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The map label for this gene is lvr [H]

Identifier: 78047643

GI number: 78047643

Start: 2378392

End: 2379324

Strand: Reverse

Name: lvr [H]

Synonym: XCV2087

Alternate gene names: 78047643

Gene position: 2379324-2378392 (Counterclockwise)

Preceding gene: 78047644

Following gene: 78047638

Centisome position: 45.95

GC content: 69.02

Gene sequence:

>933_bases
ATGGCTAAGCCGCAGGATCTGCGCGGCTGGAATGCGGTGATCACCGGCGGCGCCGGCGGGCTGGGACGCGCGATCGCCGC
GCGCCTGATCCAGCGCGGCGTGCGCTGTCTGCTGGTGGATATCGATGCCGATGCACTGGCACGTGCGGTGCAGGCGCTGG
GGCCGCTGGCGTGCGCGCAGGTGGCCGACCTGACCGACCCGGCCGCGCGCGACCGTCTCGCCGAGCGGCTCGACACGGAT
TGGGGCCAGTTGCAGCTGTTGGTCAACAACGCCGGCATCGTCGGCACCACTCCGTTCGAGCAGCGCACGCCGGCGTCGAT
CCGCGGCGAACTGGAGTTGAACCTGATGGCGCCGTTGTTGCTCACGCACCGGTTGCTGCCGCTGCTGCAGCGCAGTGGCG
ACGGGCGCGTGGTGAACATCGTCTCGCTGGGCGGCATGTTCCCGTTGCCGGAATCGACGGTCTACTCGGCCAGCAAGTTC
GGGCTGCGCGGTGCCATGCTCTGCCTGGGACTGGACGGCGCACGCCTGGGCATTCGCGTCTCCATCGTCAACCCGTCGGC
CACCGACACCCCGATGCTGATGCGCGAGGCCCTCAACGGCGGCAACAAGTTGCAGTTCATGGATCGGCCGCAACAACCGG
ACGAAGTCGCATTGCAGGTGTTGCGGTGCCTGGACGCACCGTGCCTGGAGCGCTTCGTGCGCCCCAGCGAATCGTGGACG
GTGCGGCTGGCCATGCTGCTGCCCAACCTGCTGACGCGCGCCCTGCCGCTGTTCGCACGCAGCGCCGAGCGTGGGCATCG
CAACTATCTTGCGTCGCTGCAGCAGCGTGGCCTGATTCGCCCGCGCCAGGACGGATGGGAAGTGGTGCCGCCCGCTCACC
GCGAAGACCCGCACACCCTTGCTGCAACGCGAGCAACCACGCAGCGGACCTGA

Upstream 100 bases:

>100_bases
CTGGGCGAACACATGTACGACGCGCTCAAGCTCGACGCCGGTGGCGATCCACGCATGGGCACTACCGCCACCGCACGGCT
GGCCGACAGCGAGGTTGCCC

Downstream 100 bases:

>100_bases
GCCGCTGCCTGGCGCCCGCACGCTCAGCGCATGCGGCGGCAGCGCTGTTGGAGGGCAAACCGGTGCGCCGCTAAGGCCAA
GTACCGTGTCTGGTCGAACC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MAKPQDLRGWNAVITGGAGGLGRAIAARLIQRGVRCLLVDIDADALARAVQALGPLACAQVADLTDPAARDRLAERLDTD
WGQLQLLVNNAGIVGTTPFEQRTPASIRGELELNLMAPLLLTHRLLPLLQRSGDGRVVNIVSLGGMFPLPESTVYSASKF
GLRGAMLCLGLDGARLGIRVSIVNPSATDTPMLMREALNGGNKLQFMDRPQQPDEVALQVLRCLDAPCLERFVRPSESWT
VRLAMLLPNLLTRALPLFARSAERGHRNYLASLQQRGLIRPRQDGWEVVPPAHREDPHTLAATRATTQRT

Sequences:

>Translated_310_residues
MAKPQDLRGWNAVITGGAGGLGRAIAARLIQRGVRCLLVDIDADALARAVQALGPLACAQVADLTDPAARDRLAERLDTD
WGQLQLLVNNAGIVGTTPFEQRTPASIRGELELNLMAPLLLTHRLLPLLQRSGDGRVVNIVSLGGMFPLPESTVYSASKF
GLRGAMLCLGLDGARLGIRVSIVNPSATDTPMLMREALNGGNKLQFMDRPQQPDEVALQVLRCLDAPCLERFVRPSESWT
VRLAMLLPNLLTRALPLFARSAERGHRNYLASLQQRGLIRPRQDGWEVVPPAHREDPHTLAATRATTQRT
>Mature_309_residues
AKPQDLRGWNAVITGGAGGLGRAIAARLIQRGVRCLLVDIDADALARAVQALGPLACAQVADLTDPAARDRLAERLDTDW
GQLQLLVNNAGIVGTTPFEQRTPASIRGELELNLMAPLLLTHRLLPLLQRSGDGRVVNIVSLGGMFPLPESTVYSASKFG
LRGAMLCLGLDGARLGIRVSIVNPSATDTPMLMREALNGGNKLQFMDRPQQPDEVALQVLRCLDAPCLERFVRPSESWTV
RLAMLLPNLLTRALPLFARSAERGHRNYLASLQQRGLIRPRQDGWEVVPPAHREDPHTLAATRATTQRT

Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=228, Percent_Identity=28.0701754385965, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4503817, Length=231, Percent_Identity=24.2424242424242, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI142976729, Length=250, Percent_Identity=24, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI31542939, Length=221, Percent_Identity=28.5067873303167, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI40254992, Length=223, Percent_Identity=28.2511210762332, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI50726952, Length=195, Percent_Identity=35.8974358974359, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI223718074, Length=248, Percent_Identity=27.8225806451613, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=30.5882352941176, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082100, Length=221, Percent_Identity=28.0542986425339, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787335, Length=187, Percent_Identity=27.807486631016, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787905, Length=140, Percent_Identity=32.8571428571429, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786812, Length=187, Percent_Identity=27.807486631016, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790717, Length=189, Percent_Identity=29.1005291005291, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787820, Length=175, Percent_Identity=28, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1789057, Length=189, Percent_Identity=30.1587301587302, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788459, Length=190, Percent_Identity=29.4736842105263, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786701, Length=177, Percent_Identity=29.3785310734463, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=202, Percent_Identity=25.2475247524752, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=194, Percent_Identity=29.3814432989691, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=24.6153846153846, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=28.6458333333333, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=209, Percent_Identity=30.1435406698565, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17570069, Length=179, Percent_Identity=31.8435754189944, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=187, Percent_Identity=31.0160427807487, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=197, Percent_Identity=27.9187817258883, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=187, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=230, Percent_Identity=27.3913043478261, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=190, Percent_Identity=28.4210526315789, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=187, Percent_Identity=26.7379679144385, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=189, Percent_Identity=25.9259259259259, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21355631, Length=168, Percent_Identity=30.952380952381, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281364892, Length=263, Percent_Identity=26.9961977186312, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=30.0518134715026, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24644339, Length=210, Percent_Identity=27.1428571428571, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21356301, Length=202, Percent_Identity=25.2475247524752, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640492, Length=192, Percent_Identity=25.5208333333333, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI23397609, Length=194, Percent_Identity=31.9587628865979, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21358495, Length=235, Percent_Identity=25.9574468085106, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24665243, Length=228, Percent_Identity=30.2631578947368, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331218, Length=228, Percent_Identity=30.2631578947368, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581726, Length=198, Percent_Identity=28.7878787878788, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357041, Length=218, Percent_Identity=26.605504587156, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 33728; Mature: 33596

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPQDLRGWNAVITGGAGGLGRAIAARLIQRGVRCLLVDIDADALARAVQALGPLACAQ
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCHHHHHH
VADLTDPAARDRLAERLDTDWGQLQLLVNNAGIVGTTPFEQRTPASIRGELELNLMAPLL
HHHCCCHHHHHHHHHHHCCCCHHEEEEEECCCEEECCCCCCCCCCCCCCEEEEHHHHHHH
LTHRLLPLLQRSGDGRVVNIVSLGGMFPLPESTVYSASKFGLRGAMLCLGLDGARLGIRV
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEE
SIVNPSATDTPMLMREALNGGNKLQFMDRPQQPDEVALQVLRCLDAPCLERFVRPSESWT
EEECCCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCE
VRLAMLLPNLLTRALPLFARSAERGHRNYLASLQQRGLIRPRQDGWEVVPPAHREDPHTL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
AATRATTQRT
HHHCHHCCCC
>Mature Secondary Structure 
AKPQDLRGWNAVITGGAGGLGRAIAARLIQRGVRCLLVDIDADALARAVQALGPLACAQ
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCHHHHHH
VADLTDPAARDRLAERLDTDWGQLQLLVNNAGIVGTTPFEQRTPASIRGELELNLMAPLL
HHHCCCHHHHHHHHHHHCCCCHHEEEEEECCCEEECCCCCCCCCCCCCCEEEEHHHHHHH
LTHRLLPLLQRSGDGRVVNIVSLGGMFPLPESTVYSASKFGLRGAMLCLGLDGARLGIRV
HHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEE
SIVNPSATDTPMLMREALNGGNKLQFMDRPQQPDEVALQVLRCLDAPCLERFVRPSESWT
EEECCCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCE
VRLAMLLPNLLTRALPLFARSAERGHRNYLASLQQRGLIRPRQDGWEVVPPAHREDPHTL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
AATRATTQRT
HHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11388460; 10508066 [H]