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The map label for this gene is nfxB [H]

Identifier: 78047987

GI number: 78047987

Start: 2759066

End: 2759635

Strand: Reverse

Name: nfxB [H]

Synonym: XCV2431

Alternate gene names: 78047987

Gene position: 2759635-2759066 (Counterclockwise)

Preceding gene: 78047991

Following gene: 78047984

Centisome position: 53.29

GC content: 65.96

Gene sequence:

>570_bases
ATGAGCCAGGACGACCAACGCCTTATCCGCCTGCTGGCCGCAACGCTGACCCGCCGCCCACGCAGCAATCTCACCGAGCT
GGCCGGTGGCGCGGGGATCAGCCGCGCGACGCTGTACCGCTTTGCCCCGACCCGCGCGGCAATCGTGGAGAAGGTCACCG
CCGAAGCGTGGCTGCGTCTGCAGGCGGCCCTGCCCAACGATGCCCTGCCCGATCCCATGGCAAGCCTGCGACGCATGACG
CACGCCTTGGTGGAAGACCTGGATCTGGTCATCTACATCGTCAACGAGATGGGCATGGAGGGCGCCGAACGCGGCAACAC
CTATTACGCCGCGCCGGAGTGGGAGTCGTTCCAGGCGCATCTGGATGCTTTCTTCTTGCACGGCCAGCAGCGCGGCGTGT
TCGGTATCGAAATGCCGGCGTCCTGGTGGAGCGACTTCTACCTCTCGTGCCTGTTCGGAGCCGGTTGGGCAGTGGCCACC
GGCCGTCTGGCACAGGCATCGGTCGTGCGTGCGGTCCTGACCTCGTTCCTGGAAGGCGCACGTTCCGGTTCGAGAGTGCA
ATCTCCCTAG

Upstream 100 bases:

>100_bases
CGGCAATGATGCGCCATAGATCCTTATGAATCAAATATGATTCATAAGGATCATTTCCAAAGAACCTGTATCATCCCTGC
TTCACTCGTTTTTCAAGCGT

Downstream 100 bases:

>100_bases
CCGCGAGCCGCTGGCGCCGCCGTCACCGTCGCCACCAGCCGGAACACCACGCGATGTATCGCGTTTCCGCAGTTTGAGCG
ATCGGTTTTTATCGAGGCGG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MSQDDQRLIRLLAATLTRRPRSNLTELAGGAGISRATLYRFAPTRAAIVEKVTAEAWLRLQAALPNDALPDPMASLRRMT
HALVEDLDLVIYIVNEMGMEGAERGNTYYAAPEWESFQAHLDAFFLHGQQRGVFGIEMPASWWSDFYLSCLFGAGWAVAT
GRLAQASVVRAVLTSFLEGARSGSRVQSP

Sequences:

>Translated_189_residues
MSQDDQRLIRLLAATLTRRPRSNLTELAGGAGISRATLYRFAPTRAAIVEKVTAEAWLRLQAALPNDALPDPMASLRRMT
HALVEDLDLVIYIVNEMGMEGAERGNTYYAAPEWESFQAHLDAFFLHGQQRGVFGIEMPASWWSDFYLSCLFGAGWAVAT
GRLAQASVVRAVLTSFLEGARSGSRVQSP
>Mature_188_residues
SQDDQRLIRLLAATLTRRPRSNLTELAGGAGISRATLYRFAPTRAAIVEKVTAEAWLRLQAALPNDALPDPMASLRRMTH
ALVEDLDLVIYIVNEMGMEGAERGNTYYAAPEWESFQAHLDAFFLHGQQRGVFGIEMPASWWSDFYLSCLFGAGWAVATG
RLAQASVVRAVLTSFLEGARSGSRVQSP

Specific function: Confers resistance to guinolones. May negatively regulate the expression of genes that are associated with cell permeability to drugs [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR000843
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR005471 [H]

Pfam domain/function: PF09339 HTH_IclR [H]

EC number: NA

Molecular weight: Translated: 20818; Mature: 20687

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDDQRLIRLLAATLTRRPRSNLTELAGGAGISRATLYRFAPTRAAIVEKVTAEAWLRL
CCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
QAALPNDALPDPMASLRRMTHALVEDLDLVIYIVNEMGMEGAERGNTYYAAPEWESFQAH
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEECCCHHHHHHH
LDAFFLHGQQRGVFGIEMPASWWSDFYLSCLFGAGWAVATGRLAQASVVRAVLTSFLEGA
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHH
RSGSRVQSP
CCCCCCCCC
>Mature Secondary Structure 
SQDDQRLIRLLAATLTRRPRSNLTELAGGAGISRATLYRFAPTRAAIVEKVTAEAWLRL
CCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHH
QAALPNDALPDPMASLRRMTHALVEDLDLVIYIVNEMGMEGAERGNTYYAAPEWESFQAH
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEECCCHHHHHHH
LDAFFLHGQQRGVFGIEMPASWWSDFYLSCLFGAGWAVATGRLAQASVVRAVLTSFLEGA
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHH
RSGSRVQSP
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1330820; 10984043 [H]