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The map label for this gene is gdh [H]

Identifier: 78049102

GI number: 78049102

Start: 4062448

End: 4063263

Strand: Reverse

Name: gdh [H]

Synonym: XCV3546

Alternate gene names: 78049102

Gene position: 4063263-4062448 (Counterclockwise)

Preceding gene: 78049103

Following gene: 78049100

Centisome position: 78.46

GC content: 65.93

Gene sequence:

>816_bases
ATGACGTTATCGGGCAAAACCCTGTTCATCACCGGTGCATCGCGTGGGATTGGCTTGGCGATTGCGTTGCGGGCGGCGCG
CGATGGGGCGAATGTGGCGATTGCGGCCAAGTCGGCGGTGGCCAATCCCAAATTGCCTGGCACCATCCATAGCGCGGCCA
CGGCGGTGACGGCGGCCGGTGGGCAGGCACTGGCGCTCAAGTGCGACATCCGCGACGAAGATCAGGTGCGTGCGGCAGTG
GCGGCAACGGTCGATGCGTTCGGCGGGATCGACATCCTGGTCAACAACGCCAGTGCGATCTGGTTGCGCGGTACGTTGGA
CACGCCGATGAAGCGCTTCGATCTGATGCAGCAGGTCAACGCGCGCGGCAGTTTCCTGTGCGCGCAGGCATGCCTGCCGC
ATCTGCTGCAGGCGGCCAATCCGCACATCCTCACCTTGGCCCCGCCGCCGTCGTTGAACCCGGCGTGGTGGGGCGCGCAC
ACCGGCTACACGCTGGCCAAGATGGGCATGAGTCTGGTCACCCTGGGGCTGGCCGCGGAATTCGGCCCGCAAGGCGTGGC
GATCAATGCGTTGTGGCCGCGTACCGTGATCGCCACTGATGCCATCAACATGCTTGCCGGCGTGGACGCGGCGGCCTGCC
GTCGGCCGGAGATCATGGCCGACGCCGCGCATGCGGTGCTGACGCGCGCCGCAGCCGGGTTTTACGGCCGGTTCCTGATC
GATGACGAGGTGCTCGCCCAGGCTGGCATCACCGACTTGAGCGGCTATGCAATGGATCCATCGCGCGCGCTGTTGCCAGA
TCTGTTTCTGGACTGA

Upstream 100 bases:

>100_bases
TTGGGGATTCGCAAGAGCGTATTGCTTGAGCGGTGGGTGGTTGGTGGTAGCAATGAAGGAATAAGCTCTTACGAATCTCC
AATCCCGACTCCCTAATCCC

Downstream 100 bases:

>100_bases
GAGCGGCTAACCACAGGGTACGCACTTGTCGTGAGCGTGGACGGCACGGCGCAACCGCCGTGTACGCGTGGCACACGCCC
TGCCGAGCAACGGCCGCGTC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTLSGKTLFITGASRGIGLAIALRAARDGANVAIAAKSAVANPKLPGTIHSAATAVTAAGGQALALKCDIRDEDQVRAAV
AATVDAFGGIDILVNNASAIWLRGTLDTPMKRFDLMQQVNARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAH
TGYTLAKMGMSLVTLGLAAEFGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGRFLI
DDEVLAQAGITDLSGYAMDPSRALLPDLFLD

Sequences:

>Translated_271_residues
MTLSGKTLFITGASRGIGLAIALRAARDGANVAIAAKSAVANPKLPGTIHSAATAVTAAGGQALALKCDIRDEDQVRAAV
AATVDAFGGIDILVNNASAIWLRGTLDTPMKRFDLMQQVNARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAH
TGYTLAKMGMSLVTLGLAAEFGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGRFLI
DDEVLAQAGITDLSGYAMDPSRALLPDLFLD
>Mature_270_residues
TLSGKTLFITGASRGIGLAIALRAARDGANVAIAAKSAVANPKLPGTIHSAATAVTAAGGQALALKCDIRDEDQVRAAVA
ATVDAFGGIDILVNNASAIWLRGTLDTPMKRFDLMQQVNARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAHT
GYTLAKMGMSLVTLGLAAEFGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGRFLID
DEVLAQAGITDLSGYAMDPSRALLPDLFLD

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254986, Length=270, Percent_Identity=52.5925925925926, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI10190704, Length=237, Percent_Identity=28.2700421940928, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI209862901, Length=207, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI19923983, Length=207, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI19923817, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=199, Percent_Identity=27.1356783919598, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI87082100, Length=191, Percent_Identity=32.9842931937173, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367175, Length=191, Percent_Identity=28.2722513089005, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789208, Length=195, Percent_Identity=29.7435897435897, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790717, Length=197, Percent_Identity=24.8730964467005, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=267, Percent_Identity=52.059925093633, Blast_Score=292, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17558628, Length=269, Percent_Identity=53.1598513011152, Blast_Score=291, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71994604, Length=186, Percent_Identity=31.1827956989247, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=233, Percent_Identity=27.4678111587983, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=225, Percent_Identity=28, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=204, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=148, Percent_Identity=31.0810810810811, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=201, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=276, Percent_Identity=25.7246376811594, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=205, Percent_Identity=28.780487804878, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=239, Percent_Identity=28.0334728033473, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=26.9035532994924, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=28.5, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21357673, Length=272, Percent_Identity=56.9852941176471, Blast_Score=320, Evalue=9e-88,
Organism=Drosophila melanogaster, GI23397609, Length=198, Percent_Identity=35.8585858585859, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355319, Length=193, Percent_Identity=29.0155440414508, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=267, Percent_Identity=26.9662921348315, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571526, Length=209, Percent_Identity=31.5789473684211, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859837, Length=221, Percent_Identity=29.8642533936652, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24644339, Length=269, Percent_Identity=26.3940520446097, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 28049; Mature: 27918

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSGKTLFITGASRGIGLAIALRAARDGANVAIAAKSAVANPKLPGTIHSAATAVTAAG
CCCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHEECC
GQALALKCDIRDEDQVRAAVAATVDAFGGIDILVNNASAIWLRGTLDTPMKRFDLMQQVN
CCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHC
ARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAHTGYTLAKMGMSLVTLGLAAE
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGRFLI
CCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEE
DDEVLAQAGITDLSGYAMDPSRALLPDLFLD
CHHHHHHCCCCCCCCCCCCCCHHHCCHHHCC
>Mature Secondary Structure 
TLSGKTLFITGASRGIGLAIALRAARDGANVAIAAKSAVANPKLPGTIHSAATAVTAAG
CCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHEECC
GQALALKCDIRDEDQVRAAVAATVDAFGGIDILVNNASAIWLRGTLDTPMKRFDLMQQVN
CCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCCHHHHHHHHHHHC
ARGSFLCAQACLPHLLQAANPHILTLAPPPSLNPAWWGAHTGYTLAKMGMSLVTLGLAAE
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGPQGVAINALWPRTVIATDAINMLAGVDAAACRRPEIMADAAHAVLTRAAAGFYGRFLI
CCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEE
DDEVLAQAGITDLSGYAMDPSRALLPDLFLD
CHHHHHHCCCCCCCCCCCCCCHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3082854; 8969502; 9384377 [H]