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The map label for this gene is pepP [H]

Identifier: 78049078

GI number: 78049078

Start: 4035139

End: 4036467

Strand: Reverse

Name: pepP [H]

Synonym: XCV3522

Alternate gene names: 78049078

Gene position: 4036467-4035139 (Counterclockwise)

Preceding gene: 78049079

Following gene: 78049069

Centisome position: 77.95

GC content: 65.69

Gene sequence:

>1329_bases
ATGAAGAAGCTCACCGGGATTGGCGCGGCCGAGTACGCGCGCCGGCGCAAGCAGCTGATGCAGATGGCGGGCGAGCAGGC
GATTTTGATCTTGCCGGCCGCGCCTGAGCGCGTGCGCAGCCACGACACGCATTACCCATATCGACAGGACTCGGATTTCT
GGTATCTGAGCGGGTTTCCGGAGCCCGAAGCGGTGCTGGTGCTGGTGCCCGGCCGCAAGCATGGCGAAGCGATTCTGTTC
TGCCGCGAACGCGATGCCGAGCGCGAAGCCTGGGATGGCCCGCGCGAGGGCCAGGAAGGTGCGGTGGAACGCTACGGCAT
GGACGATGCGTACCCCATCGACGATGTCGACGAGATCCTGCCCGGCCTGCTGGAAGGGCGCAGCCGCGTGTACTACCACT
TCGGGCGCGATGTCGATTTCGATCTCAAATTGATCGGCTGGCTCAAGCGCGTGCGCGAGCAGGTGCGCCACGGCGCGCAG
CCGCCACACGAATTCCTCGAGCTCGGGCATCTGTTGCACGAGCAGCGCCTGTTCAAATCACGCGACGAAATCGCGCTGAT
GCAGCAGGCTGCCGACATCAGCGTGCGCGCGCACCGTGCAGCGATGCGGATGGCGCGGCCGGGTGTGCACGAATACGAAC
TGCAGGCCGAGGTCGAGCGCGAATTCCGCGCTGCCGACGCATGGCCGGCATACGGCAGCATCGTCGGCACCGGCAGCAAC
GCCTGCGTGCTGCACTACCGTGCCAACAATGCGCGCAGCCGCGATGGCGAGCTGGTGCTGATCGACGCCGGTGCCGAATA
TCGTGGCTATGCGGCCGATATCACCCGCACCTTTCCGGTCAACGGCCGCTTCACGCCAGCGCAGCGTGCATTGCACGATC
TGGTCGGTGCTGCGCAGGCGGCTGCGCTTGCACAGGCGCGCCCCGGCGTGGCGTACGAAGCCGGGCATCTGGCGGCGGTG
GAAACCTTGACCGAAGGCCTGCTGCGCCTGGGCCTGCTCAAGGGAAAACTTGAGCGCAACATCGCCGATGGACACTACAA
ACGCTTTTATCGGCACAAGACCGGCCATTGGCTGGGCCTGGATGTGCACGATGTGGGCGACTACCGGCTGGCCGGCGATT
CGCGGCTGCTCGAGCCCGGCATGGTGTTCACCATCGAACCGGGGCTCTACGTGTCGGCCGACGACACTTCGGTAGAGGCC
AAGTGGCGCGGCATCGGCATTCGCACCGAAGACAATGTGCTGATCACTGCCGATGGCCACCGTGTGCTGACCGATGCGCT
GGCGCGCAGTGCCGACGAGATCGAAGCGGAGATGGCCGGCGGCGCATGA

Upstream 100 bases:

>100_bases
TGGCCGAGATCGAAGAATTCGTACGCGTGGCGGTGCTGTTGCTGCATGGCGACTGCGTGATGGGGCCGCGCTTTCGCCAG
CGTCTGAACTGATTGCCGGC

Downstream 100 bases:

>100_bases
GCGCCGGCGTGCACGACATTCATAAGGACCGACACGCTGCAGCCGGCGTCATGGTGCAGGCGTTGCCGCAGCGCAATTGC
CGCAGCAGTGCCATGGCGGA

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAAPERVRSHDTHYPYRQDSDFWYLSGFPEPEAVLVLVPGRKHGEAILF
CRERDAEREAWDGPREGQEGAVERYGMDDAYPIDDVDEILPGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQ
PPHEFLELGHLLHEQRLFKSRDEIALMQQAADISVRAHRAAMRMARPGVHEYELQAEVEREFRAADAWPAYGSIVGTGSN
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQAAALAQARPGVAYEAGHLAAV
ETLTEGLLRLGLLKGKLERNIADGHYKRFYRHKTGHWLGLDVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEA
KWRGIGIRTEDNVLITADGHRVLTDALARSADEIEAEMAGGA

Sequences:

>Translated_442_residues
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAAPERVRSHDTHYPYRQDSDFWYLSGFPEPEAVLVLVPGRKHGEAILF
CRERDAEREAWDGPREGQEGAVERYGMDDAYPIDDVDEILPGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQ
PPHEFLELGHLLHEQRLFKSRDEIALMQQAADISVRAHRAAMRMARPGVHEYELQAEVEREFRAADAWPAYGSIVGTGSN
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQAAALAQARPGVAYEAGHLAAV
ETLTEGLLRLGLLKGKLERNIADGHYKRFYRHKTGHWLGLDVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEA
KWRGIGIRTEDNVLITADGHRVLTDALARSADEIEAEMAGGA
>Mature_442_residues
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAAPERVRSHDTHYPYRQDSDFWYLSGFPEPEAVLVLVPGRKHGEAILF
CRERDAEREAWDGPREGQEGAVERYGMDDAYPIDDVDEILPGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQ
PPHEFLELGHLLHEQRLFKSRDEIALMQQAADISVRAHRAAMRMARPGVHEYELQAEVEREFRAADAWPAYGSIVGTGSN
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQAAALAQARPGVAYEAGHLAAV
ETLTEGLLRLGLLKGKLERNIADGHYKRFYRHKTGHWLGLDVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEA
KWRGIGIRTEDNVLITADGHRVLTDALARSADEIEAEMAGGA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=451, Percent_Identity=36.5853658536585, Blast_Score=265, Evalue=9e-71,
Organism=Homo sapiens, GI149589008, Length=466, Percent_Identity=31.7596566523605, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI260593665, Length=301, Percent_Identity=34.21926910299, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI260593663, Length=460, Percent_Identity=28.0434782608696, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1789275, Length=441, Percent_Identity=45.3514739229025, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790282, Length=285, Percent_Identity=31.9298245614035, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=31.8897637795276, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=466, Percent_Identity=32.1888412017167, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=370, Percent_Identity=27.5675675675676, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=452, Percent_Identity=30.3097345132743, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321118, Length=435, Percent_Identity=28.9655172413793, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19920384, Length=449, Percent_Identity=34.7438752783964, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI21357079, Length=465, Percent_Identity=31.3978494623656, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49364; Mature: 49364

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAAPERVRSHDTHYPYRQDSDFWYLSGFP
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCCCCCCCCEEEECCCC
EPEAVLVLVPGRKHGEAILFCRERDAEREAWDGPREGQEGAVERYGMDDAYPIDDVDEIL
CCCEEEEEECCCCCCCEEEEEECCCCCHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
PGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQPPHEFLELGHLLHEQRLFKS
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
RDEIALMQQAADISVRAHRAAMRMARPGVHEYELQAEVEREFRAADAWPAYGSIVGTGSN
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQA
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
AALAQARPGVAYEAGHLAAVETLTEGLLRLGLLKGKLERNIADGHYKRFYRHKTGHWLGL
HHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEE
DVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEAKWRGIGIRTEDNVLITADGH
EEECCCCEEECCCCCCCCCCEEEEECCCEEEECCCCCEEEEEEEEEEEECCCEEEEECCC
RVLTDALARSADEIEAEMAGGA
HHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MKKLTGIGAAEYARRRKQLMQMAGEQAILILPAAPERVRSHDTHYPYRQDSDFWYLSGFP
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCCCCCCCCCCCEEEECCCC
EPEAVLVLVPGRKHGEAILFCRERDAEREAWDGPREGQEGAVERYGMDDAYPIDDVDEIL
CCCEEEEEECCCCCCCEEEEEECCCCCHHHCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
PGLLEGRSRVYYHFGRDVDFDLKLIGWLKRVREQVRHGAQPPHEFLELGHLLHEQRLFKS
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
RDEIALMQQAADISVRAHRAAMRMARPGVHEYELQAEVEREFRAADAWPAYGSIVGTGSN
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCC
ACVLHYRANNARSRDGELVLIDAGAEYRGYAADITRTFPVNGRFTPAQRALHDLVGAAQA
EEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHHH
AALAQARPGVAYEAGHLAAVETLTEGLLRLGLLKGKLERNIADGHYKRFYRHKTGHWLGL
HHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEE
DVHDVGDYRLAGDSRLLEPGMVFTIEPGLYVSADDTSVEAKWRGIGIRTEDNVLITADGH
EEECCCCEEECCCCCCCCCCEEEEECCCEEEECCCCCEEEEEEEEEEEECCCEEEEECCC
RVLTDALARSADEIEAEMAGGA
HHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]