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The map label for this gene is cysG [H]

Identifier: 78047645

GI number: 78047645

Start: 2381100

End: 2382077

Strand: Reverse

Name: cysG [H]

Synonym: XCV2089

Alternate gene names: 78047645

Gene position: 2382077-2381100 (Counterclockwise)

Preceding gene: 78047658

Following gene: 78047644

Centisome position: 46.0

GC content: 69.73

Gene sequence:

>978_bases
ATGCCGTTGTTCCCGTTGTTCGCCAACCTGCAGGGGCGCGCTGTGCTGGTGATCGGTGGCGGCGAAGTCGCTACACGCAA
GGTGCTGGCGCTGCTGAAGGCGCAGGCGCACATCCGGCTGTATGCGCATGCGCTTTCGCCCGAACTTGCCCAGTTGATGC
AGGCCGGGCGCTTTGAGCAAATGACAGGCGAGTTCGATCCTGCCTGGATCGACACCGTGTGGCTGGTCGTCGCCGCCACC
GATGATGTGGATCTGAATCAACGTGTGGCCGCAGCGGCCGGCGCACGCCAGCGTCTGGTCAATGTCGTGGACGATGCCGA
GCTCTCCACCTACCAGGTGCCGGCCATTGTCGACCGCGATCCGCTGGTGATTGCGATTTCGTCGGCGGGCGCGGCGCCGA
TGCTGGCGCGCCGACTGCGCGAGCGACTGGAGCGCGAACTGCATGCGTCGGTGGGTACGCTGGCGGCCTTGTTCGCCCGG
CACCGCGAGCGCATTCGTCAGCAGTTGCCGGACATGAACCGGCGGCGCCGCTGGTTCGACCAGGTGATCGACGGGAAGGT
GCCGCAATTGCTGCAGGCCGGCGATACCGTCGCCGCCGAAGCCGCCTTTGCCGCTGCGTTGGACGCGGTGGACAGCGTTC
CGGCGCGCGGCAGCGTGCAATGGGTCGGTGCCGGCCCGGGCGATCCCGGCCTGCTCACGCTCAATGCCTTGCGTGCCCTG
AACCTGGCCGACGTGCTGCTGCTGGCGTCGGACGTGCCCGCCGCGGTGGTGGAACTGGCGCGCCGGGACGCGCAACGGCG
CGCCTGGCCGGAGACGCCGGGCGCGCAGCAGGCCGCCGTAGTGGAGTTGGTCGGCGCCGGGCTGCAGGTCGTGGTCCTGC
GCATGGGCAGCGGCGATGCCATCCCGGCGGAGCTGGACGCCGCGCTGCACGCGCAGGGCATCCTGTCGGTGCGGGTTCCG
GGTTTGCCGCTCCGCTAG

Upstream 100 bases:

>100_bases
TTGACCAGCAAAACACGCATTGACAGCAGCGAGGCATGGACGTGGCCTGATGGTGCCATGCAACATGCCGCTCGTGCGAG
CCATCTTTTCGGAGTGTCCG

Downstream 100 bases:

>100_bases
ATTTTTCCAAGCGCGTTGCCGGATTCGACGCGCCTGAACGCGACTGCCTACCGCGCCAGCAACGCTCGGCGCGCCGTGTC
CTGCTGCCAACGCGTGCGTT

Product: putative siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MPLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLMQAGRFEQMTGEFDPAWIDTVWLVVAAT
DDVDLNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRDPLVIAISSAGAAPMLARRLRERLERELHASVGTLAALFAR
HRERIRQQLPDMNRRRRWFDQVIDGKVPQLLQAGDTVAAEAAFAAALDAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
NLADVLLLASDVPAAVVELARRDAQRRAWPETPGAQQAAVVELVGAGLQVVVLRMGSGDAIPAELDAALHAQGILSVRVP
GLPLR

Sequences:

>Translated_325_residues
MPLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLMQAGRFEQMTGEFDPAWIDTVWLVVAAT
DDVDLNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRDPLVIAISSAGAAPMLARRLRERLERELHASVGTLAALFAR
HRERIRQQLPDMNRRRRWFDQVIDGKVPQLLQAGDTVAAEAAFAAALDAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
NLADVLLLASDVPAAVVELARRDAQRRAWPETPGAQQAAVVELVGAGLQVVVLRMGSGDAIPAELDAALHAQGILSVRVP
GLPLR
>Mature_324_residues
PLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLMQAGRFEQMTGEFDPAWIDTVWLVVAATD
DVDLNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRDPLVIAISSAGAAPMLARRLRERLERELHASVGTLAALFARH
RERIRQQLPDMNRRRRWFDQVIDGKVPQLLQAGDTVAAEAAFAAALDAVDSVPARGSVQWVGAGPGDPGLLTLNALRALN
LADVLLLASDVPAAVVELARRDAQRRAWPETPGAQQAAVVELVGAGLQVVVLRMGSGDAIPAELDAALHAQGILSVRVPG
LPLR

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=267, Percent_Identity=40.0749063670412, Blast_Score=185, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 34737; Mature: 34605

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLMQAGRFEQ
CCCCCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
MTGEFDPAWIDTVWLVVAATDDVDLNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRD
HCCCCCCHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEECCC
PLVIAISSAGAAPMLARRLRERLERELHASVGTLAALFARHRERIRQQLPDMNRRRRWFD
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QVIDGKVPQLLQAGDTVAAEAAFAAALDAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
HHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEHHHHHHH
NLADVLLLASDVPAAVVELARRDAQRRAWPETPGAQQAAVVELVGAGLQVVVLRMGSGDA
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCC
IPAELDAALHAQGILSVRVPGLPLR
CCHHHHHHHHHCCEEEEECCCCCCC
>Mature Secondary Structure 
PLFPLFANLQGRAVLVIGGGEVATRKVLALLKAQAHIRLYAHALSPELAQLMQAGRFEQ
CCCCCHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHH
MTGEFDPAWIDTVWLVVAATDDVDLNQRVAAAAGARQRLVNVVDDAELSTYQVPAIVDRD
HCCCCCCHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEECCC
PLVIAISSAGAAPMLARRLRERLERELHASVGTLAALFARHRERIRQQLPDMNRRRRWFD
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QVIDGKVPQLLQAGDTVAAEAAFAAALDAVDSVPARGSVQWVGAGPGDPGLLTLNALRAL
HHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEHHHHHHH
NLADVLLLASDVPAAVVELARRDAQRRAWPETPGAQQAAVVELVGAGLQVVVLRMGSGDA
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEEEEEEEECCCCC
IPAELDAALHAQGILSVRVPGLPLR
CCHHHHHHHHHCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]