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The map label for this gene is argB [H]

Identifier: 78048103

GI number: 78048103

Start: 2874452

End: 2875732

Strand: Reverse

Name: argB [H]

Synonym: XCV2547

Alternate gene names: 78048103

Gene position: 2875732-2874452 (Counterclockwise)

Preceding gene: 78048104

Following gene: 78048102

Centisome position: 55.53

GC content: 62.61

Gene sequence:

>1281_bases
ATGGCCAGCGCGAAGGAAATCAGCCAATACCTCAAGCGGTTTTCGCAGCTCGATGCCAAGCGCTTTGCGGTGGTCAAGGT
GGGGGGCGCGGTGTTGCGCGACGATCTGGACGCGCTGACCTCGTCGTTGTCGTTCCTGCAGGAAGTTGGGCTGACCCCGA
TCGTGCTGCATGGCGCCGGCCCGCAGCTGGATGCAGAGCTGGCCGCCGCCGGTATCGAAAAGCACACCGTCAACGGACTG
CGCGTGACCTCGCCCGAAGCCTTGGCGATCGTGCGCAAGGTGTTCCAGGCCTCCAACCTGAAACTGGTGGAAGCGCTGCA
GCAAAACGGCGCGCGTGCGACCTCGATCACCGGTGGCGTGTTCGAGGCCGAGTATCTGGATCGCGACACCTACGGCCTGG
TCGGTGAGGTCAAGGCGGTGAATCTGGCGCCGATCGAAGCCAGTCTGCAGGCCGGCTCCATCCCGGTGATCACCAGCCTG
GGCGAAACGCCCAGCGGGCAGATCCTCAACGTCAATGCGGATTTTGCCGCCAACGAGTTGGTGCAGGAGCTGCAGCCGTA
CAAGATCATCTTTCTCACCGGCACCGGCGGCCTGCTGGATGCCGATGGCAAGTTGATCGATTCGATCAACCTGTCTACCG
AGTTCGACCACCTGATGCAGCAGCCGTGGATCAACGGCGGCATGCGGGTGAAGATCGAGCAGATCAAGGACTTGCTCGAT
CGCCTGCCGCTGGAATCGTCGGTGTCGATCACCCGGCCGTCGGACCTGGCCAAGGAGCTGTTCACCCACAAGGGCTCGGG
TACGCTGGTGCGGCGCGGCGAGCGCGTGCTGCGCGCCACCTCCTGGGACGAACTGGATCTGCCTCGCCTGAAGTCGCTGA
TCGAATCCAGCTTCGGCCGCACGCTGGTGCCGGAGTATTTCGAGACCACCACGTTGCTGCGCGCGTATGTCAGCGAAAAC
TACCGCGCGGCGGTGATCCTGACCGACGAAGGCCAGTTCGGTGCGGGCAGGCTGACCTATCTGGACAAGTTCGCCGTGCT
CGACGATGCGCAGGGCGAAGGTCTTGGCCGGGCGGTATGGAATGTGATGCGCGAAGAGACCCCGCAGCTGTTCTGGCGCT
CGCGCCATAACAACCAGGTCAATATCTTTTACTACGCCGAATCCGACGGTTGCATCAAGCAGGAGAAGTGGAAGGTGTTC
TGGTACGGGCTGGAAAACTTCGAGCAGATCCAGCATTGCGTTGCGCACTGCGCGACGCGTCAGCCGACCTTGCTGGGCTG
A

Upstream 100 bases:

>100_bases
CGCGCCTGGCGCTCCCTTTCCTCTTTCGAACACGGCAATGTCCCCTTCCGCACAACCCCACAAACAAACCCGCCAGACCA
TCGTGCGCCTGCTCTCCAGC

Downstream 100 bases:

>100_bases
CTGCGATGAGCGTCGTCACCTTGCCAGCACGTTGGCGCGAGCAGCCGAACATGCGTGGACGGCATGCGAGCCTGGAGCCG
CTGCAGACAGCGCATGCCGA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGAGPQLDAELAAAGIEKHTVNGL
RVTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLDRDTYGLVGEVKAVNLAPIEASLQAGSIPVITSL
GETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLMQQPWINGGMRVKIEQIKDLLD
RLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFGRTLVPEYFETTTLLRAYVSEN
YRAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKVF
WYGLENFEQIQHCVAHCATRQPTLLG

Sequences:

>Translated_426_residues
MASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGAGPQLDAELAAAGIEKHTVNGL
RVTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLDRDTYGLVGEVKAVNLAPIEASLQAGSIPVITSL
GETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLMQQPWINGGMRVKIEQIKDLLD
RLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFGRTLVPEYFETTTLLRAYVSEN
YRAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKVF
WYGLENFEQIQHCVAHCATRQPTLLG
>Mature_425_residues
ASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGAGPQLDAELAAAGIEKHTVNGLR
VTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLDRDTYGLVGEVKAVNLAPIEASLQAGSIPVITSLG
ETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLMQQPWINGGMRVKIEQIKDLLDR
LPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFGRTLVPEYFETTTLLRAYVSENY
RAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKVFW
YGLENFEQIQHCVAHCATRQPTLLG

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the acetylglutamate kinase family [H]

Homologues:

Organism=Homo sapiens, GI23308587, Length=422, Percent_Identity=34.8341232227488, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1789181, Length=284, Percent_Identity=22.5352112676056, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693208, Length=241, Percent_Identity=27.3858921161826, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320913, Length=433, Percent_Identity=41.3394919168591, Blast_Score=328, Evalue=1e-90,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011242
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR006855 [H]

Pfam domain/function: PF00696 AA_kinase; PF04768 DUF619 [H]

EC number: =2.7.2.8 [H]

Molecular weight: Translated: 47028; Mature: 46897

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGAG
CCCHHHHHHHHHHHHHCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
PQLDAELAAAGIEKHTVNGLRVTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGV
CCCCHHHHHHCCHHHCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCC
FEAEYLDRDTYGLVGEVKAVNLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANEL
EEHHHHCCCCCCCCCCEEEEEEECCHHCCCCCCCCEEEECCCCCCCCEEEECCCHHHHHH
VQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLMQQPWINGGMRVKIEQIKDLLD
HHHCCCEEEEEEECCCCEEECCCCEEEECCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHH
RLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFGR
HCCCCCCCEECCHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHCCC
TLVPEYFETTTLLRAYVSENYRAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVW
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
NVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATR
HHHHHHCHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCC
QPTLLG
CCCCCC
>Mature Secondary Structure 
ASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLDALTSSLSFLQEVGLTPIVLHGAG
CCHHHHHHHHHHHHHCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
PQLDAELAAAGIEKHTVNGLRVTSPEALAIVRKVFQASNLKLVEALQQNGARATSITGGV
CCCCHHHHHHCCHHHCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCC
FEAEYLDRDTYGLVGEVKAVNLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANEL
EEHHHHCCCCCCCCCCEEEEEEECCHHCCCCCCCCEEEECCCCCCCCEEEECCCHHHHHH
VQELQPYKIIFLTGTGGLLDADGKLIDSINLSTEFDHLMQQPWINGGMRVKIEQIKDLLD
HHHCCCEEEEEEECCCCEEECCCCEEEECCCCHHHHHHHHCCCCCCCCEEEHHHHHHHHH
RLPLESSVSITRPSDLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLKSLIESSFGR
HCCCCCCCEECCHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHCCC
TLVPEYFETTTLLRAYVSENYRAAVILTDEGQFGAGRLTYLDKFAVLDDAQGEGLGRAVW
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
NVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATR
HHHHHHCHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCC
QPTLLG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]