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The map label for this gene is purR [H]

Identifier: 78048067

GI number: 78048067

Start: 2836361

End: 2837383

Strand: Reverse

Name: purR [H]

Synonym: XCV2511

Alternate gene names: 78048067

Gene position: 2837383-2836361 (Counterclockwise)

Preceding gene: 78048068

Following gene: 78048066

Centisome position: 54.79

GC content: 69.7

Gene sequence:

>1023_bases
ATGGCCAAGGGTGCGGTCACCATCAAAGATGTCGCTCGGGAAGCGCAGGTCTCCGTCGCAACGGTGTCGCGTGCGCTCAA
CGGGCACGACAACGTTGCCGGACCGGTGCGCCAGCAGGTGCTGGAGGTGGCCGAGCGGCTGCGCTACAGCCCGCATGCGG
CCGCGCGCAGCCTGAGCAGCCGGCGCTCGCAGACCCTGGGCGTGGTGCTGCCGGACTTGTATGGCGAGTTCTTTTCCGAA
TTGATTCGCGGCATCGACGGCGCGGCGCGTGCGGCCGGCCAGCACCTGCTGGTGTCCAGCTACCACGGCGACCCGGAAGC
CCAGGGCAGGGCGCTGCGCTCGATGCGCGGGCGCGTCGATGGCCTGCTGGTGCTTTCGCCCTACGCCGAGCAGCCGGGGT
TCCTCACCGACAACCTGCCGCAGTCGCTGCCGACGGTGTTGATCAATGCGCACCTGCCCGGTGCCGACTATCCGGTGCTG
AGCATCGACGACCATGCCGGTGCCATGGCCATGACCGAGCACCTGTTGCGGGCCGGGCACCGCCGCATCGCCTTCATCGG
TGGCCCGGCGCTGAACTTCGATGCGCGCGAACGCCTGCGCGGCTTCCGCGATGCGCTTGCTGCGTTCGGTGCGCAGGCGC
AGGGCGTGGAATACCCGGGCGACTTCGACGAAGCCTCCGGCCACCGCGCCGGGCTGGCGATGCTGGCGGCCGGCGCGTTG
CCGGATGCGGTGTTCGCCGCCAACGACATGACCGCGCTGGGCTGCCTGTACGCGTTTGCCCAGGCCGATGTGTCGGTGCC
TGGCGACGTGGCGCTGGCGGGTTTTGACGACATTCCGCTGGCCCGCTTTGTCCATCCCGCGCTGACCACCATGCGGGTGA
GCATCGCCCGGCTGGGCGAGCAGGCGATGACCCGGCTGATGCGCCTGGTCGAAACGCCTGACCGCGATGACGGCATCCGC
CAGTTGCTGACGCCCGAGCTGGTGATCCGTGCCTCCTGCGGTGCCGGCCAATCGGCTCACTGA

Upstream 100 bases:

>100_bases
AAGCGTTTTCACGCATGTGAAGATAGGGGTTTACGCCTCTGTATGAAAACGCTTACAGTCCGCGCCAGTTTTGGGAAGGC
GGTCGCGGAGGGCGACACGA

Downstream 100 bases:

>100_bases
CCTTTCCGGCCACGCGTTTCCGGGCCGACCTTTTCGCGGACGTCCTGTCCGCTCCCGCTGTCCCCGCAGCGGCTGTTCCT
GCACCACTGCACTGCCACAA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAKGAVTIKDVAREAQVSVATVSRALNGHDNVAGPVRQQVLEVAERLRYSPHAAARSLSSRRSQTLGVVLPDLYGEFFSE
LIRGIDGAARAAGQHLLVSSYHGDPEAQGRALRSMRGRVDGLLVLSPYAEQPGFLTDNLPQSLPTVLINAHLPGADYPVL
SIDDHAGAMAMTEHLLRAGHRRIAFIGGPALNFDARERLRGFRDALAAFGAQAQGVEYPGDFDEASGHRAGLAMLAAGAL
PDAVFAANDMTALGCLYAFAQADVSVPGDVALAGFDDIPLARFVHPALTTMRVSIARLGEQAMTRLMRLVETPDRDDGIR
QLLTPELVIRASCGAGQSAH

Sequences:

>Translated_340_residues
MAKGAVTIKDVAREAQVSVATVSRALNGHDNVAGPVRQQVLEVAERLRYSPHAAARSLSSRRSQTLGVVLPDLYGEFFSE
LIRGIDGAARAAGQHLLVSSYHGDPEAQGRALRSMRGRVDGLLVLSPYAEQPGFLTDNLPQSLPTVLINAHLPGADYPVL
SIDDHAGAMAMTEHLLRAGHRRIAFIGGPALNFDARERLRGFRDALAAFGAQAQGVEYPGDFDEASGHRAGLAMLAAGAL
PDAVFAANDMTALGCLYAFAQADVSVPGDVALAGFDDIPLARFVHPALTTMRVSIARLGEQAMTRLMRLVETPDRDDGIR
QLLTPELVIRASCGAGQSAH
>Mature_339_residues
AKGAVTIKDVAREAQVSVATVSRALNGHDNVAGPVRQQVLEVAERLRYSPHAAARSLSSRRSQTLGVVLPDLYGEFFSEL
IRGIDGAARAAGQHLLVSSYHGDPEAQGRALRSMRGRVDGLLVLSPYAEQPGFLTDNLPQSLPTVLINAHLPGADYPVLS
IDDHAGAMAMTEHLLRAGHRRIAFIGGPALNFDARERLRGFRDALAAFGAQAQGVEYPGDFDEASGHRAGLAMLAAGALP
DAVFAANDMTALGCLYAFAQADVSVPGDVALAGFDDIPLARFVHPALTTMRVSIARLGEQAMTRLMRLVETPDRDDGIRQ
LLTPELVIRASCGAGQSAH

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=328, Percent_Identity=35.6707317073171, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=34.5345345345345, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1790369, Length=337, Percent_Identity=33.5311572700297, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788474, Length=343, Percent_Identity=32.6530612244898, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1787948, Length=336, Percent_Identity=33.6309523809524, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789068, Length=319, Percent_Identity=30.4075235109718, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1786540, Length=308, Percent_Identity=29.8701298701299, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787580, Length=314, Percent_Identity=28.343949044586, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI48994940, Length=315, Percent_Identity=28.8888888888889, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789456, Length=319, Percent_Identity=29.4670846394984, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787906, Length=307, Percent_Identity=27.0358306188925, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790715, Length=311, Percent_Identity=23.1511254019293, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786268, Length=285, Percent_Identity=22.8070175438596, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790689, Length=307, Percent_Identity=22.8013029315961, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36114; Mature: 35982

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKGAVTIKDVAREAQVSVATVSRALNGHDNVAGPVRQQVLEVAERLRYSPHAAARSLSS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
RRSQTLGVVLPDLYGEFFSELIRGIDGAARAAGQHLLVSSYHGDPEAQGRALRSMRGRVD
HHHHHHHEECHHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCC
GLLVLSPYAEQPGFLTDNLPQSLPTVLINAHLPGADYPVLSIDDHAGAMAMTEHLLRAGH
EEEEECCCCCCCCCCCCCCHHHHHHEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCC
RRIAFIGGPALNFDARERLRGFRDALAAFGAQAQGVEYPGDFDEASGHRAGLAMLAAGAL
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PDAVFAANDMTALGCLYAFAQADVSVPGDVALAGFDDIPLARFVHPALTTMRVSIARLGE
CHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QAMTRLMRLVETPDRDDGIRQLLTPELVIRASCGAGQSAH
HHHHHHHHHHCCCCCCHHHHHHHCHHHEEEECCCCCCCCC
>Mature Secondary Structure 
AKGAVTIKDVAREAQVSVATVSRALNGHDNVAGPVRQQVLEVAERLRYSPHAAARSLSS
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
RRSQTLGVVLPDLYGEFFSELIRGIDGAARAAGQHLLVSSYHGDPEAQGRALRSMRGRVD
HHHHHHHEECHHHHHHHHHHHHHCCCHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCC
GLLVLSPYAEQPGFLTDNLPQSLPTVLINAHLPGADYPVLSIDDHAGAMAMTEHLLRAGH
EEEEECCCCCCCCCCCCCCHHHHHHEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCC
RRIAFIGGPALNFDARERLRGFRDALAAFGAQAQGVEYPGDFDEASGHRAGLAMLAAGAL
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PDAVFAANDMTALGCLYAFAQADVSVPGDVALAGFDDIPLARFVHPALTTMRVSIARLGE
CHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
QAMTRLMRLVETPDRDDGIRQLLTPELVIRASCGAGQSAH
HHHHHHHHHHCCCCCCHHHHHHHCHHHEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA