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The map label for this gene is oprN6 [H]

Identifier: 78047662

GI number: 78047662

Start: 2411591

End: 2413075

Strand: Reverse

Name: oprN6 [H]

Synonym: XCV2106

Alternate gene names: 78047662

Gene position: 2413075-2411591 (Counterclockwise)

Preceding gene: 78047663

Following gene: 78047661

Centisome position: 46.6

GC content: 69.56

Gene sequence:

>1485_bases
ATGACCGACGTTCGCAACGCATTGCTCGCCGGTGCCGTGGCGGTATCGCTCGCCGCCTGCGCAGTGGGACCGGACTTTCA
GCGCCCCGCTCTACCTGCTGCCGATCGCTATACCGCCAATGCGTTACCGGCAACGATCGTGGACGCCGACGCGGCGCATG
GTGGTGCGCAGCAGTTCGAGCCCGGGCAGGACGTGCCGGCCGCCTGGTGGCGCGCCTTCGGCTCGCCGCAACTCAATGCT
GTGGTGGAGCGGGCCTTACGTGCCAATCCGGACCTGCAGGCCGCCGACGCAGCGCTCCGGCAGGCGCAGCAGACGCTGGC
CGCACAACGCGGTGCCTGGCTACCGCAAGCGGATCTGCATGTGGATGCCAGCCGGCAACGCGATTCGGTGGTGCCGGCGC
CAGATGCCGGCATCGACACACCGTATGCGCTACGCACCGCCCAACTCAGCGTCAGCTACACGCTGGACGTCTTTGGCGGT
ACGCGGCGGCAAGTGGAAGCGGCCGGTGCGCAAGCACAGGCCCAGCGCGATCAGCGCGATGCGGCGTACCTGAGCCTCAC
CGCCAACGTGGTGAACGCGGCCATTGGCGAGGCGGCCGTGCGCGCGCAACTGGAGGCTGCGCGCGCGCAGGTCGCCATCG
CCGAGCAGCTCTGCACGCTCACCGAACGCCAGCAGGCGCTTGGCGCGCTCGGTGCAGCGCAGGTGCTGGCCCAACGCACT
GCGCTGGCACAGGCACAGGCCGCGGTGCCGGGGCTGGAAAAACAGCTGGAACAGCAACGGACCCTGCTCGCGATTCTGGG
CGGGCAGTTGCCTGGCGACGCTGCGGGTGCGCCGTTTACGCTGGACACGCTGCAATTACCGGCGCAATTGCCGTTATCGC
TGCCCTCGCGGTTGGTCGATCGCCGCCCGGACATCCGCGCCGCCGAAGCGCAGGCGCATGCTGCCAGCGCATTGATCGGC
GTGGCGGCCGCTGCGCGCTTGCCATCCATTACCTTGAGTGCGGCCGGCGGCGGCTCTGCTTCCAGTGTCGGGCGCATGTT
CGCGGCCGGCAATACACAATGGTCGGTGGCCGGCAGCCTGCTGCAACCGCTGTTCCATGGCGGCGCGCTTGCGCATCAGC
AACGGGCGGCCGAAGCTGGCTACGCGCAGGCCATGGCGCAATACCGCAGCGTGGTGCTGAACGCATTTGGCGAGGTTTCC
AACGCGCTCACCGCGCTGCAGAGCGACGCGCAGAACCTGCGCGCCTGTGCCGATGCGCAGGCCCTTGCGGAGCGCACGCT
GGCGCTGGTGCAACGTCAACAGGCGGTCGGTGCGGTGGGCATGGCAGATCTGCTGCAGGCGCAGCAGGCCTACCAAAGCA
CGCAGGCCGCCACGGTCCAGGCACAAGCCGCCCGCTACACCGACACCGTGGCGCTGTATCAGGCCCTGGGTGGCGGGCCG
TGGTGGTCGCCAGCGGCCCAGACGCCCAAGCCCGCGGCTCCATGA

Upstream 100 bases:

>100_bases
TGGTCACCGCCACGGTGCTCACCTTGGTGTTGTTGCCATCGCTTTACTACCTGATGGAAGCCTTCGTCGCAACGCGCCAG
GGCCGCCCGGAGACGACCGC

Downstream 100 bases:

>100_bases
ATCACGCACCGCAGCCAGCGCCGGTTGTGTAACGGCGGCGCCGCCAGCTGAGACAATCGCCGCCATGCGCATGACCTCTC
TCTTCCGCTCGCCACCCACG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MTDVRNALLAGAVAVSLAACAVGPDFQRPALPAADRYTANALPATIVDADAAHGGAQQFEPGQDVPAAWWRAFGSPQLNA
VVERALRANPDLQAADAALRQAQQTLAAQRGAWLPQADLHVDASRQRDSVVPAPDAGIDTPYALRTAQLSVSYTLDVFGG
TRRQVEAAGAQAQAQRDQRDAAYLSLTANVVNAAIGEAAVRAQLEAARAQVAIAEQLCTLTERQQALGALGAAQVLAQRT
ALAQAQAAVPGLEKQLEQQRTLLAILGGQLPGDAAGAPFTLDTLQLPAQLPLSLPSRLVDRRPDIRAAEAQAHAASALIG
VAAAARLPSITLSAAGGGSASSVGRMFAAGNTQWSVAGSLLQPLFHGGALAHQQRAAEAGYAQAMAQYRSVVLNAFGEVS
NALTALQSDAQNLRACADAQALAERTLALVQRQQAVGAVGMADLLQAQQAYQSTQAATVQAQAARYTDTVALYQALGGGP
WWSPAAQTPKPAAP

Sequences:

>Translated_494_residues
MTDVRNALLAGAVAVSLAACAVGPDFQRPALPAADRYTANALPATIVDADAAHGGAQQFEPGQDVPAAWWRAFGSPQLNA
VVERALRANPDLQAADAALRQAQQTLAAQRGAWLPQADLHVDASRQRDSVVPAPDAGIDTPYALRTAQLSVSYTLDVFGG
TRRQVEAAGAQAQAQRDQRDAAYLSLTANVVNAAIGEAAVRAQLEAARAQVAIAEQLCTLTERQQALGALGAAQVLAQRT
ALAQAQAAVPGLEKQLEQQRTLLAILGGQLPGDAAGAPFTLDTLQLPAQLPLSLPSRLVDRRPDIRAAEAQAHAASALIG
VAAAARLPSITLSAAGGGSASSVGRMFAAGNTQWSVAGSLLQPLFHGGALAHQQRAAEAGYAQAMAQYRSVVLNAFGEVS
NALTALQSDAQNLRACADAQALAERTLALVQRQQAVGAVGMADLLQAQQAYQSTQAATVQAQAARYTDTVALYQALGGGP
WWSPAAQTPKPAAP
>Mature_493_residues
TDVRNALLAGAVAVSLAACAVGPDFQRPALPAADRYTANALPATIVDADAAHGGAQQFEPGQDVPAAWWRAFGSPQLNAV
VERALRANPDLQAADAALRQAQQTLAAQRGAWLPQADLHVDASRQRDSVVPAPDAGIDTPYALRTAQLSVSYTLDVFGGT
RRQVEAAGAQAQAQRDQRDAAYLSLTANVVNAAIGEAAVRAQLEAARAQVAIAEQLCTLTERQQALGALGAAQVLAQRTA
LAQAQAAVPGLEKQLEQQRTLLAILGGQLPGDAAGAPFTLDTLQLPAQLPLSLPSRLVDRRPDIRAAEAQAHAASALIGV
AAAARLPSITLSAAGGGSASSVGRMFAAGNTQWSVAGSLLQPLFHGGALAHQQRAAEAGYAQAMAQYRSVVLNAFGEVSN
ALTALQSDAQNLRACADAQALAERTLALVQRQQAVGAVGMADLLQAQQAYQSTQAATVQAQAARYTDTVALYQALGGGPW
WSPAAQTPKPAAP

Specific function: The outer membrane component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin, chloramphenicol, erythromycin, novobiocin, streptomycin and tetracycline. Is not involved in organic solven

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=476, Percent_Identity=26.4705882352941, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI2367348, Length=441, Percent_Identity=26.0770975056689, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50951; Mature: 50819

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVRNALLAGAVAVSLAACAVGPDFQRPALPAADRYTANALPATIVDADAAHGGAQQFE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCC
PGQDVPAAWWRAFGSPQLNAVVERALRANPDLQAADAALRQAQQTLAAQRGAWLPQADLH
CCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VDASRQRDSVVPAPDAGIDTPYALRTAQLSVSYTLDVFGGTRRQVEAAGAQAQAQRDQRD
CCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEEEEEEECCCCHHHHHHHCHHHHHHHHHHH
AAYLSLTANVVNAAIGEAAVRAQLEAARAQVAIAEQLCTLTERQQALGALGAAQVLAQRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQAQAAVPGLEKQLEQQRTLLAILGGQLPGDAAGAPFTLDTLQLPAQLPLSLPSRLVD
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCCCCCCCHHHHHH
RRPDIRAAEAQAHAASALIGVAAAARLPSITLSAAGGGSASSVGRMFAAGNTQWSVAGSL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHH
LQPLFHGGALAHQQRAAEAGYAQAMAQYRSVVLNAFGEVSNALTALQSDAQNLRACADAQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAERTLALVQRQQAVGAVGMADLLQAQQAYQSTQAATVQAQAARYTDTVALYQALGGGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WWSPAAQTPKPAAP
CCCCCCCCCCCCCC
>Mature Secondary Structure 
TDVRNALLAGAVAVSLAACAVGPDFQRPALPAADRYTANALPATIVDADAAHGGAQQFE
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCC
PGQDVPAAWWRAFGSPQLNAVVERALRANPDLQAADAALRQAQQTLAAQRGAWLPQADLH
CCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VDASRQRDSVVPAPDAGIDTPYALRTAQLSVSYTLDVFGGTRRQVEAAGAQAQAQRDQRD
CCCCCCCCCCCCCCCCCCCCCHHEEEEEEEEEEEEEECCCCHHHHHHHCHHHHHHHHHHH
AAYLSLTANVVNAAIGEAAVRAQLEAARAQVAIAEQLCTLTERQQALGALGAAQVLAQRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQAQAAVPGLEKQLEQQRTLLAILGGQLPGDAAGAPFTLDTLQLPAQLPLSLPSRLVD
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCCCCCCCHHHHHH
RRPDIRAAEAQAHAASALIGVAAAARLPSITLSAAGGGSASSVGRMFAAGNTQWSVAGSL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHH
LQPLFHGGALAHQQRAAEAGYAQAMAQYRSVVLNAFGEVSNALTALQSDAQNLRACADAQ
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAERTLALVQRQQAVGAVGMADLLQAQQAYQSTQAATVQAQAARYTDTVALYQALGGGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WWSPAAQTPKPAAP
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]