Click here to switch to the map view.

The map label for this gene is dctA2 [H]

Identifier: 78048468

GI number: 78048468

Start: 3312886

End: 3314256

Strand: Reverse

Name: dctA2 [H]

Synonym: XCV2912

Alternate gene names: 78048468

Gene position: 3314256-3312886 (Counterclockwise)

Preceding gene: 78048473

Following gene: 78048467

Centisome position: 64.0

GC content: 63.31

Gene sequence:

>1371_bases
ATGCACTTTCCCCCCGGAAGATTCGACGACATGAAACTGGTTGCGGCGTGGTTGCGCATTCCGTTCTGGCAACGCGTGGT
GGCCGGCTTCGTCCTCGGCGCGCTGGTCGGCTGGGCCATGGGTCCGGCGGCCGATGTGTGGTTCGGTCCGTTGGGTGACC
TGTACGTCACGTTGATCAAGATGATCGCCATCCCGCTGGTGTTCTTCGCGGTGATCAATGCGATCTCGTCCTTGCACGGG
CAAAAGTCGGTTGCCGCACTCGGTGGACGCACGTTTTTATGGTTTGTCATCACCGCAGCATTGGCGGTGGGCGTGGGCCT
GGCGGTCGGCACGATCATGCAGCCGGGCGCCGGCCATTTCAGTCTGAGCGTGGATTCGGCCTGGAAGCCGCGCGATGTGC
CAAGCCCGGTCCAGGTGCTGCTGGATGTGGTGCCGTCCAATCCGTTCTACGCACTGACCGGCATCGGCACCAAGACCAAC
GCGGCCGGCGAAACGGTGCTGGCGGCGGGGCGTGGCTCGATCCTGCCGGTGATCTTCTTCGCCGCGTTGCTGGGCTTTGC
AATGGTCAAGCTCGGCGAGCGGGTGGCCGAGGCGCGCAAGCTCACCGGGCAGATGAGCGACATCATGATTCAGGTGACGC
GCTTCGTGCTGGAAATGACTCCGCTCGGCACCTTTGGCCTGATCGCTGGCCTGGTCGGCAGCTACGGCTTTTCGAAACTG
CTGCCGTTCGGCAATTTCGTCCTGGCGCTGTATGTGGCCTGCGCGATCCACATTGTGGTGGTCTACAGCAGCCTGTTGCT
CGCACATGGGCTGAACCCGTGGAAGTTTTTCCGCGGTGCCGCGCCTGGCATGCAGGTGGCGTTCGTCAGTTCGTCGAGCT
TTGCGGCAATGCCGGTGGCAATGCGTTCGATCACGCATAACCTGGGGGTCAGCAAGGATTACGCCGCATTCGCGGTACCG
CTGGGCGCCAGCATCAAGATGGATGGCTGCGGCGCGATCTTTCCGGCGTTATGCGCGGTGTTCATCGCGCAATACACCGG
CGTGCCGCTGACCGCCAACCAGTATTTCGTGGTGCTGATCGCCTCGGTGCTCGGCAGCTTCGGCACGGCCGGCGTACCGG
GCACGGCCGTCATCATGGCGACGGTGGTGCTGAGTGCGGCCAATCTGCCGCTGGAAGTGATCGGCTACCTGTATGCGATC
GACCGCATCCTGGACATGATGCGCACCATGACCAATGTCACCGGGCAGATGCTGGTGCCGGTGCTGGTGGCCAAGGAGAC
CGGACTGCTCGACAAGCGCATCTACGACTCCGCCTCCACCAATGTGGGGCTGGAAGAACCGCCGGCCGACAGCGCCAGAC
CACTGCGCTGA

Upstream 100 bases:

>100_bases
GAATCAATCCCCATTATGCCGCGCTGGGTGGTGTCACACCGATGACACAGCGCTGTTCCAGCGGTGGTCTCGCGGGCAGG
GCAGCCCTGGGCTATGGTGC

Downstream 100 bases:

>100_bases
GGCGGCTTGATGCGTGCCGGATCTCCACTCCTGCGCGAACGGCTGCAGCAGCTGCCCGAGCTGCAGCGCATGGATGGCGT
GTTCGTGCAGCGCGGCTTGG

Product: glutamate/aspartate:cation symporter family protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MHFPPGRFDDMKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFAVINAISSLHG
QKSVAALGGRTFLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTN
AAGETVLAAGRGSILPVIFFAALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKL
LPFGNFVLALYVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVSKDYAAFAVP
LGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAI
DRILDMMRTMTNVTGQMLVPVLVAKETGLLDKRIYDSASTNVGLEEPPADSARPLR

Sequences:

>Translated_456_residues
MHFPPGRFDDMKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFAVINAISSLHG
QKSVAALGGRTFLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTN
AAGETVLAAGRGSILPVIFFAALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKL
LPFGNFVLALYVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVSKDYAAFAVP
LGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAI
DRILDMMRTMTNVTGQMLVPVLVAKETGLLDKRIYDSASTNVGLEEPPADSARPLR
>Mature_456_residues
MHFPPGRFDDMKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIKMIAIPLVFFAVINAISSLHG
QKSVAALGGRTFLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTN
AAGETVLAAGRGSILPVIFFAALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKL
LPFGNFVLALYVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVSKDYAAFAVP
LGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAI
DRILDMMRTMTNVTGQMLVPVLVAKETGLLDKRIYDSASTNVGLEEPPADSARPLR

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=393, Percent_Identity=27.4809160305344, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI40254478, Length=465, Percent_Identity=25.5913978494624, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI5032093, Length=382, Percent_Identity=28.2722513089005, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI66773030, Length=265, Percent_Identity=31.6981132075472, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI169790839, Length=455, Percent_Identity=25.4945054945055, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI194239697, Length=449, Percent_Identity=24.4988864142539, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI223468564, Length=292, Percent_Identity=28.7671232876712, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI223468566, Length=292, Percent_Identity=28.7671232876712, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI4827012, Length=461, Percent_Identity=24.9457700650759, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI301601644, Length=151, Percent_Identity=35.7615894039735, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI262359914, Length=395, Percent_Identity=23.7974683544304, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1789947, Length=433, Percent_Identity=29.0993071593533, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790514, Length=421, Percent_Identity=29.4536817102138, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788024, Length=413, Percent_Identity=32.4455205811138, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1789473, Length=417, Percent_Identity=23.9808153477218, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71983099, Length=460, Percent_Identity=26.5217391304348, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17537407, Length=429, Percent_Identity=28.4382284382284, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=447, Percent_Identity=26.8456375838926, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=446, Percent_Identity=27.8026905829596, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71996953, Length=442, Percent_Identity=24.2081447963801, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193206654, Length=422, Percent_Identity=24.6445497630332, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=401, Percent_Identity=23.4413965087282, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24583025, Length=428, Percent_Identity=24.5327102803738, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137668, Length=428, Percent_Identity=24.5327102803738, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24583023, Length=428, Percent_Identity=24.5327102803738, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360481, Length=470, Percent_Identity=25.3191489361702, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281360483, Length=470, Percent_Identity=25.3191489361702, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137666, Length=470, Percent_Identity=25.3191489361702, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48120; Mature: 48120

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFPPGRFDDMKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIK
CCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHH
MIAIPLVFFAVINAISSLHGQKSVAALGGRTFLWFVITAALAVGVGLAVGTIMQPGAGHF
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
SLSVDSAWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTNAAGETVLAAGRGSILPVIFF
EEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHH
AALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHH
LPFGNFVLALYVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHH
MRSITHNLGVSKDYAAFAVPLGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLI
HHHHHHHCCCCCCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAIDRILDMMRTMTNVTGQMLVP
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVAKETGLLDKRIYDSASTNVGLEEPPADSARPLR
HHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHFPPGRFDDMKLVAAWLRIPFWQRVVAGFVLGALVGWAMGPAADVWFGPLGDLYVTLIK
CCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHH
MIAIPLVFFAVINAISSLHGQKSVAALGGRTFLWFVITAALAVGVGLAVGTIMQPGAGHF
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
SLSVDSAWKPRDVPSPVQVLLDVVPSNPFYALTGIGTKTNAAGETVLAAGRGSILPVIFF
EEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHH
AALLGFAMVKLGERVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHH
LPFGNFVLALYVACAIHIVVVYSSLLLAHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHH
MRSITHNLGVSKDYAAFAVPLGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLI
HHHHHHHCCCCCCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ASVLGSFGTAGVPGTAVIMATVVLSAANLPLEVIGYLYAIDRILDMMRTMTNVTGQMLVP
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVAKETGLLDKRIYDSASTNVGLEEPPADSARPLR
HHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA