCCGGAGGCGAGCTATCGCTACTCGGGCACACGGTTCTCGCCACAGCCCTGGCTGGAGGTG
CTGCAGCCCGTGCGCATGCGGCTGGAGGACGAAACCGGTCACCGGTTCAACAGCGTGCTGGTCAATCGCTACCGAAGTGG
CAGCGATGCGATGGGCTGGCACAGCGACGACGAGCCTGAGCTGGGCGCGCAGCCATTGATTGCCTCGGTGAGCCTGGGTG
CGACGCGGCGCTTTGCGTTCAAGCACCGCGACGATGCGGCCCTGAAGCAAATGCTGGAGCTCGGTCACGGCGACCTGTTG
CTGATGGGCGGCGACACCCAGCGCCACTACAAACACGCTTTGCCGCGCACCGCCAAGCCGGTCGACGAGCGCATCAATCT
GACCTTTCGTCAGATCGCGGTGCGCGTGTCCCAGCCATGA

Upstream 100 bases:

>100_bases
GGCTCGATGGCTGTTGCGCATTTTCCGGGATTGCATGTGACGGCGGCAAATCGGGTCGATTCATCCGCGCCATGCCGGGC
TGCGTGCTAGCGTTTCCGGC

Downstream 100 bases:

>100_bases
GCGGCTAGCAACTTGCAGCGCGCTCGCCTGGGCAGTGAGCCCGGTGGGCGTGTCGGCCGCAGCTTGCGTGGGCGCAACCA
GCAATCCAGGTCAAACGATG

Product: DNA repair system specific for alkylated DNA

Products: NA

Alternate protein names: Alkylated DNA Repair Protein; DNA Repair System Specific For Alkylated DNA; DNA-N1-Methyladenine Dioxygenase; 2OG-Fe(II) Oxygenase Superfamily Protein; Oxidoreductase 2OG-Fe(II) Oxygenase Family; 2OG-Fe(II) Oxygenase Family Oxidoreductase; Alkylated DNA Repair Protein-Like Protein; Oxidoreductase 2OG-Fe(II) Oxygenase Family Protein; Alkylated DNA Repair Protein AlkB; CRISPR-Associated Family Protein; DNA Repair System Specific For Alkylated DNA Protein; 2OG-Fe(II) Oxygenase Family Protein; DNA Repair System Protein

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MKIRVALPGAEINWWRGWLPPAQADALMQALLAQAHWEVHRIRMFGRMVDSPRLSSWIGDPEASYRYSGTRFSPQPWLEV
LQPVRMRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPELGAQPLIASVSLGATRRFAFKHRDDAALKQMLELGHGDLL
LMGGDTQRHYKHALPRTAKPVDERINLTFRQIAVRVSQP

Sequences:

>Translated_199_residues
MKIRVALPGAEINWWRGWLPPAQADALMQALLAQAHWEVHRIRMFGRMVDSPRLSSWIGDPEASYRYSGTRFSPQPWLEV
LQPVRMRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPELGAQPLIASVSLGATRRFAFKHRDDAALKQMLELGHGDLL
LMGGDTQRHYKHALPRTAKPVDERINLTFRQIAVRVSQP
>Mature_199_residues
MKIRVALPGAEINWWRGWLPPAQADALMQALLAQAHWEVHRIRMFGRMVDSPRLSSWIGDPEASYRYSGTRFSPQPWLEV
LQPVRMRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPELGAQPLIASVSLGATRRFAFKHRDDAALKQMLELGHGDLL
LMGGDTQRHYKHALPRTAKPVDERINLTFRQIAVRVSQP

Specific function: Probably Involved In The Repair Of Alkylated DNA. Provides Extensive Resistance To Alkylating Agents Such As Mms And Dms (Sn2 Agents), But Not To Mmng And Mnu (Sn1 Agents). [C]

COG id: COG3145

COG function: function code L; Alkylated DNA repair protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI224451107, Length=181, Percent_Identity=39.7790055248619, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI48717226, Length=181, Percent_Identity=39.7790055248619, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI224451103, Length=181, Percent_Identity=39.7790055248619, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI21040275, Length=185, Percent_Identity=37.2972972972973, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 22744; Mature: 22744

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRVALPGAEINWWRGWLPPAQADALMQALLAQAHWEVHRIRMFGRMVDSPRLSSWIGD
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
PEASYRYSGTRFSPQPWLEVLQPVRMRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
LGAQPLIASVSLGATRRFAFKHRDDAALKQMLELGHGDLLLMGGDTQRHYKHALPRTAKP
CCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCCC
VDERINLTFRQIAVRVSQP
HHHHHHHHHHHHEECCCCC
>Mature Secondary Structure
MKIRVALPGAEINWWRGWLPPAQADALMQALLAQAHWEVHRIRMFGRMVDSPRLSSWIGD
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
PEASYRYSGTRFSPQPWLEVLQPVRMRLEDETGHRFNSVLVNRYRSGSDAMGWHSDDEPE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
LGAQPLIASVSLGATRRFAFKHRDDAALKQMLELGHGDLLLMGGDTQRHYKHALPRTAKP
CCCCCHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCCC
VDERINLTFRQIAVRVSQP
HHHHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA