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The map label for this gene is ywrD [H]

Identifier: 78049134

GI number: 78049134

Start: 4106126

End: 4107835

Strand: Reverse

Name: ywrD [H]

Synonym: XCV3578

Alternate gene names: 78049134

Gene position: 4107835-4106126 (Counterclockwise)

Preceding gene: 78049140

Following gene: 78049133

Centisome position: 79.33

GC content: 66.08

Gene sequence:

>1710_bases
ATGCGTCGCGTACCTGTGTTGTTGGTGTCTGCTCTGGCGTTGCTCGCGCCGCCCCTCGGCGCTGCCGACCGCGTCACCGG
GCAGCCGTTTGCCACCCGCTCGGAAGTCATTGCGCCGCATGCCATGGCCGCGACCTCGCAACCGCTGGCCACCCAGATCG
CGCTGGACGTGATGAAGGATGGCGGCTCGGCGGTGGATGCAGCGATCGCGGCTAATGCGGCGCTGGGCCTGATGGAGCCC
ACCGGCAATGGCGTGGGAGGGGATCTATTTGCGATCGTTTGGGACCCCAAGACCCACAAGCTCTACGGCTACAACGGCTC
CGGCCGCTCGCCCAAATCGCTGACCCTGGCCGAATTCCAGCGCCGTGGCTTGAAGGACATTCCGCCGACCGGCCCGTTGC
CGGTGTCGGTGCCGGGCGCGGTGGACGGCTGGTTCGCGCTGCACGCGCGCTTCGGGCGCAAGCCGATGGCACAGAACCTG
GCGCCGGCGATCCGCTACGCGCGCGAAGGCCATCCGGTCGCCGAGACCATCGCCTATTACTGGGACCGTTCGGTGCCGCG
CCTGTCGCAATACCCCGGGTTCAAGGAGCAATTCACCATCGACGGCCACGCCCCGCGCAAGGGCGAGCTGTGGAAGAACC
CGAACCTGGCCAACACGCTGCAGCAGATCGCCGACGGCGGCCGCGACGCGTTCTACGAGGGCGAGATCGCGCGCACCATC
GGTGCCTACTTCAAGGCCAACGGCGGCTACCTCAGCTATGAGGACCTGGCCAGCCATACGGGCGAGTGGGTCGAACCGGT
GTCCACCAATTATCGCGGCGTTGATGTGTGGGAACTGCCGCCCAACAGCCAGGGCATCGCCGCGTTGCAGATGCTCAATA
TCCTGGAGGGTTACGATTTCTCCAAGATTCCGTTCGGCTCGGCCGAGCACGTGCACTTGTTCACCGAGGCCAAGAAGCTG
GCCTTCGCCGACCGCGCGCGCTTCTACGCCGACCCGGCGTTTCAGCCGGCACCGCTGGCCAGGCTGATCTCCAAGGACTA
CGCCAACCAGCGGCGCGCGCTGATTTCGATGGACAAGGCGCTCAAGGAAGTACAGCCAGGGACACCCAGGCAACTGGAAG
AAGGCGACACCATCTATATGACCGTGGCCGATGCCGACGGCATGATGGTCTCGCTGATCCAGTCCAACTACCGCGGCATG
GGCAGCGGCATGGCGCCGCCGGGGCTGGGTTTCATCCTGCAGGACCGCGGCGAGATGTTCGTGCTGAAGAAGGATCATCC
CAACGGCTACGCGCCGGGCAAGCGGCCGTTCCAGACCATCATCCCGGCCTTCGTCACCAAGGACGGCAAGCCCTGGCTGA
GCTTCGGCGTGATGGGCGGGGCGATGCAGCCGCAGGGGCACGTGCAGATCGTGATGAACCTGGTGGACTTCCACATGAAC
CTGCAGGAAGCCGGCGACGCGCCGCGTATCCAGCACGAGGACTCCACCGAACCGACCGGGCAGGCCACCGCGATGCGCGA
TGGCGGCGAGGTGAATCTGGAAACCGGCTTCTCCTACGACACCATCCGCGCGCTGATGCGCAAAGGCCACCGGGTGATCT
TTGCCGACGGTCCGTACGGCGGGTATCAGGCCATCGCCCGCGATGCGGCCAGCGGCGTGTACTACGGTGCGTCGGAAAGC
CGCAAGGACGGCCAGGCGGCCGGATACTGA

Upstream 100 bases:

>100_bases
CTGCGCGGCATTGAGCGCGCTGCCAAGTGTCGATCGGACGGCAGGACGCGGCCCGCTGGTATGGTTGGCACCTCATTCTC
AGTGTCAGGGGCCCTCGGTG

Downstream 100 bases:

>100_bases
GCGCGCGACACGGTTGAGGTTGCCGCTCAACTCCGGCCGCCGCACGCCGCTAATCACGGGATGGAGCAGGAGCCCCTCAT
GAATTCGATGCAACAGCCCG

Product: gamma-glutamyltranspeptidase precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKDGGSAVDAAIAANAALGLMEP
TGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQRRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNL
APAIRYAREGHPVAETIAYYWDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYEGEIARTI
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDFSKIPFGSAEHVHLFTEAKKL
AFADRARFYADPAFQPAPLARLISKDYANQRRALISMDKALKEVQPGTPRQLEEGDTIYMTVADADGMMVSLIQSNYRGM
GSGMAPPGLGFILQDRGEMFVLKKDHPNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
LQEAGDAPRIQHEDSTEPTGQATAMRDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYGGYQAIARDAASGVYYGASES
RKDGQAAGY

Sequences:

>Translated_569_residues
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKDGGSAVDAAIAANAALGLMEP
TGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQRRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNL
APAIRYAREGHPVAETIAYYWDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYEGEIARTI
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDFSKIPFGSAEHVHLFTEAKKL
AFADRARFYADPAFQPAPLARLISKDYANQRRALISMDKALKEVQPGTPRQLEEGDTIYMTVADADGMMVSLIQSNYRGM
GSGMAPPGLGFILQDRGEMFVLKKDHPNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
LQEAGDAPRIQHEDSTEPTGQATAMRDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYGGYQAIARDAASGVYYGASES
RKDGQAAGY
>Mature_569_residues
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKDGGSAVDAAIAANAALGLMEP
TGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQRRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNL
APAIRYAREGHPVAETIAYYWDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYEGEIARTI
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDFSKIPFGSAEHVHLFTEAKKL
AFADRARFYADPAFQPAPLARLISKDYANQRRALISMDKALKEVQPGTPRQLEEGDTIYMTVADADGMMVSLIQSNYRGM
GSGMAPPGLGFILQDRGEMFVLKKDHPNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
LQEAGDAPRIQHEDSTEPTGQATAMRDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYGGYQAIARDAASGVYYGASES
RKDGQAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=543, Percent_Identity=30.2025782688766, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI73915090, Length=543, Percent_Identity=30.2025782688766, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI73915096, Length=543, Percent_Identity=30.2025782688766, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI73915094, Length=543, Percent_Identity=30.2025782688766, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI113429326, Length=554, Percent_Identity=28.3393501805054, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI113429324, Length=549, Percent_Identity=28.4153005464481, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI109148539, Length=502, Percent_Identity=27.0916334661355, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI153266901, Length=561, Percent_Identity=25.1336898395722, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI153266885, Length=560, Percent_Identity=25.1785714285714, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI153266907, Length=560, Percent_Identity=24.1071428571429, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1789856, Length=555, Percent_Identity=32.7927927927928, Blast_Score=257, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI193208245, Length=499, Percent_Identity=23.0460921843687, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=560, Percent_Identity=23.9285714285714, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=499, Percent_Identity=23.0460921843687, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=474, Percent_Identity=24.2616033755274, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI212646519, Length=474, Percent_Identity=24.2616033755274, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=485, Percent_Identity=26.1855670103093, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24642670, Length=550, Percent_Identity=26.7272727272727, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24642666, Length=550, Percent_Identity=26.7272727272727, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI45551474, Length=550, Percent_Identity=26.7272727272727, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI161077880, Length=550, Percent_Identity=26.7272727272727, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI161077878, Length=550, Percent_Identity=26.7272727272727, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI18859893, Length=462, Percent_Identity=27.0562770562771, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161077496, Length=508, Percent_Identity=25.1968503937008, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859741, Length=482, Percent_Identity=25.7261410788382, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61646; Mature: 61646

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHC
GGSAVDAAIAANAALGLMEPTGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQ
CCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHH
RRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNLAPAIRYAREGHPVAETIAYY
HCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
WDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYEGEIARTI
HCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHHH
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDF
HHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
SKIPFGSAEHVHLFTEAKKLAFADRARFYADPAFQPAPLARLISKDYANQRRALISMDKA
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LKEVQPGTPRQLEEGDTIYMTVADADGMMVSLIQSNYRGMGSGMAPPGLGFILQDRGEMF
HHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEE
VLKKDHPNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
EEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
LQEAGDAPRIQHEDSTEPTGQATAMRDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYG
HHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCC
GYQAIARDAASGVYYGASESRKDGQAAGY
HHHHHHHHHHCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRRVPVLLVSALALLAPPLGAADRVTGQPFATRSEVIAPHAMAATSQPLATQIALDVMKD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHC
GGSAVDAAIAANAALGLMEPTGNGVGGDLFAIVWDPKTHKLYGYNGSGRSPKSLTLAEFQ
CCCHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHH
RRGLKDIPPTGPLPVSVPGAVDGWFALHARFGRKPMAQNLAPAIRYAREGHPVAETIAYY
HCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
WDRSVPRLSQYPGFKEQFTIDGHAPRKGELWKNPNLANTLQQIADGGRDAFYEGEIARTI
HCCCCCHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHHH
GAYFKANGGYLSYEDLASHTGEWVEPVSTNYRGVDVWELPPNSQGIAALQMLNILEGYDF
HHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
SKIPFGSAEHVHLFTEAKKLAFADRARFYADPAFQPAPLARLISKDYANQRRALISMDKA
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LKEVQPGTPRQLEEGDTIYMTVADADGMMVSLIQSNYRGMGSGMAPPGLGFILQDRGEMF
HHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCEE
VLKKDHPNGYAPGKRPFQTIIPAFVTKDGKPWLSFGVMGGAMQPQGHVQIVMNLVDFHMN
EEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
LQEAGDAPRIQHEDSTEPTGQATAMRDGGEVNLETGFSYDTIRALMRKGHRVIFADGPYG
HHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCC
GYQAIARDAASGVYYGASESRKDGQAAGY
HHHHHHHHHHCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]