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The map label for this gene is maeB [H]

Identifier: 78049154

GI number: 78049154

Start: 4134794

End: 4137103

Strand: Reverse

Name: maeB [H]

Synonym: XCV3598

Alternate gene names: 78049154

Gene position: 4137103-4134794 (Counterclockwise)

Preceding gene: 78049155

Following gene: 78049152

Centisome position: 79.89

GC content: 65.54

Gene sequence:

>2310_bases
ATGTCCACCGACGACTTCAAACAGGCCGCCCTCGACTACCACCGCCAGCAGCCGGCCGGCAAGATCAAGGTCACCGCGAC
CAAGCCGATGCTGACCCAGCGCGATCTGTCGCTGGCGTATTCGCCGGGCGTGGCGTTCGCCTGCGAGGCCATCGTCGAAG
ATGCCACCCAGGCCAGCGAGCTCACCGCGCGCGGCAATCTGGTGGCGGTCATCACCAACGGCACGGCGGTGCTGGGCCTG
GGCAACATCGGCCCGCTGGCCTCCAAGCCGGTGATGGAAGGCAAGGGCGTGCTGTTTCAGAAGTTCGCCGGCATCGACGT
GTTCGATATCGAAATCAACGAGAACGACCCGGACAAGCTGGTGGACATCATCGCCAGCCTGGAGCCGACCTTCGGCGGCA
TCAACCTGGAAGACATCAAGGCGCCGGAATGCTTCATCGTCGAGCGCAAGCTGCGCGAGCGCATGAACATCCCGGTGTTC
CACGACGACCAGCACGGCACCGCGATCATCGTTGGCGCCGCCGTGCTCAATGCGCTGGTGGTCACTGGCAAGAAGATCGA
AGAGGTCAAGCTGGCCACCACCGGCATGGGCGCGGCCGGCATTTCCTGCGTCAACATGCTGGTATCGCTGGGCCTGAAGC
CGGAGAACATCCTGGCGCTGGACCGCGATGGCGTGATCCACACCGGCCGCACCGATCTGGACCCGGACAAGCAGCGCTAC
GCCCGCGATACCGACAAGCGCACCCTGGCCGAAATCGTCGAAGGCGCGGACATCTTCCTGGGCCTGTCGGCCGCCGGCAT
CCTCAAGCCGGAGATGGTCGCCAGCATGGCGCGCCAGCCGGTGATCTTCGCGCTGGCCAACCCCAATCCGGAAATCACCC
CGGAAGTGGCCAAGGCGGTGCGCCCGGATTGCATCATCGGCACCGGTCGGTCGGACTATCCGAACCAGATCAACAACGTG
CTGTGCTTCCCGTACCTGTTCCGCGGCGCGCTGGACGTGGGCGCCACCGGCATCAACGAAGAGATGAAGATCGCCTGCGT
CAAGGCGATCGCGGCGATGGCGCGGCGCGAGGCCTCCGACCTGGGTGCGGCCTATGGCGGCGAGACCCCGAGCTTCGGTC
CCGACTACCTGATTCCGCGTCCACTGGACCCGCGCCTGCTGGTGGAACTGTCGTCTGCGGTTGCGCAGGCGGCCATGGAT
TCGGGCGTGGCCACGCGCCCGATCACCGACATGGAGGCCTACCGCGACAAGCTCGGCCAGTTCGTCTACCGCACCAGCCT
GATGATGAAGCCGGTCTACGACCGCGCGCGCGCCGACAAGCAGCGCGTGGTGTATGCCGAGGGCGAAGAAGAAGTGGTGC
TGCGTGCGGTGCAGAACGTGGTCGACGAAGGCCTGGCCTTCCCGATCCTGATCGGCCGCCCGGACGTGATCGAAGCACGC
ATCGAACGCATGGGCCTGCGCCTGACCGCCGGCGTGGATTTCGAGATCACCAACATCCTCGACGACCCCCGCTTCAACGA
TTACTGGCAGTACTACCACGCGCTGACCGAGCGTCGTGGCGTGACCGTCACCGCGGCCAAGGAGCTGATGCGCTCGCGCC
CGACCCTGATCGCGGCAGTGATGGTGGCGCGCGGCGAAGCCGACGCGATGCTGTCCGGCGTGGTCGGCCGCTTCCACAAG
AAGCTGGGCTACGCGCGCAGCGTGATTCCGCTGGAACCGCGGGTGAGCTCCACCTCGGCGATGACTGGTGTCATCAACCA
GCTGGGCGTGTTCTTCTTCCTGGATACGCACGTGCAGGAAGACCCGACGGTGGAGCAGGTGGTGGAAGCCACATTGCAGG
CCGCGTACCGCCTCAAGCTGTTCGGCATCGAGCCGAATATCGCGCTGCTGTCGCACTCCAACTTCGGCAGCCACGACTCG
CGCGATGCGCTGAAGATGCGCCAGGTGCGCGAAGCGCTGCTCAAGCGCAAGCCCGAGCTCAACATCGACGGCGAAATGCA
GGGCGACACCGCCTGGGACGAGGCGCTACGCAAGCAGATCATGCCCAACAGCACCTTGAAGGGCCGCGCCAACCTGTTCG
TGTTGCCGAACCTGGAAGCGGCCAACATCGCCTACAACCTGGTGCGCGTGTTCACCGATGGCGTGGCGATCGGCCCGATC
CTGATGGGCATCTCCAAGCCGGTGCATATCCTCACCACCAGCGCCACCTCGCGCCGGGTGATGAACATGACCGCCATCGC
AGCGGTGGATGCGCAGATCCGCAGGCAGCGCGATGCGGAAAAGGCGGCAGCCGACAAGGGCAGCGACTGA

Upstream 100 bases:

>100_bases
ACCCGTGATTTCCCTGCCGCGCTGACAGCTGCGCGACAGGCCCTTGTTCAGGCAGGAGGGTAGAATTCAGCCTCCTGCGC
CTTCGAGAACCACACCACCG

Downstream 100 bases:

>100_bases
CTCGAGATGTTCAGACTTGCCAGGTCCAAGACTTGGCCGAGTGCTGCTTGATTTGAAGCAGCAAGCGCTCGGCCGGCAAG
ACAACGGCCGATAAGTGTCT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 769; Mature: 768

Protein sequence:

>769_residues
MSTDDFKQAALDYHRQQPAGKIKVTATKPMLTQRDLSLAYSPGVAFACEAIVEDATQASELTARGNLVAVITNGTAVLGL
GNIGPLASKPVMEGKGVLFQKFAGIDVFDIEINENDPDKLVDIIASLEPTFGGINLEDIKAPECFIVERKLRERMNIPVF
HDDQHGTAIIVGAAVLNALVVTGKKIEEVKLATTGMGAAGISCVNMLVSLGLKPENILALDRDGVIHTGRTDLDPDKQRY
ARDTDKRTLAEIVEGADIFLGLSAAGILKPEMVASMARQPVIFALANPNPEITPEVAKAVRPDCIIGTGRSDYPNQINNV
LCFPYLFRGALDVGATGINEEMKIACVKAIAAMARREASDLGAAYGGETPSFGPDYLIPRPLDPRLLVELSSAVAQAAMD
SGVATRPITDMEAYRDKLGQFVYRTSLMMKPVYDRARADKQRVVYAEGEEEVVLRAVQNVVDEGLAFPILIGRPDVIEAR
IERMGLRLTAGVDFEITNILDDPRFNDYWQYYHALTERRGVTVTAAKELMRSRPTLIAAVMVARGEADAMLSGVVGRFHK
KLGYARSVIPLEPRVSSTSAMTGVINQLGVFFFLDTHVQEDPTVEQVVEATLQAAYRLKLFGIEPNIALLSHSNFGSHDS
RDALKMRQVREALLKRKPELNIDGEMQGDTAWDEALRKQIMPNSTLKGRANLFVLPNLEAANIAYNLVRVFTDGVAIGPI
LMGISKPVHILTTSATSRRVMNMTAIAAVDAQIRRQRDAEKAAADKGSD

Sequences:

>Translated_769_residues
MSTDDFKQAALDYHRQQPAGKIKVTATKPMLTQRDLSLAYSPGVAFACEAIVEDATQASELTARGNLVAVITNGTAVLGL
GNIGPLASKPVMEGKGVLFQKFAGIDVFDIEINENDPDKLVDIIASLEPTFGGINLEDIKAPECFIVERKLRERMNIPVF
HDDQHGTAIIVGAAVLNALVVTGKKIEEVKLATTGMGAAGISCVNMLVSLGLKPENILALDRDGVIHTGRTDLDPDKQRY
ARDTDKRTLAEIVEGADIFLGLSAAGILKPEMVASMARQPVIFALANPNPEITPEVAKAVRPDCIIGTGRSDYPNQINNV
LCFPYLFRGALDVGATGINEEMKIACVKAIAAMARREASDLGAAYGGETPSFGPDYLIPRPLDPRLLVELSSAVAQAAMD
SGVATRPITDMEAYRDKLGQFVYRTSLMMKPVYDRARADKQRVVYAEGEEEVVLRAVQNVVDEGLAFPILIGRPDVIEAR
IERMGLRLTAGVDFEITNILDDPRFNDYWQYYHALTERRGVTVTAAKELMRSRPTLIAAVMVARGEADAMLSGVVGRFHK
KLGYARSVIPLEPRVSSTSAMTGVINQLGVFFFLDTHVQEDPTVEQVVEATLQAAYRLKLFGIEPNIALLSHSNFGSHDS
RDALKMRQVREALLKRKPELNIDGEMQGDTAWDEALRKQIMPNSTLKGRANLFVLPNLEAANIAYNLVRVFTDGVAIGPI
LMGISKPVHILTTSATSRRVMNMTAIAAVDAQIRRQRDAEKAAADKGSD
>Mature_768_residues
STDDFKQAALDYHRQQPAGKIKVTATKPMLTQRDLSLAYSPGVAFACEAIVEDATQASELTARGNLVAVITNGTAVLGLG
NIGPLASKPVMEGKGVLFQKFAGIDVFDIEINENDPDKLVDIIASLEPTFGGINLEDIKAPECFIVERKLRERMNIPVFH
DDQHGTAIIVGAAVLNALVVTGKKIEEVKLATTGMGAAGISCVNMLVSLGLKPENILALDRDGVIHTGRTDLDPDKQRYA
RDTDKRTLAEIVEGADIFLGLSAAGILKPEMVASMARQPVIFALANPNPEITPEVAKAVRPDCIIGTGRSDYPNQINNVL
CFPYLFRGALDVGATGINEEMKIACVKAIAAMARREASDLGAAYGGETPSFGPDYLIPRPLDPRLLVELSSAVAQAAMDS
GVATRPITDMEAYRDKLGQFVYRTSLMMKPVYDRARADKQRVVYAEGEEEVVLRAVQNVVDEGLAFPILIGRPDVIEARI
ERMGLRLTAGVDFEITNILDDPRFNDYWQYYHALTERRGVTVTAAKELMRSRPTLIAAVMVARGEADAMLSGVVGRFHKK
LGYARSVIPLEPRVSSTSAMTGVINQLGVFFFLDTHVQEDPTVEQVVEATLQAAYRLKLFGIEPNIALLSHSNFGSHDSR
DALKMRQVREALLKRKPELNIDGEMQGDTAWDEALRKQIMPNSTLKGRANLFVLPNLEAANIAYNLVRVFTDGVAIGPIL
MGISKPVHILTTSATSRRVMNMTAIAAVDAQIRRQRDAEKAAADKGSD

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=411, Percent_Identity=24.330900243309, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI62420880, Length=411, Percent_Identity=24.330900243309, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI239049447, Length=411, Percent_Identity=24.330900243309, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI4505143, Length=409, Percent_Identity=24.2053789731051, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788806, Length=755, Percent_Identity=58.8079470198675, Blast_Score=901, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=318, Percent_Identity=29.559748427673, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788800, Length=323, Percent_Identity=29.1021671826625, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI87081919, Length=401, Percent_Identity=22.1945137157107, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17537199, Length=343, Percent_Identity=27.6967930029155, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281362674, Length=490, Percent_Identity=26.734693877551, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356279, Length=490, Percent_Identity=26.734693877551, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362672, Length=490, Percent_Identity=27.1428571428571, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78707242, Length=406, Percent_Identity=24.8768472906404, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707238, Length=406, Percent_Identity=24.8768472906404, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707240, Length=406, Percent_Identity=24.8768472906404, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83678; Mature: 83547

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDDFKQAALDYHRQQPAGKIKVTATKPMLTQRDLSLAYSPGVAFACEAIVEDATQASE
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHH
LTARGNLVAVITNGTAVLGLGNIGPLASKPVMEGKGVLFQKFAGIDVFDIEINENDPDKL
HEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCHHHH
VDIIASLEPTFGGINLEDIKAPECFIVERKLRERMNIPVFHDDQHGTAIIVGAAVLNALV
HHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
VTGKKIEEVKLATTGMGAAGISCVNMLVSLGLKPENILALDRDGVIHTGRTDLDPDKQRY
HCCCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCHHHH
ARDTDKRTLAEIVEGADIFLGLSAAGILKPEMVASMARQPVIFALANPNPEITPEVAKAV
HCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHC
RPDCIIGTGRSDYPNQINNVLCFPYLFRGALDVGATGINEEMKIACVKAIAAMARREASD
CCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGAAYGGETPSFGPDYLIPRPLDPRLLVELSSAVAQAAMDSGVATRPITDMEAYRDKLGQ
HCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FVYRTSLMMKPVYDRARADKQRVVYAEGEEEVVLRAVQNVVDEGLAFPILIGRPDVIEAR
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
IERMGLRLTAGVDFEITNILDDPRFNDYWQYYHALTERRGVTVTAAKELMRSRPTLIAAV
HHHCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHH
MVARGEADAMLSGVVGRFHKKLGYARSVIPLEPRVSSTSAMTGVINQLGVFFFLDTHVQE
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCC
DPTVEQVVEATLQAAYRLKLFGIEPNIALLSHSNFGSHDSRDALKMRQVREALLKRKPEL
CCCHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
NIDGEMQGDTAWDEALRKQIMPNSTLKGRANLFVLPNLEAANIAYNLVRVFTDGVAIGPI
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHH
LMGISKPVHILTTSATSRRVMNMTAIAAVDAQIRRQRDAEKAAADKGSD
HHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STDDFKQAALDYHRQQPAGKIKVTATKPMLTQRDLSLAYSPGVAFACEAIVEDATQASE
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHH
LTARGNLVAVITNGTAVLGLGNIGPLASKPVMEGKGVLFQKFAGIDVFDIEINENDPDKL
HEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCHHHH
VDIIASLEPTFGGINLEDIKAPECFIVERKLRERMNIPVFHDDQHGTAIIVGAAVLNALV
HHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
VTGKKIEEVKLATTGMGAAGISCVNMLVSLGLKPENILALDRDGVIHTGRTDLDPDKQRY
HCCCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCHHHH
ARDTDKRTLAEIVEGADIFLGLSAAGILKPEMVASMARQPVIFALANPNPEITPEVAKAV
HCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHC
RPDCIIGTGRSDYPNQINNVLCFPYLFRGALDVGATGINEEMKIACVKAIAAMARREASD
CCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGAAYGGETPSFGPDYLIPRPLDPRLLVELSSAVAQAAMDSGVATRPITDMEAYRDKLGQ
HCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FVYRTSLMMKPVYDRARADKQRVVYAEGEEEVVLRAVQNVVDEGLAFPILIGRPDVIEAR
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
IERMGLRLTAGVDFEITNILDDPRFNDYWQYYHALTERRGVTVTAAKELMRSRPTLIAAV
HHHCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHH
MVARGEADAMLSGVVGRFHKKLGYARSVIPLEPRVSSTSAMTGVINQLGVFFFLDTHVQE
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCC
DPTVEQVVEATLQAAYRLKLFGIEPNIALLSHSNFGSHDSRDALKMRQVREALLKRKPEL
CCCHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
NIDGEMQGDTAWDEALRKQIMPNSTLKGRANLFVLPNLEAANIAYNLVRVFTDGVAIGPI
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHH
LMGISKPVHILTTSATSRRVMNMTAIAAVDAQIRRQRDAEKAAADKGSD
HHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]