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The map label for this gene is arsC [H]

Identifier: 78049193

GI number: 78049193

Start: 4183715

End: 4184137

Strand: Reverse

Name: arsC [H]

Synonym: XCV3637

Alternate gene names: 78049193

Gene position: 4184137-4183715 (Counterclockwise)

Preceding gene: 78049196

Following gene: 78049192

Centisome position: 80.8

GC content: 65.01

Gene sequence:

>423_bases
ATGCACGCCGTCATCTACCACAATCCCGGTTGCGGAACCTCCCGCAATACCCTTGCCCTGATCCGCCACACCGGCATCGA
ACCGCAGATTGTCGATTACCTGCAGCATCCGCCAAGCCGCCAGACGCTGCAGGCGCTCATCGCCGCTGCCGGCATCACGG
TCCGCCAGGCCATGCGCCAGAAAGGCACGCCCTATCTGGAACTGGGACTGGACGATCCCACCCTGGACGATGCGGCGTTG
TTGAGCGCAATGCTCGCCCATCCGATCCTGATCAACCGCCCATTCGTCCAGACCACGCGCGGCACGCGCCTGTGCCGCCC
CTCCGAATTGGTGCTCGACCTGTTGCCGCCGGCCACGCACGGCTTCATCAAGGAAGACGGCGAACGCGTGCTGGACGAGG
CCGGTCAACGCATTGGCCGCTGA

Upstream 100 bases:

>100_bases
GGCACGCCCGGGCGCCACTCGTACACTGGCCGGTCTGGGCGTCGTTCGGTCATCCGTTGCCGGCGCCGCCATCTACCAGC
CAACCCAGCGCCAGGCCACC

Downstream 100 bases:

>100_bases
CATGTTTGAGCCGGTTCAACCGGCGCCAAGCCGGTGTTGCGCCATCACGCTGGCCGCAGCGCTGGCGATAGATGCAGTGC
GCCTATTCACGGCGCGATGA

Product: arsenate reductase (glutaredoxin)

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MHAVIYHNPGCGTSRNTLALIRHTGIEPQIVDYLQHPPSRQTLQALIAAAGITVRQAMRQKGTPYLELGLDDPTLDDAAL
LSAMLAHPILINRPFVQTTRGTRLCRPSELVLDLLPPATHGFIKEDGERVLDEAGQRIGR

Sequences:

>Translated_140_residues
MHAVIYHNPGCGTSRNTLALIRHTGIEPQIVDYLQHPPSRQTLQALIAAAGITVRQAMRQKGTPYLELGLDDPTLDDAAL
LSAMLAHPILINRPFVQTTRGTRLCRPSELVLDLLPPATHGFIKEDGERVLDEAGQRIGR
>Mature_140_residues
MHAVIYHNPGCGTSRNTLALIRHTGIEPQIVDYLQHPPSRQTLQALIAAAGITVRQAMRQKGTPYLELGLDDPTLDDAAL
LSAMLAHPILINRPFVQTTRGTRLCRPSELVLDLLPPATHGFIKEDGERVLDEAGQRIGR

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=138, Percent_Identity=57.9710144927536, Blast_Score=162, Evalue=5e-42,
Organism=Escherichia coli, GI1788841, Length=112, Percent_Identity=42.8571428571429, Blast_Score=96, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 15375; Mature: 15375

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVIYHNPGCGTSRNTLALIRHTGIEPQIVDYLQHPPSRQTLQALIAAAGITVRQAMRQ
CCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KGTPYLELGLDDPTLDDAALLSAMLAHPILINRPFVQTTRGTRLCRPSELVLDLLPPATH
CCCCEEEECCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
GFIKEDGERVLDEAGQRIGR
CHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHAVIYHNPGCGTSRNTLALIRHTGIEPQIVDYLQHPPSRQTLQALIAAAGITVRQAMRQ
CCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KGTPYLELGLDDPTLDDAALLSAMLAHPILINRPFVQTTRGTRLCRPSELVLDLLPPATH
CCCCEEEECCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCC
GFIKEDGERVLDEAGQRIGR
CHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3021763; 1703401; 1704144 [H]