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The map label for this gene is gcvT [H]

Identifier: 78048752

GI number: 78048752

Start: 3634194

End: 3635303

Strand: Reverse

Name: gcvT [H]

Synonym: XCV3196

Alternate gene names: 78048752

Gene position: 3635303-3634194 (Counterclockwise)

Preceding gene: 78048753

Following gene: 78048751

Centisome position: 70.2

GC content: 65.32

Gene sequence:

>1110_bases
ATGACCCAGAAGACCATCCTCAACGACACCCATCGTGCGCTTGGCGCCAAGATGGTCGACTTCGGCGGCTGGGACATGCC
GATCCACTACGGCTCGCAACTGGACGAGCACCACCAGGTGCGCCGCGACGCCGGCATGTTCGACGTCAGCCACATGACGG
TGGTCGACCTGCACGGTGCGCGCGTGCGCGAGTTTCTGCGCTACCTGCTCGCCAACTCGGTGGACAAGCTCAAGGTCTCC
GGCAAGGCGCTGTACACCTGCATGCTCAATCCCCAGGGCGGTGTGATCGACGACCTCATCGTCTACTACATGACGGAAGA
TTTCTTCCGTCTGGTGGTCAACGCCGCCACCCGCGAAAAGGACCTGCAGTGGATCGGCGAGCAGGCCGCACGCTTCGACG
TGCGGGTGGAAGAGCGCAGCGACTTCGCCATGATTGCCGTGCAAGGTCCCGGCGCGCGCACCAAGGTCATCGACCTGCTC
GACCCGGCCGACACCGCAGCGGCGAGCAAGCTCGGCCGTTTCGCCGCGCTGCAGACGCGTTCGCGCGATGGCATTGATTT
GTTCCTTGCGCGCACCGGCTACACCGGCGAAGACGGTTTCGAGATCGTGTTGCCGCAAGAGGCTGCCGTCGCATTCTGGA
ATGCGTTGCTCGCGCAGGGCGTCAAACCCGCAGGCCTGGGTGCACGCGACACCCTGCGTCTGGAAGCGGGCATGAATCTC
TATGGGCAGGACATGGACGATGGCGTTACCCCTTACGAGGCCGGGCTGGCCTGGACGATCGCCCTGGACGAAGGACGCGA
CTTCATCGGTCGCAGCGTGCTCGAATATCAAAAGGCGCAGGGCGCACCGCGTCAGCTGATCGGTGTGGTGATGGACGAGA
AGGGCGTGTTGCGGCATGGCCAGACCGTGCTCACCGCCAGTGGCGAAGGCGAGATCCTGTCCGGCACGTTCTCGCCCACG
CTGGGCAAGGCGATCGCCTTCGCGCGCGTGCCGGCCGGCAGCATCGAGCAGCTGCGGGTGGACATCCGCGGCAAGCAGGT
GCCGCTGCGCGCAGTGAAGTTTCCGTTCGTGCGCGATGGCCAGGCACAGCCCGGCGTGCTCGGCGACTGA

Upstream 100 bases:

>100_bases
GCGTTCGCGCCCGCAGGCGGCGCAACCACACAGCGGTATGCCGTTCCCCCAAGCGTGACAGGACGGCGATAATGGCCGTC
TTTCCTTTGGAACGGCGCAC

Downstream 100 bases:

>100_bases
CTCGTGTAGCGCCGCGTACTGCGCGCGGCACTGCGCCCGGGTCCGTATCCGTATCGCCATCGCCCCACCGCCGTGCGTGC
ACCTGTCTTGTCGCGCGGTC

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVREFLRYLLANSVDKLKVS
GKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREKDLQWIGEQAARFDVRVEERSDFAMIAVQGPGARTKVIDLL
DPADTAAASKLGRFAALQTRSRDGIDLFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLEYQKAQGAPRQLIGVVMDEKGVLRHGQTVLTASGEGEILSGTFSPT
LGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD

Sequences:

>Translated_369_residues
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVREFLRYLLANSVDKLKVS
GKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREKDLQWIGEQAARFDVRVEERSDFAMIAVQGPGARTKVIDLL
DPADTAAASKLGRFAALQTRSRDGIDLFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLEYQKAQGAPRQLIGVVMDEKGVLRHGQTVLTASGEGEILSGTFSPT
LGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD
>Mature_368_residues
TQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGARVREFLRYLLANSVDKLKVSG
KALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREKDLQWIGEQAARFDVRVEERSDFAMIAVQGPGARTKVIDLLD
PADTAAASKLGRFAALQTRSRDGIDLFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNLY
GQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLEYQKAQGAPRQLIGVVMDEKGVLRHGQTVLTASGEGEILSGTFSPTL
GKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDGQAQPGVLGD

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=375, Percent_Identity=34.9333333333333, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI257796258, Length=345, Percent_Identity=35.0724637681159, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI257796254, Length=370, Percent_Identity=31.8918918918919, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI24797151, Length=337, Percent_Identity=30.2670623145401, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI257796256, Length=287, Percent_Identity=35.8885017421603, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI197927446, Length=344, Percent_Identity=28.1976744186047, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI21361378, Length=344, Percent_Identity=28.1976744186047, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI194306651, Length=314, Percent_Identity=24.203821656051, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1789272, Length=368, Percent_Identity=58.9673913043478, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17560118, Length=375, Percent_Identity=36.2666666666667, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI71994045, Length=348, Percent_Identity=26.7241379310345, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994052, Length=348, Percent_Identity=26.7241379310345, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI32563613, Length=338, Percent_Identity=24.2603550295858, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=382, Percent_Identity=35.6020942408377, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI20129441, Length=378, Percent_Identity=33.8624338624339, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28571104, Length=268, Percent_Identity=27.6119402985075, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20130091, Length=386, Percent_Identity=25.1295336787565, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40368; Mature: 40236

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGA
CCCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEECCEEEEECCCH
RVREFLRYLLANSVDKLKVSGKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREK
HHHHHHHHHHHCCCHHEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQWIGEQAARFDVRVEERSDFAMIAVQGPGARTKVIDLLDPADTAAASKLGRFAALQTR
HHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
SRDGIDLFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
CCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLEYQKAQGAPRQLIGVVMDEKGVLRHG
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHEEEECCCCHHHCC
QTVLTASGEGEILSGTFSPTLGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDG
CEEEEECCCCCEEECCCCCHHHHHHHEEECCCCCHHHEEEEECCCCCCHHEEECCCEECC
QAQPGVLGD
CCCCCCCCC
>Mature Secondary Structure 
TQKTILNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHQVRRDAGMFDVSHMTVVDLHGA
CCCCCCCHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEECCEEEEECCCH
RVREFLRYLLANSVDKLKVSGKALYTCMLNPQGGVIDDLIVYYMTEDFFRLVVNAATREK
HHHHHHHHHHHCCCHHEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQWIGEQAARFDVRVEERSDFAMIAVQGPGARTKVIDLLDPADTAAASKLGRFAALQTR
HHHHHHHHHHEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
SRDGIDLFLARTGYTGEDGFEIVLPQEAAVAFWNALLAQGVKPAGLGARDTLRLEAGMNL
CCCCEEEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
YGQDMDDGVTPYEAGLAWTIALDEGRDFIGRSVLEYQKAQGAPRQLIGVVMDEKGVLRHG
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHEEEECCCCHHHCC
QTVLTASGEGEILSGTFSPTLGKAIAFARVPAGSIEQLRVDIRGKQVPLRAVKFPFVRDG
CEEEEECCCCCEEECCCCCHHHHHHHEEECCCCCHHHEEEEECCCCCCHHEEECCCEECC
QAQPGVLGD
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]