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The map label for this gene is cls [H]

Identifier: 78048582

GI number: 78048582

Start: 3444549

End: 3446060

Strand: Reverse

Name: cls [H]

Synonym: XCV3026

Alternate gene names: 78048582

Gene position: 3446060-3444549 (Counterclockwise)

Preceding gene: 78048583

Following gene: 162138532

Centisome position: 66.55

GC content: 65.67

Gene sequence:

>1512_bases
GTGCTGGCCAGCGCGTTATCGCTGTACGGCTACGGGCGCTTTGCCGACCGTCAACGCGGGCCGGTCAGTCACGTGCTGCC
TGCCACGGCGGTGGCGACGCCCATCGACAAGGTGGTGGCGCCACTGCAACAGGCGCACGCCGATCAGACCGGCATGGTGA
TCCTGCCGGATAACGTCGATGCGTTTGCGGTACGTGCGCTCACCGCGCGTGCGGCCGGGCGCAGCCTGGATCTGCAGTAC
TACATCTGGCATGCCGATTTCGCCGGCAACCTGCTGCATAACGAATTGCTGCGCGCGGCCGATCGCGGCGTACGCGTGCG
GTTGTTGCTGGACGACATGAATATCCATGGCAGCGATTCGGTGCTGGCTGCCCTGGATAGCCATCCGCTGATCGAGATTC
GCCTGTTCAACCCCACGCGCGCGCGAGAAGGCACCTTGATGCGTGGGGTGGAGATGGTGCTGCGCATGCTCAGCATCAAT
CGCCGCATGCACAACAAGGCCTGGATTGCCGATGGCCGCATCGCGGTGGTGGGTGGGCGCAACGTGGGCGACGAATATTT
CGATGCGGCGCGCGACACCAACTTCATGGATATGGATGCGGCGCTGATGGGGCCTGCGGTGGGCCAGGCCGAGCAGGTGT
TCGACGCGTACTGGAACAGCCCCAATGCCTTGCCGCTGTCTGCGCTGGTCACCGCAAAGCCGCAGGCACTGGAGGCCTTG
CGTGGCAGCCTTGACGCGGGCATGGCATCGGTGCGCGCGCATCCGTATGTGGAGCGGCTCAAGCGCTCGCCAAGCGTGCG
TGAACTGATGCAGGGCGACCGACCGGTGCACTGGGTGTCGCAGGCGCGCACCGTCTCCGACCCGCCGGAAAAAGCCGAAG
GTGCGCCGCCGCAAGCCGACTGGATGACGCCGGTGCTGATCGGCGAAATGGCGCACGCACAGCGCGAGCTCAAAGTGATC
TCGCCATATTTCGTGCCGGGCGACGAGGGCATGCGCTGGATCGGCAACCTACGCCAGCGCGATGTGCGCGTGAGCATTCT
GACCAACTCGCTGGCGGCCAACGACGTGGTGGCCGTGCACAGCGGCTATGCCGGCTATCGCGTGCCGCTGCTGCAGCAGG
GCGTGCGCCTGCATGAGCTCAAGCCGATGGGCAAGCCGGACGGCAGCCTGTTCGGTTCAAGCGGCGCCAGCCTGCATACC
AAGGCGTTTGTCGTGGACGACAGCAGCGGTTTCATCGGCTCGTTCAACCTGGACCCGCGTTCGATGAACCTCAATACCGA
AATGGGCCTGTTGTTCAACGACCGAGTGGTCACCGCGGAGCTGGAGCGGCTGTACAACCACAAGATCAGTGCGCCGGTGA
GTTACCGCGTGACCCTGGAGCAGGGCGAGCTGCGTTGGCACGACGATGCCGCGCAGCCGCCCGAGGTGTGGTCGCGCGAG
CCGGCGGCGAGCGTGTGGCGACGTGGCGCAGCAGCGGTGATGGGCTGGTTGCCGCTGGAGTCGCAGCTGTAG

Upstream 100 bases:

>100_bases
TGCCCGCGTGGGCTCTACACTGCCGCGCTGCGCATCGCGGAATCGGCAGTGACAAAGCGGAAATTTTTTCAAATGGTTCG
GCATTGCGCTGCTGGTACTG

Downstream 100 bases:

>100_bases
CTGGCTGGTTAGCGTGTTGCCCTCATCCGCCCTTCGGGCACCTTCTCCCGCCGGCGGGAGAAGGGAATGTGGCGGTCTTT
CATGGATAGGAGAATGCGCG

Product: cardiolipin synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MLASALSLYGYGRFADRQRGPVSHVLPATAVATPIDKVVAPLQQAHADQTGMVILPDNVDAFAVRALTARAAGRSLDLQY
YIWHADFAGNLLHNELLRAADRGVRVRLLLDDMNIHGSDSVLAALDSHPLIEIRLFNPTRAREGTLMRGVEMVLRMLSIN
RRMHNKAWIADGRIAVVGGRNVGDEYFDAARDTNFMDMDAALMGPAVGQAEQVFDAYWNSPNALPLSALVTAKPQALEAL
RGSLDAGMASVRAHPYVERLKRSPSVRELMQGDRPVHWVSQARTVSDPPEKAEGAPPQADWMTPVLIGEMAHAQRELKVI
SPYFVPGDEGMRWIGNLRQRDVRVSILTNSLAANDVVAVHSGYAGYRVPLLQQGVRLHELKPMGKPDGSLFGSSGASLHT
KAFVVDDSSGFIGSFNLDPRSMNLNTEMGLLFNDRVVTAELERLYNHKISAPVSYRVTLEQGELRWHDDAAQPPEVWSRE
PAASVWRRGAAAVMGWLPLESQL

Sequences:

>Translated_503_residues
MLASALSLYGYGRFADRQRGPVSHVLPATAVATPIDKVVAPLQQAHADQTGMVILPDNVDAFAVRALTARAAGRSLDLQY
YIWHADFAGNLLHNELLRAADRGVRVRLLLDDMNIHGSDSVLAALDSHPLIEIRLFNPTRAREGTLMRGVEMVLRMLSIN
RRMHNKAWIADGRIAVVGGRNVGDEYFDAARDTNFMDMDAALMGPAVGQAEQVFDAYWNSPNALPLSALVTAKPQALEAL
RGSLDAGMASVRAHPYVERLKRSPSVRELMQGDRPVHWVSQARTVSDPPEKAEGAPPQADWMTPVLIGEMAHAQRELKVI
SPYFVPGDEGMRWIGNLRQRDVRVSILTNSLAANDVVAVHSGYAGYRVPLLQQGVRLHELKPMGKPDGSLFGSSGASLHT
KAFVVDDSSGFIGSFNLDPRSMNLNTEMGLLFNDRVVTAELERLYNHKISAPVSYRVTLEQGELRWHDDAAQPPEVWSRE
PAASVWRRGAAAVMGWLPLESQL
>Mature_503_residues
MLASALSLYGYGRFADRQRGPVSHVLPATAVATPIDKVVAPLQQAHADQTGMVILPDNVDAFAVRALTARAAGRSLDLQY
YIWHADFAGNLLHNELLRAADRGVRVRLLLDDMNIHGSDSVLAALDSHPLIEIRLFNPTRAREGTLMRGVEMVLRMLSIN
RRMHNKAWIADGRIAVVGGRNVGDEYFDAARDTNFMDMDAALMGPAVGQAEQVFDAYWNSPNALPLSALVTAKPQALEAL
RGSLDAGMASVRAHPYVERLKRSPSVRELMQGDRPVHWVSQARTVSDPPEKAEGAPPQADWMTPVLIGEMAHAQRELKVI
SPYFVPGDEGMRWIGNLRQRDVRVSILTNSLAANDVVAVHSGYAGYRVPLLQQGVRLHELKPMGKPDGSLFGSSGASLHT
KAFVVDDSSGFIGSFNLDPRSMNLNTEMGLLFNDRVVTAELERLYNHKISAPVSYRVTLEQGELRWHDDAAQPPEVWSRE
PAASVWRRGAAAVMGWLPLESQL

Specific function: Unknown

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI87081826, Length=469, Percent_Identity=39.6588486140725, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1787502, Length=427, Percent_Identity=23.6533957845433, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 55306; Mature: 55306

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLASALSLYGYGRFADRQRGPVSHVLPATAVATPIDKVVAPLQQAHADQTGMVILPDNVD
CCCCHHHHHCCCCCCCCCCCCHHHHCCHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCC
AFAVRALTARAAGRSLDLQYYIWHADFAGNLLHNELLRAADRGVRVRLLLDDMNIHGSDS
HHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
VLAALDSHPLIEIRLFNPTRAREGTLMRGVEMVLRMLSINRRMHNKAWIADGRIAVVGGR
EEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECC
NVGDEYFDAARDTNFMDMDAALMGPAVGQAEQVFDAYWNSPNALPLSALVTAKPQALEAL
CCCHHHHHHHCCCCCEECCHHHHCCCCCHHHHHHHHHCCCCCCCEEHHEECCCHHHHHHH
RGSLDAGMASVRAHPYVERLKRSPSVRELMQGDRPVHWVSQARTVSDPPEKAEGAPPQAD
HHHHHHHHHHHHCCHHHHHHHCCCCHHHHHCCCCCEEHHHHCCCCCCCCHHCCCCCCCCC
WMTPVLIGEMAHAQRELKVISPYFVPGDEGMRWIGNLRQRDVRVSILTNSLAANDVVAVH
CCCHHHHHHHHHHHHHHEEECCEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCCEEEEE
SGYAGYRVPLLQQGVRLHELKPMGKPDGSLFGSSGASLHTKAFVVDDSSGFIGSFNLDPR
CCCCCEECHHHHCCCEEECCCCCCCCCCCEECCCCCCEEEEEEEEECCCCCEEEECCCCC
SMNLNTEMGLLFNDRVVTAELERLYNHKISAPVSYRVTLEQGELRWHDDAAQPPEVWSRE
CCCCCCCCCEEECCEEHHHHHHHHHCCCCCCCEEEEEEEECCCEEECCCCCCCCHHHCCC
PAASVWRRGAAAVMGWLPLESQL
HHHHHHHCCHHHHHEECCCCCCC
>Mature Secondary Structure
MLASALSLYGYGRFADRQRGPVSHVLPATAVATPIDKVVAPLQQAHADQTGMVILPDNVD
CCCCHHHHHCCCCCCCCCCCCHHHHCCHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCC
AFAVRALTARAAGRSLDLQYYIWHADFAGNLLHNELLRAADRGVRVRLLLDDMNIHGSDS
HHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
VLAALDSHPLIEIRLFNPTRAREGTLMRGVEMVLRMLSINRRMHNKAWIADGRIAVVGGR
EEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECC
NVGDEYFDAARDTNFMDMDAALMGPAVGQAEQVFDAYWNSPNALPLSALVTAKPQALEAL
CCCHHHHHHHCCCCCEECCHHHHCCCCCHHHHHHHHHCCCCCCCEEHHEECCCHHHHHHH
RGSLDAGMASVRAHPYVERLKRSPSVRELMQGDRPVHWVSQARTVSDPPEKAEGAPPQAD
HHHHHHHHHHHHCCHHHHHHHCCCCHHHHHCCCCCEEHHHHCCCCCCCCHHCCCCCCCCC
WMTPVLIGEMAHAQRELKVISPYFVPGDEGMRWIGNLRQRDVRVSILTNSLAANDVVAVH
CCCHHHHHHHHHHHHHHEEECCEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCCEEEEE
SGYAGYRVPLLQQGVRLHELKPMGKPDGSLFGSSGASLHTKAFVVDDSSGFIGSFNLDPR
CCCCCEECHHHHCCCEEECCCCCCCCCCCEECCCCCCEEEEEEEEECCCCCEEEECCCCC
SMNLNTEMGLLFNDRVVTAELERLYNHKISAPVSYRVTLEQGELRWHDDAAQPPEVWSRE
CCCCCCCCCEEECCEEHHHHHHHHHCCCCCCCEEEEEEEECCCEEECCCCCCCCHHHCCC
PAASVWRRGAAAVMGWLPLESQL
HHHHHHHCCHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]